Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Emanuele M. Gargano"'
Autor:
Rolf W. Hartmann, Chris J. van Koppen, Matthias W. Laschke, Giuseppe Felice Mangiatordi, Ahmed S. Abdelsamie, Martin Frotscher, Orazio Nicolotti, Abdelrahman Mohamed, Angelo Carotti, Arcangela Mazzini, Hanna Drzewiecka, Emanuele M. Gargano, Paweł P. Jagodziński, Sandrine Marchais-Oberwinkler
Publikováno v:
ACS medicinal chemistry letters
United States
ACS Med Chem Lett
ACS medicinal chemistry letters (2021). doi:10.1021/acsmedchemlett.1c00462
info:cnr-pdr/source/autori:Emanuele M. Gargano, Abdelrahman Mohamed, Ahmed S. Abdelsamie, Giuseppe F. Mangiatordi, Hanna Drzewiecka, Pawe? P. Jagodzi?ski, Arcangela Mazzini, Chris J. van Koppen, Matthias W. Laschke, Orazio Nicolotti, Angelo Carotti, Sandrine Marchais-Oberwinkler, Rolf W. Hartmann, and Martin Frotscher/titolo:17?-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer/doi:10.1021%2Facsmedchemlett.1c00462/rivista:ACS medicinal chemistry letters/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
United States
ACS Med Chem Lett
ACS medicinal chemistry letters (2021). doi:10.1021/acsmedchemlett.1c00462
info:cnr-pdr/source/autori:Emanuele M. Gargano, Abdelrahman Mohamed, Ahmed S. Abdelsamie, Giuseppe F. Mangiatordi, Hanna Drzewiecka, Pawe? P. Jagodzi?ski, Arcangela Mazzini, Chris J. van Koppen, Matthias W. Laschke, Orazio Nicolotti, Angelo Carotti, Sandrine Marchais-Oberwinkler, Rolf W. Hartmann, and Martin Frotscher/titolo:17?-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer/doi:10.1021%2Facsmedchemlett.1c00462/rivista:ACS medicinal chemistry letters/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
[Image: see text] In the face of the clinical challenge posed by non-small cell lung cancer (NSCLC), the present need for new therapeutic approaches is genuine. Up to now, no proof existed that 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b72b1eb9a0d3948ea61df325c6e341e
https://hdl.handle.net/10033/623149
https://hdl.handle.net/10033/623149
Autor:
Emanuele M Gargano, Giuseppe Allegretta, Enrico Perspicace, Angelo Carotti, Chris Van Koppen, Martin Frotscher, Sandrine Marchais-Oberwinkler, Rolf W Hartmann
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134754 (2015)
Design and synthesis of a new class of inhibitors for the treatment of osteoporosis and its comparative h17β-HSD2 and m17β-HSD2 SAR study are described. 17a is the first compound to show strong inhibition of both h17β-HSD2 and m17β-HSD2, intracel
Externí odkaz:
https://doaj.org/article/0bc4d2b54c854517a63ff00bf9fcb5c9
Autor:
Emanuele M. Gargano, Giuseppe Felice Mangiatordi, Carsten Goebel, Domenico Alberga, Stefan Wierlacher, Wolfgang Ruess, Orazio Nicolotti, Ingo Weber
Publikováno v:
ChemistryOpen
The stability and unconventional reactivity of 1,13‐diamino‐4,7,10‐trioxatridecane in the presence of NH3, H2O2, and (NH4)2S2O8 are described. The ether‐diamine is an ingredient marketed to hair salons and consumers for so‐called “plex”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f59e074873fc74b4ebc16ed1e02536
http://europepmc.org/articles/PMC5931532
http://europepmc.org/articles/PMC5931532
Autor:
Daniel Neumann, Emanuele M. Gargano, Kimberly Zupko, Valerie Politano, Helga Rothe, Kirstin Kosemund-Meynen, Carsten Goebel, Sheppard Martin, Neelam Jaiswal, Jin Zhang, Gábor von Bölcshazy
Publikováno v:
Current Opinion in Toxicology. 5:46-54
A key part of the safety assessment for cosmetic ingredients is the evaluation of skin sensitization, i.e. their potency to induce an immune response in the skin involving the innate and the adaptive immune system. For decades the murine local lymph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b3efd8f942a0f77917234ff1e2079d4
