Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Emanuele Bernardinelli"'
Autor:
Andreas Konopa, Melanie A. Meier, Miriam J. Franz, Emanuele Bernardinelli, Anna-Lena Voegele, Raja Atreya, Silvia Ribback, Stephanie Roessler, Achim Aigner, Kerstin Singer, Stephan Singer, Antonio Sarikas, Susanne Muehlich
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-12 (2022)
Abstract Myocardin-related transcription factors A and B (MRTFs) are coactivators of Serum Response Factor (SRF), which controls fundamental biological processes such as cell growth, migration, and differentiation. MRTF and SRF transcriptional activi
Externí odkaz:
https://doaj.org/article/470cbd2eb6b54616968344e265c1703a
Autor:
Emanuele Bernardinelli, Sebastian Roesch, Edi Simoni, Angela Marino, Gerd Rasp, Laura Astolfi, Antonio Sarikas, Silvia Dossena
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Hearing loss (HL) is the most common sensory defect and affects 450 million people worldwide in a disabling form. Pathogenic sequence alterations in the POU3F4 gene, which encodes a transcription factor, are causative of the most common type of X-lin
Externí odkaz:
https://doaj.org/article/b0ce63a6409749afb9a0d8221bd06859
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1695 (2023)
X-linked deafness (DFNX) is estimated to account for up to 2% of cases of hereditary hearing loss and occurs in both syndromic and non-syndromic forms. POU3F4 is the gene most commonly associated with X-linked deafness (DFNX2, DFN3) and accounts for
Externí odkaz:
https://doaj.org/article/9b3e2f378ef04599936a09fa0e33a881
Autor:
Roberta Costa, Alessia Remigante, Davide A. Civello, Emanuele Bernardinelli, Zoltán Szabó, Rossana Morabito, Angela Marino, Antonio Sarikas, Wolfgang Patsch, Markus Paulmichl, Tamás Janáky, Attila Miseta, Tamás Nagy, Silvia Dossena
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
O-GlcNAcylation is a post-translational modification of proteins that controls a variety of cellular processes, is chronically elevated in diabetes mellitus, and may contribute to the progression of diabetic complications, including diabetic nephropa
Externí odkaz:
https://doaj.org/article/b6a4902b909a460ead747eda5555f44b
Autor:
Roberta Costa, Davide Antonio Civello, Emanuele Bernardinelli, Simone Vanoni, Michaela Zopf, Giada Scantamburlo, Charity Nofziger, Wolfgang Patsch, Markus Paulmichl, Silvia Dossena
Publikováno v:
Cellular Physiology and Biochemistry, Vol 45, Iss 3, Pp 867-882 (2018)
Background/Aims: In the human genome, more than 400 genes encode ion channels, which are ubiquitously expressed and often coexist and participate in almost all physiological processes. Therefore, ion channel blockers represent fundamental tools in di
Externí odkaz:
https://doaj.org/article/c37c0e4fd1974ea4a2960f2d2918de51
Autor:
Giada Scantamburlo, Konstantina Tziolia, Michaela Zopf, Emanuele Bernardinelli, Selma M. Soyal, Davide Antonio Civello, Simone Vanoni, Silvia Dossena, Wolfgang Patsch, George P. Patrinos, Markus Paulmichl, Charity Nofziger
Publikováno v:
Cellular Physiology and Biochemistry, Vol 43, Iss 6, Pp 2297-2309 (2017)
Background/Aim: Accurate genotyping of CYP2D6 is challenging due to its inherent genetic variation, copy number variation (duplications and deletions) and hybrid formation with highly homologous pseudogenes. Because a relatively high percentage (∼2
Externí odkaz:
https://doaj.org/article/9cde00b26d2b41e99c6204971491637b
Autor:
Giada Scantamburlo, Simone Vanoni, Silvia Dossena, Selma M. Soyal, Emanuele Bernardinelli, Davide Antonio Civello, Wolfgang Patsch, Markus Paulmichl, Charity Nofziger
Publikováno v:
Cellular Physiology and Biochemistry, Vol 41, Iss 4, Pp 1491-1502 (2017)
Pendrin is upregulated in bronchial epithelial cells following IL-4 stimulation via binding of STAT6 to an N4 GAS motif. Basal CpG methylation of the pendrin promoter is cell-specific. We studied if a correlation exists between IL-4 sensitivity and t
Externí odkaz:
https://doaj.org/article/8c5b99ad4f4443248f99c4526ecf4c56
Autor:
Markus Kwik, Stefan Hainzl, Jan Oppelt, Boris Tichy, Ulrich Koller, Emanuele Bernardinelli, Markus Steiner, Greta Zara, Charity Nofziger, Serge Weis, Markus Paulmichl, Silvia Dossena, Wolfgang Patsch, Selma M. Soyal
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3296 (2021)
The transcriptional regulator peroxisome proliferator activated receptor gamma coactivator 1A (PGC-1α), encoded by PPARGC1A, has been linked to neurodegenerative diseases. Recently discovered CNS-specific PPARGC1A transcripts are initiated far upstr
Externí odkaz:
https://doaj.org/article/46c4e45c19ba46d1b98f3e9f3b1a9a0c
Publikováno v:
Cellular Physiology and Biochemistry, Vol 38, Iss 5, Pp 1984-1998 (2016)
Background/Aims: Pendrin is a Cl-/I-/HCO3- exchanger playing a fundamental role in controlling blood pressure and airway function, therefore representing an attractive target for the treatment of hypertensive states and respiratory distresses. A revi
Externí odkaz:
https://doaj.org/article/1a11caa62f3f455fb5837a27780d4683
Autor:
Vanessa C S de Moraes, Emanuele Bernardinelli, Nathalia Zocal, Jhonathan A Fernandez, Charity Nofziger, Arthur M Castilho, Edi L Sartorato, Markus Paulmichl, Silvia Dossena
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 41-53 (2016)
Abstract Sequence alterations in the pendrin gene (SLC26A4) leading to functionally affected protein variants are frequently involved in the pathogenesis of syndromic and nonsyndromic deafness. Considering the high number of SLC26A4 sequence alterati
Externí odkaz:
https://doaj.org/article/88b48615ee4a46489d266e59a5678e87