Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development.

Autor: Carlson DL; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA., Kowalewski M; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, 120 Mason Farm Road, 3(rd) Floor, Genetic Medicine Building, Chapel Hill, NC 27599, USA., Bodoor K; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA., Lietzan AD; Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, The University of North Carolina at Chapel Hill, 385 South Columbia Street, Chapel Hill, NC 27599, USA., Hughes PF; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA., Gooden D; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA., Loiselle DR; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA., Alcorta D; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA., Dingman Z; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA., Mueller EA; Sarafan ChEM-H Institute, Stanford University, 290 Jane Stanford Way, Stanford, CA 94035, USA., Irnov I; Sarafan ChEM-H Institute, Stanford University, 290 Jane Stanford Way, Stanford, CA 94035, USA., Modla S; Delaware Biotechnology Institute, University of Delaware, 590 Avenue 1743, Newark, DE 19713, USA., Chaya T; Delaware Biotechnology Institute, University of Delaware, 590 Avenue 1743, Newark, DE 19713, USA., Caplan J; Delaware Biotechnology Institute, University of Delaware, 590 Avenue 1743, Newark, DE 19713, USA., Embers M; Department of Microbiology and Immunology, 18703 Three Rivers Road, Covington, LA 70433, USA., Miller JC; Galaxy Diagnostics, Inc, P.O. Box 14346 7020 Kit Creek Road, Ste 130, Research Triangle Park, Raliegh, NC 27709, USA., Jacobs-Wagner C; Sarafan ChEM-H Institute, Stanford University, 290 Jane Stanford Way, Stanford, CA 94035, USA; Biology Department, Stanford University, 290 Jane Stanford Way, Stanford, CA 94035, USA; Howard Hughes Medical Institute, Stanford University, 290 Jane Stanford Way, Stanford, CA 94035, USA., Redinbo MR; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, 120 Mason Farm Road, 3(rd) Floor, Genetic Medicine Building, Chapel Hill, NC 27599, USA; Department of Chemistry, University of North Carolina at Chapel Hill, 4350 Genome Sciences Building, 250 Bell Tower Drive, Chapel Hill, NC 27599-3290, USA. Electronic address: redinbo@unc.edu., Spector N; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA., Haystead TAJ; Department of Pharmacology and Cancer Biology, Duke University, C119 LSRC, Research Drive, Durham NC 27701, USA. Electronic address: timothy.haystead@duke.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2024 Mar 21; Vol. 31 (3), pp. 465-476.e12. Date of Electronic Publication: 2023 Nov 01.

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An Exploratory Study on the Microbiome of Northern and Southern Populations of Ixodes scapularis Ticks Predicts Changes and Unique Bacterial Interactions.

Autor: Kumar D; School of Biological, Environmental and Earth Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA., Downs LP; School of Biological, Environmental and Earth Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA., Adegoke A; School of Biological, Environmental and Earth Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA., Machtinger E; Department of Entomology, Pennsylvania State University, University Park, PA 16802, USA., Oggenfuss K; Cary Institute of Ecosystem Studies, Millbrook, NY 12542, USA., Ostfeld RS; Cary Institute of Ecosystem Studies, Millbrook, NY 12542, USA., Embers M; Division of Immunology, Tulane National Primate Research Center, 18703 Three Rivers Rd., Covington, LA 70433, USA., Karim S; School of Biological, Environmental and Earth Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA.; Center for Molecular and Cellular Biosciences, University of Southern Mississippi, Hattiesburg, MS 39406, USA.

Publikováno v: Pathogens (Basel, Switzerland) [Pathogens] 2022 Jan 21; Vol. 11 (2). Date of Electronic Publication: 2022 Jan 21.

Bridging the gap: Insights in the immunopathology of Lyme borreliosis.

Autor: Snik ME; Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Stouthamer NEIM; Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Hovius JW; Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands.; Division of Infectious Diseases, Department of Internal Medicine, Amsterdam UMC Multidisciplinary Lyme borreliosis Center, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., van Gool MMJ; Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands.

Publikováno v: European journal of immunology [Eur J Immunol] 2024 Oct 13, pp. e2451063. Date of Electronic Publication: 2024 Oct 13.

Stationary phase persister/biofilm microcolony of Borrelia burgdorferi causes more severe disease in a mouse model of Lyme arthritis: implications for understanding persistence, Post-treatment Lyme Disease Syndrome (PTLDS), and treatment failure.

Autor: Feng J; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.; Institute of Pathogen Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000, China., Li T; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.; Institute of Pathogen Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000, China., Yee R; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA., Yuan Y; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA., Bai C; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA., Cai M; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA., Shi W; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA., Embers M; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA., Brayton C; Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Saeki H; Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Gabrielson K; Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Zhang Y; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.; Corresponding author: yzhang@jhsph.edu.

Publikováno v: Discovery medicine [Discov Med] 2019 Mar; Vol. 27 (148), pp. 125-138.