https://doi.org/10.1016/j.cotox.2017.08.005
https://doi.org/10.1016/j.cotox.2017.08.005
Autor:
Martin Frotscher, Ahmed S. Abdelsamie, Emanuele M. Gargano, Martin Empting, Emmanuel Bey, Chris J. van Koppen
Publikováno v:
European Journal of Medicinal Chemistry. 103:56-68
17β-Estradiol (E2), the most potent human estrogen, is known to be involved in the etiology of estrogen-dependent diseases (EDD) like breast cancer and endometriosis. 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyses the last step of E2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cdc68e3a04485060a66e3174b7f570e
https://doi.org/10.1016/j.ejmech.2015.08.030
https://doi.org/10.1016/j.ejmech.2015.08.030
Autor:
Stefan Hinsberger, Rolf W. Hartmann, Emanuele M. Gargano, Marie Wetzel, Sandrine Marchais-Oberwinkler
Publikováno v:
European Journal of Medicinal Chemistry. 47:1-17
E2 deficiency in elderly people has directly an effect on the skeleton and can lead to osteoporosis. As 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) catalyses the conversion between active 17β-hydroxysteroid estradiol (E2) and testosterone (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d229ca07fca7e00a9c0489631e86e3
https://doi.org/10.1016/j.ejmech.2011.09.004
https://doi.org/10.1016/j.ejmech.2011.09.004
Autor:
Emanuele M. Gargano, Giuseppe Felice Mangiatordi, Ingo Weber, Wolfgang Ruess, Orazio Nicolotti, Stefan Wierlacher, Carsten Goebel, Domenico Alberga
Publikováno v:
ChemistryOpen
The Cover Feature shows a persulfate reaction occurring under the conditions of a cosmetic hair bleaching procedure, applied worldwide to lighten hair. 1,13‐diamino‐4,7,10‐trioxatridecane is an ingredient marketed to hair salons and consumers f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093db839fe8d4c3b8397345160a43b54
https://doi.org/10.1002/open.201800052
https://doi.org/10.1002/open.201800052
Autor:
Rolf W. Hartmann, Sandrine Marchais-Oberwinkler, Enrico Perspicace, Emanuele M. Gargano, Angelo Carotti
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(1)
Four different classes of new 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors were synthesized, in order to lower the cytotoxicity exhibited by the lead compound A, via disrupting the linearity and the aromaticity of the biphenyl moie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de18324b6f126fe748b3d38b8516b4eb
https://pubmed.ncbi.nlm.nih.gov/26615885
https://pubmed.ncbi.nlm.nih.gov/26615885
Autor:
Emanuele M. Gargano, Enrico Perspicace, Angelo Carotti, Rolf W. Hartmann, Sandrine Marchais-Oberwinkler, Nina Hanke
Publikováno v:
European journal of medicinal chemistry. 87
17β-HSD2 is a promising new target for the treatment of osteoporosis. In this paper, a rational strategy to overcome the metabolic liability in the 2,5-thiophene amide class of 17β-HSD2 inhibitors is described, and the biological activity of the ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020cad006156eaa13b93cf0108e7e2e0
https://pubmed.ncbi.nlm.nih.gov/25259513
https://pubmed.ncbi.nlm.nih.gov/25259513
Autor:
Nina Hanke, Emanuele M. Gargano, Enrico Perspicace, Rolf W. Hartmann, Sandrine Marchais-Oberwinkler, Angelo Carotti, Liliana Cozzoli
Publikováno v:
European journal of medicinal chemistry. 83
17β-Hydroxysteroid dehydrogenase type 2 (17β-HSD2) is responsible for the oxidation of the highly active estradiol (E2) and testosterone (T) into the less potent estrone (E1) and Δ4-androstene-3,17-dione (Δ4-AD), respectively. As 17β-HSD2 is pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a74c144421a220184d9b0643de195e
https://pubmed.ncbi.nlm.nih.gov/24974351
https://pubmed.ncbi.nlm.nih.gov/24974351