Zobrazeno 1 - 10
of 262
pro vyhledávání: '"Emanuele di Angelantonio"'
Autor:
Matthew Sperrin, Angela M Wood, Lois Kim, Zhe Xu, Emanuele Di Angelantonio, Stephen Kaptoge, Juliet Usher-Smith, Matthew Arnold, Linda Gough, Lisa Pennells, Ryan Chung
Publikováno v:
BMJ Medicine, Vol 3, Iss 1 (2024)
Objective To quantify the potential advantages of using 10 year risk prediction models for cardiovascular disease, in combination with risk thresholds specific to both age and sex, to identify individuals at high risk of cardiovascular disease for al
Externí odkaz:
https://doaj.org/article/a80dc0ed55f64483a5af4a34cd24ba29
Autor:
Jun Yu Chen, Maddalena Ardissino, Rohin K. Reddy, Amy Marie Mason, Zahra Raisi‐Estabragh, Emanuele Di Angelantonio, Stephen Burgess, Fu Siong Ng
Publikováno v:
ESC Heart Failure, Vol 10, Iss 6, Pp 3525-3537 (2023)
Abstract Aims Observational evidence suggests associations between sex hormone levels and heart failure (HF). We used sex‐specific genetic variants associated with androgenic sex hormone profiles to investigate the causal relevance of androgenic se
Externí odkaz:
https://doaj.org/article/a8c1ad0d943f44e29eb98a5077604b88
Autor:
Parsa Akbari, Dragana Vuckovic, Luca Stefanucci, Tao Jiang, Kousik Kundu, Roman Kreuzhuber, Erik L. Bao, Janine H. Collins, Kate Downes, Luigi Grassi, Jose A. Guerrero, Stephen Kaptoge, Julian C. Knight, Stuart Meacham, Jennifer Sambrook, Denis Seyres, Oliver Stegle, Jeffrey M. Verboon, Klaudia Walter, Nicholas A. Watkins, John Danesh, David J. Roberts, Emanuele Di Angelantonio, Vijay G. Sankaran, Mattia Frontini, Stephen Burgess, Taco Kuijpers, James E. Peters, Adam S. Butterworth, Willem H. Ouwehand, Nicole Soranzo, William J. Astle
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Blood cells contain functionally important intracellular structures, such as granules, critical to immunity and thrombosis. Quantitative variation in these structures has not been subjected previously to large-scale genetic analysis. We perf
Externí odkaz:
https://doaj.org/article/933ad5fb05dc4e368d06635bf8fe0d85
Autor:
Amy McMahon, Stephen Kaptoge, Matthew Walker, Susan Mehenny, Philippe T Gilchrist, Jennifer Sambrook, Naim Akhtar, Michael Sweeting, Angela M Wood, Kathleen Stirrups, Ryan Chung, Sarah Fahle, Elisha Johnson, Donna Cullen, Rosemary Godfrey, Shannon Duthie, Louise Allen, Paul Harvey, Michael Berkson, Elizabeth Allen, Nicholas A Watkins, John R Bradley, Nathalie Kingston, Gail Miflin, Jane Armitage, David J Roberts, John Danesh, Emanuele Di Angelantonio
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Background Vasovagal reactions (VVRs) are the most common acute complications of blood donation. Responsible for substantial morbidity, they also reduce the likelihood of repeated donations and are disruptive and costly for blood services. A
Externí odkaz:
https://doaj.org/article/bef72c0310314c5cb75cc17ac47188af
Autor:
Jeffrey D. Wall, J. Fah Sathirapongsasuti, Ravi Gupta, Asif Rasheed, Radha Venkatesan, Saurabh Belsare, Ramesh Menon, Sameer Phalke, Anuradha Mittal, John Fang, Deepak Tanneeru, Manjari Deshmukh, Akshi Bassi, Jacqueline Robinson, Ruchi Chaudhary, Sakthivel Murugan, Zameer ul-Asar, Imran Saleem, Unzila Ishtiaq, Areej Fatima, Saqib Shafi Sheikh, Shahid Hameed, Mohammad Ishaq, Syed Zahed Rasheed, Fazal-ur-Rehman Memon, Anjum Jalal, Shahid Abbas, Philippe Frossard, Christian Fuchsberger, Lukas Forer, Sebastian Schoenherr, Qixin Bei, Tushar Bhangale, Jennifer Tom, Santosh Gopi Krishna Gadde, Priya B V, Naveen Kumar Naik, Minxian Wang, Pui-Yan Kwok, Amit V. Khera, B. R. Lakshmi, Adam S. Butterworth, Rajiv Chowdhury, John Danesh, Emanuele di Angelantonio, Aliya Naheed, Vinay Goyal, Rukmini M. Kandadai, Hrishikesh Kumar, Rupam Borgohain, Adreesh Mukherjee, Pettarusp M. Wadia, Ravi Yadav, Soaham Desai, Niraj Kumar, Atanu Biswas, Pramod Kumar Pal, Uday B. Muthane, Shymal K. Das, Vedam L. Ramprasad, Prashanth L. Kukkle, Somasekar Seshagiri, Sekar Kathiresan, Arkasubhra Ghosh, V. Mohan, Danish Saleheen, Eric W. Stawiski, Andrew S. Peterson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The benefits of large-scale genetic studies for healthcare of the populations studied are well documented, but these genetic studies have traditionally ignored people from some parts of the world, such as South Asia. Here we describe whole g
