Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Emanuele Monteleone"'
Autor:
Matteo Mazzocca, Alessia Loffreda, Emanuele Colombo, Tom Fillot, Daniela Gnani, Paola Falletta, Emanuele Monteleone, Serena Capozi, Edouard Bertrand, Gaelle Legube, Zeno Lavagnino, Carlo Tacchetti, Davide Mazza
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Nuclear factors rapidly scan the genome for their targets, but the role of nuclear organization in such search is uncharted. Here we analyzed how multiple factors explore chromatin, combining live-cell single-molecule tracking with multifoca
Externí odkaz:
https://doaj.org/article/ad0df2d97361490abffab1918d47a1fd
Autor:
Cise Kizilirmak, Emanuele Monteleone, José Manuel García-Manteiga, Francesca Brambilla, Alessandra Agresti, Marco E. Bianchi, Samuel Zambrano
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108573- (2023)
Summary: Transcription factor dynamics is fundamental to determine the activation of accurate transcriptional programs and yet is heterogeneous at a single-cell level, even within homogeneous populations. We asked how such heterogeneity emerges for t
Externí odkaz:
https://doaj.org/article/d8d217ab7f714702929aaae40e0cd51d
Autor:
Francesca Bersani, Francesca Picca, Deborah Morena, Luisella Righi, Francesca Napoli, Mariangela Russo, Daniele Oddo, Giuseppe Rospo, Carola Negrino, Barbara Castella, Marco Volante, Angela Listì, Vanessa Zambelli, Federica Benso, Fabrizio Tabbò, Paolo Bironzo, Emanuele Monteleone, Valeria Poli, Filippo Pietrantonio, Federica Di Nicolantonio, Alberto Bardelli, Carola Ponzetto, Silvia Novello, Giorgio V. Scagliotti, Riccardo Taulli
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-19 (2023)
Abstract Background MET-driven acquired resistance is emerging with unanticipated frequency in patients relapsing upon molecular therapy treatments. However, the determination of MET amplification remains challenging using both standard and next-gene
Externí odkaz:
https://doaj.org/article/b85e50ab7db14533b177127c3b4c0360
Autor:
Martina Kunkl, Marta Mastrogiovanni, Nicla Porciello, Silvana Caristi, Emanuele Monteleone, Stefano Arcieri, Loretta Tuosto
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
CD28 is an important co-stimulatory receptor for T lymphocytes that, in humans, delivers TCR-independent signal leading to the up-regulation of pro-inflammatory cytokines. We have recently reported that CD28 autonomous signaling induces the expressio
Externí odkaz:
https://doaj.org/article/65434f7d7a0f4cc3a07027357435ae21
Autor:
Paola Circosta, Angela Rita Elia, Indira Landra, Rodolfo Machiorlatti, Maria Todaro, Sabrina Aliberti, Davide Brusa, Silvia Deaglio, Sabina Chiaretti, Riccardo Bruna, Daniela Gottardi, Massimo Massaia, Filomena Di Giacomo, Anna Rita Guarini, Robin Foà, Peter W. Kyriakides, Rohan Bareja, Olivier Elemento, Gurunadh R. Chichili, Emanuele Monteleone, Paul A. Moore, Syd Johnson, Ezio Bonvini, Alessandro Cignetti, Giorgio Inghirami
Publikováno v:
OncoImmunology, Vol 7, Iss 4 (2018)
Many patients with B-cell malignancies can be successfully treated, although tumor eradication is rarely achieved. T-cell-directed killing of tumor cells using engineered T-cells or bispecific antibodies is a promising approach for the treatment of h
Externí odkaz:
https://doaj.org/article/c9f24a2e69284c5786bd71c31922ae7b
Autor:
Matteo Mazzocca, Alessia Loffreda, Emanuele Colombo, Tom Fillot, Daniela Gnani, Paola Falletta, Emanuele Monteleone, Serena Capozi, Edouard Bertrand, Gaelle Legube, Zeno Lavagnino, Carlo Tacchetti, Davide Mazza
Nuclear Factors (NFs) rapidly scan the genome for their targets, but the role of nuclear organization in such search is unexplored. To address this, we combined live-cell single-molecule tracking of NFs with multifocal structured illumination of DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0093f48892d2ca2121ee7e62fd77718
https://doi.org/10.1101/2022.12.29.522193
https://doi.org/10.1101/2022.12.29.522193
Autor:
Lidia Avalle, Laura Raggi, Emanuele Monteleone, Aurora Savino, Daniele Viavattene, Luisa Statello, Andrea Camperi, Simona Aversano Stabile, Vincenzo Salemme, Niccolò De Marzo, Francesca Marino, Chiara Guglielmi, Andrea Lobascio, Cristina Zanini, Marco Forni, Danny Incarnato, Paola Defilippi, Salvatore Oliviero, Valeria Poli
Publikováno v:
ONCOGENE, 41(10), 1456-1467. Nature Publishing Group
In the tumor microenvironment, Cancer Associated Fibroblasts (CAFs) become activated by cancer cells and increase their secretory activity to produce soluble factors that contribute to tumor cells proliferation, invasion and dissemination to distant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86e629c560fcf6df9c432bca5125313
https://research.rug.nl/en/publications/ad3a67a2-10df-41e5-b676-dcb58ab54401
https://research.rug.nl/en/publications/ad3a67a2-10df-41e5-b676-dcb58ab54401
Autor:
Anais Wanet, Mee Rie Sheen, Colyn Crane Robinson, Simone Ummarino, Daniel G. Tenen, Danielle Tenen, Vladimir Espinosa Angarica, Emanuele Monteleone, Valeria Poli, Annalisa Di Ruscio, Touati Benoukraf, Alexander K. Ebralidze, Rory Coffey, Mahmoud A. Bassal, Yanjing Liu, Bogdan Budnik, Haoran Zhang, Roberto Tirado Magallanes, Bon Q. Trinh, Yanzhou Zhang, Dennis Kappei
The mechanisms by which epigenetic modifications are established in gene regulatory regions of active genes remain poorly understood. The data presented show that the establishment and recycling of a major epigenetic mark, the acetylated form of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1af549d22709d0581c94d37ed16f9c5
https://doi.org/10.1101/2021.10.27.466094
https://doi.org/10.1101/2021.10.27.466094
Autor:
Simone Ummarino, Daniel G. Tenen, A Di Ruscio, Emanuele Monteleone, Alex Ebralidze, Yanzhou Zhang, Bon Q. Trinh
The mechanistic events leading to alterations of DNA replication in normal and diseased cells remain unknown. The present study uncovers the role of a new class of non-coding RNAs induced in early S-phase, able to activate and repress replication ori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c96dc35fb85feb150a424d1e7f603487
https://doi.org/10.1101/2021.10.19.465050
https://doi.org/10.1101/2021.10.19.465050
Autor:
Cise Kizilirmak, Emanuele Monteleone, José Manuel García-Manteiga, Francesca Brambilla, Alessandra Agresti, Marco E. Bianchi, Samuel Zambrano
Transcription factor dynamics is fundamental to determine the activation of accurate transcriptional programs and yet is heterogeneous at single-cell level, even between very similar cells. We asked how such heterogeneity emerges for the nuclear fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ff9249059f2df4a2e7ec0520ee1cc8