Metformin Hydrochloride-Loaded PLGA Nanoparticle in Periodontal Disease Experimental Model Using Diabetic Rats

Autor: Aline de Sousa Barbosa Freitas Pereira, Gerly Anne de Castro Brito, Maria Laura de Souza Lima, Arnóbio Antônio da Silva Júnior, Emanuell dos Santos Silva, Adriana Augusto de Rezende, Raul Hernandes Bortolin, Maria Galvan, Flávia Q. Pirih, Raimundo Fernandes de Araújo Júnior, Caroline Addison Carvalho Xavier de Medeiros, Gerlane Coelho Bernando Guerra, Aurigena Antunes de Araújo

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 11, p 3488 (2018)

Evidence shows that metformin is an antidiabetic drug, which can exert favorable anti-inflammatory effects and decreased bone loss. The development of nanoparticles for metformin might be useful for increased therapeutic efficacy. The aim of this stu

Externí odkaz: https://doaj.org/article/3026fb709ea140f8bdadde2fa0b7857b

In vitro-in vivo availability of metformin hydrochloride-PLGA nanoparticles in diabetic rats in a periodontal disease experimental model

Autor: Emily Cintia Tossi de Araújo Costa, Artur de Santana Oliveira, Aline de Sousa Barbosa Freitas Pereira, Emanuell Dos Santos Silva, Gerly Anne de Castro Brito, Caroline Addison Carvalho Xavier de Medeiros, Aurigena Antunes de Araújo, Jovelina Samara Ferreira Alves, Raimundo Fernandes de Araújo Júnior, Agnes Andrade Martins, Maria Laura de Souza Lima, Gerlane Coelho Bernardo Guerra, Arnóbio Antônio da Silva-Júnior, Renata Ferreira de Carvalho Leitão, Leandro de Santis Ferreira

Publikováno v: Pharmaceutical Biology, Vol 59, Iss 1, Pp 1576-1584 (2021)
Pharmaceutical Biology
article-version (VoR) Version of Record

Context Metformin is an important oral anti-hyperglycemic used in diabetes. Polylactic-co-glycolic acid (PLGA) has been widely used due to its reliability in controlling the release of drugs. Objective This study evaluates the in vitro-in vivo availa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584cd6364aedba491793ea3e1c57a105
https://doaj.org/article/7d4d72e176694e5aa3a792b23b8a3c96

Colloidal properties of self-assembled cationic hyperbranched-polyethyleneimine covered poly lactide-co-glycolide nanoparticles: Exploring modified release and cell delivery of methotrexate

Autor: Emanuell dos-Santos-Silva, Eryvaldo Sócrates Tabosa do Egito, Juliana S. de Medeiros, Rômulo dos Santos-Cavalcante, Matheus F. Fernandes-Pedrosa, Mariana Farias Alves-Silva, Arnóbio Antônio da Silva-Júnior, Alianda Maira Cornélio, Raimundo F. de Araújo-Júnior

Publikováno v: Journal of Molecular Liquids. 315:113721

This study explores the hypothesis that the colloidal properties of nanocarriers can modulate the interaction of hydrophilic and anionic chemotherapy agents with biological surfaces, especially tumoral cells. Different compositions were tested for pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a1f8821589daf285a2c83fe3111e9f7
https://doi.org/10.1016/j.molliq.2020.113721

Biodegradable cross-linked chitosan nanoparticles improve anti-Candida and anti-biofilm activity of TistH, a peptide identified in the venom gland of the Tityus stigmurus scorpion

Autor: Matheus F. Fernandes-Pedrosa, Luanda Bárbara Ferreira Canário de Souza, Fiamma Gláucia-Silva, Karla Samara Rocha Soares, Arnóbio Antônio da Silva-Júnior, Emanuell dos Santos-Silva, Ariane F. Lacerda, Manoela Torres-Rêgo, Guilherme Maranhão Chaves, Igor Zumba Damasceno

Publikováno v: Materials Science and Engineering: C. 103:109830

Among several bioactive peptides identified from the venom glands of the Tityus stigmurus scorpion, one peptide with hypotensive action (TistH, Tityus stigmurus Hypotensin) showed multifunctional and biotechnological applications. The maximum efficac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dca240ad58e9e1ee51a734c49d84dde
https://doi.org/10.1016/j.msec.2019.109830

Metformin Hydrochloride-Loaded PLGA Nanoparticle in Periodontal Disease Experimental Model Using Diabetic Rats

Autor: Aurigena Antunes de Araújo, Gerlane Coelho Bernando Guerra, Maria Galvan, Gerly Anne de Castro Brito, Flavia Q. Pirih, Maria Laura de Souza Lima, Caroline Addison Carvalho Xavier de Medeiros, Emanuell Dos Santos Silva, Arnóbio Antônio da Silva Júnior, Aline de Sousa Barbosa Freitas Pereira, Raul Hernandes Bortolin, Adriana Augusto de Rezende, Raimundo Fernandes de Araújo Júnior

Publikováno v: International journal of molecular sciences, vol 19, iss 11
International Journal of Molecular Sciences
Volume 19
Issue 11
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3488 (2018)

Evidence shows that metformin is an antidiabetic drug, which can exert favorable anti-inflammatory effects and decreased bone loss. The development of nanoparticles for metformin might be useful for increased therapeutic efficacy. The aim of this stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df776ac77fb3708f222c0bf9053253b6
https://doi.org/10.3390/ijms19113488