Externí odkaz:
https://doaj.org/article/c5c553736d824d84a9c6fd8682dcf4dd
Autor:
Ryan Chung, Zhe Xu, Matthew Arnold, Samantha Ip, Hannah Harrison, Jessica Barrett, Lisa Pennells, Lois G. Kim, Emanuele Di Angelantonio, Ellie Paige, Scott C. Ritchie, Michael Inouye, Juliet A. Usher‐Smith, Angela M. Wood
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 15 (2023)
Background The aim of this study was to provide quantitative evidence of the use of polygenic risk scores for systematically identifying individuals for invitation for full formal cardiovascular disease (CVD) risk assessment. Methods and Results A to
Externí odkaz:
https://doaj.org/article/c219f2af3e6b407891c106228668ab08
Autor:
Scott C. Ritchie, Praveen Surendran, Savita Karthikeyan, Samuel A. Lambert, Thomas Bolton, Lisa Pennells, John Danesh, Emanuele Di Angelantonio, Adam S. Butterworth, Michael Inouye
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-15 (2023)
Abstract Metabolic biomarker data quantified by nuclear magnetic resonance (NMR) spectroscopy in approximately 121,000 UK Biobank participants has recently been released as a community resource, comprising absolute concentrations and ratios of 249 ci
Externí odkaz:
https://doaj.org/article/ed35ebeeea8940d695ceb67db7b808ab
Autor:
Carles Foguet, Yu Xu, Scott C. Ritchie, Samuel A. Lambert, Elodie Persyn, Artika P. Nath, Emma E. Davenport, David J. Roberts, Dirk S. Paul, Emanuele Di Angelantonio, John Danesh, Adam S. Butterworth, Christopher Yau, Michael Inouye
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, the authors present a method to build genetically personalised metabolic models across tissues to estimate individualised reaction fluxes. A fluxome-wide association study in UK Biobank identifies fluxes associated with metabolites and coronary
Externí odkaz:
https://doaj.org/article/23538818abb444f69d502c15c55eb6de
Autor:
Lingyan Chen, James E. Peters, Bram Prins, Elodie Persyn, Matthew Traylor, Praveen Surendran, Savita Karthikeyan, Ekaterina Yonova-Doing, Emanuele Di Angelantonio, David J. Roberts, Nicholas A. Watkins, Willem H. Ouwehand, John Danesh, Cathryn M. Lewis, Paola G. Bronson, Hugh S. Markus, Stephen Burgess, Adam S. Butterworth, Joanna M. M. Howson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Mendelian randomization can be used to mimic the effects of protein-targeting drugs in a population of individuals. Here, the authors have identified potential causal proteins for stroke in a two-sample Mendelian randomization framework, providing po
Externí odkaz:
https://doaj.org/article/36ad3820dd294fba8ce25e16910ffecf
Autor:
Vasiliki Bountziouka, Christopher P. Nelson, Veryan Codd, Qingning Wang, Crispin Musicha, Elias Allara, Stephen Kaptoge, Emanuele Di Angelantonio, Adam S. Butterworth, John R. Thompson, Elizabeth M. Curtis, Angela M. Wood, John N. Danesh, Nicholas C. Harvey, Cyrus Cooper, Nilesh J. Samani
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 3, Pp 1741-1751 (2022)
Abstract Background Frailty is a multidimensional syndrome of decline that affects multiple systems and predisposes to adverse health outcomes. Although chronological age is the major risk factor, inter‐individual variation in risk is not fully und
Externí odkaz:
https://doaj.org/article/7835e4971f7a45b3beda0d40bd4dece1