Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Emanuele Sher"'
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 775 (2023)
Neuropathic pain is a debilitating condition affecting around 8% of the adult population in the UK. The pathophysiology is complex and involves a wide range of processes, including alteration of neuronal excitability and synaptic transmission, dysreg
Externí odkaz:
https://doaj.org/article/24e33f866f574491a9d56709b7718837
Autor:
Anna Chatzidaki, Antoine Fouillet, Jingling Li, Jeffrey Dage, Neil S Millar, Emanuele Sher, Daniel Ursu
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125116 (2015)
Neurons derived from human induced pluripotent stem cells (iPSCs) represent a potentially valuable tool for the characterisation of neuronal receptors and ion channels. Previous studies on iPSC-derived neuronal cells have reported the functional char
Externí odkaz:
https://doaj.org/article/48145ceffbc640209ab8c82d6a69731d
Autor:
Morten Skøtt Thomsen, Ruud Zwart, Daniel Ursu, Majbrit Myrup Jensen, Lars Hageman Pinborg, Gary Gilmour, Jie Wu, Emanuele Sher, Jens Damsgaard Mikkelsen
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130572 (2015)
The existence of α7β2 nicotinic acetylcholine receptors (nAChRs) has recently been demonstrated in both the rodent and human brain. Since α7-containing nAChRs are promising drug targets for schizophrenia and Alzheimer's disease, it is critical to
Externí odkaz:
https://doaj.org/article/2cc02c47cc8244f3991aa4db270c3f4b
Autor:
Cecilia Gotti, Milena Moretti, Iwo Bohr, Iryna Ziabreva, Silvia Vailati, Renato Longhi, Loredana Riganti, Annalisa Gaimarri, Ian G. McKeith, Robert H. Perry, Dag Aarsland, Jan Petter Larsen, Emanuele Sher, Ruth Beattie, Francesco Clementi, Jennifer A. Court
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 2, Pp 481-489 (2006)
Antibodies raised against human α2-6 and β2-4 nicotinic receptor subunits were utilized to fractionate 3H-epibatidine binding in human temporal cortex and striatum. The predominant receptor subtypes in both regions contained α4 and β2 subunits. I
Externí odkaz:
https://doaj.org/article/58d26e8963cd4e5683a49d3e74863539
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55047 (2013)
Subtype-selective ligands are important tools for the pharmacological characterisation of neurotransmitter receptors. This is particularly the case for nicotinic acetylcholine receptors (nAChRs), given the heterogeneity of their subunit composition.
Externí odkaz:
https://doaj.org/article/8283b8096ae04ea595fff848074f10bf
Autor:
Emma R. Dorris, Debra Dulake, Nick Shenker, Amanda C de C Williams, Robert J Moots, Craig Bullock, Zsuzsanna Helyes, David Clauw, Claudia Sommer, Eva Kosek, David Andersson, Andreas Goebel, Richard Dulake, Neil Basu, Rachael Bashford-Rogers, Emanuele Sher, Jennifer M.A. Laird, Hayley McCullough, Ernest Choy, Herta Flor, Gary MacFarlane, Serge Perrot, Chris Barker, Marcia Glanvill, Stuart Bevan, Sarosh R. Irani, Andrew Marshall, Camilla I. Svensson, Geoff Wood
Publikováno v:
Pain medicine (Malden, Mass.). 23(6)
Background Fibromyalgia syndrome (FMS) is the most common chronic widespread pain condition in rheumatology. Until recently, no clear pathophysiological mechanism for fibromyalgia had been established, resulting in management challenges. Recent resea
Autor:
Paul L. Ornstein, David S. Bredt, Vanessa N. Barth, Eric S. Nisenbaum, Kar-Chan Choong, Wenhong Guo, Warren J. Porter, Kevin Matthew Gardinier, Emanuele Sher, Yue-Wei Qian, Jon K. Reel, Christian C. Felder, John T. Catlow, Rosa Maria A. Simmons, Kevin D. Burris, Kelly L. Knopp, Douglas Linn Gernert, Chunjin Ding, Steven Swanson, Anne B. Need, Theron M. Wall, He Wang, Akihiko Kato, Douglas A. Schober, Ruud Zwart, Benjamin L. Adams, Jeffrey M. Witkin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 369:345-363
Nonselective glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists are efficacious in chronic pain but have significant tolerability issues, likely arising from the ubiquitous expression of AMPA receptors in the
Autor:
Mauro Perretti, Benjamin L. Allen, Raffaele Simeoli, Emanuele Sher, Marzia Malcangio, Jesmond Dalli, Romain A. Colas, Bruno Vilar, Peter A. McNaughton, Silvia Oggero, Karli Montague-Cardoso
Publikováno v:
Pain
Supplemental Digital Content is Available in the Text. In inflammatory arthritis, we show an imbalance of proresolving bioactive lipid mediators in dorsal root ganglia, under persistent nociceptive states, and antinociceptive effects of maresin-1 adm
Autor:
Emanuele Sher, Adrian J. Mogg, Graham N. Wishart, Francesca Pasqui, David A. Evans, Christian C. Felder, Ellen M. Colvin, Ruud Zwart, Helen E. Sanger, Vanessa N. Barth, Lisa M. Broad, Paul Goldsmith
Publikováno v:
British Journal of Pharmacology. 176:110-126
Background and purpose We aimed to identify and develop novel, selective muscarinic M1 receptor agonists as potential therapeutic agents for the symptomatic treatment of Alzheimer's disease. Experimental approach We developed and utilized a novel M1
Autor:
Benjamin Wilenkin, Brian J. Eastwood, Emanuele Sher, Birgit T. Priest, Andrew Caerwyn Williams, Kevin D. Burris
Publikováno v:
Assay and drug development technologies. 17(7)
Relief from chronic pain continues to represent a large unmet need. The voltage-gated potassium channel Kv7.2/7.3, also known as KCNQ2/3, is a key contributor to the control of resting membrane potential and excitability in nociceptive neurons and re