Výsledky vyhledávání - "Emanuele Arrabito"

Mas Receptor Activation Contributes to the Improvement of Nitric Oxide Bioavailability and Vascular Remodeling During Chronic AT1R (Angiotensin Type-1 Receptor) Blockade in Experimental Hypertension

Autor: Carmine Nicoletti, Emanuele Arrabito, Rhian M. Touyz, Antonio Filippini, Massimo Volpe, Carmine Savoia, Allegra Battistoni, Luca Madaro, Rosa Parente, Ulrike Muscha Steckelings

Publikováno v: Savoia, C, Arrabito, E, Parente, R, Nicoletti, C, Madaro, L, Battistoni, A, Filippini, A, Steckelings, U M, Touyz, R M & Volpe, M 2020, ' Mas Receptor Activation Contributes to the Improvement of Nitric Oxide Bioavailability and Vascular Remodeling During Chronic AT1R (Angiotensin Type-1 Receptor) Blockade in Experimental Hypertension ', Hypertension, vol. 76, no. 6, pp. 1753-1761 . https://doi.org/10.1161/HYPERTENSIONAHA.120.15527

Angiotensin (1–7) production increases during AT1R (angiotensin type-1 receptor) blockade. The contribution of Ang (1–7) (angiotensin [1–7]) and its receptor (MasR) to the favorable effect of angiotensin receptor blockers on remodeling and func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3737c2d1c72b76340b2530c9e771c7f
https://doi.org/10.1161/hypertensionaha.120.15527

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Effect of direct renin inhibition on vascular function after long-term treatment with aliskiren in hypertensive and diabetic patients

Autor: Maria Lorenza Muiesan, Allegra Battistoni, Carmine Savoia, Raffaella Carletti, Massimo Salvetti, Paolo Mercantini, Massimo Volpe, Carolina De Ciuceis, Sarassunta Ucci, Emanuele Arrabito, Anna Paini, Antonio Filippini, Damiano Rizzoni, Cira Di Gioia, Carmine Nicoletti, Enrico Agabiti Rosei

Publikováno v: Journal of Hypertension. 39:169-180

Objective We tested the hypothesis that chronic treatment with the direct renin inhibitor aliskiren improves vascular function in resistance and conduit arteries of type two diabetic and hypertensive patients. Method Sixteen patients with mild essent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fbf5b251f63e8c15511b814b70af07
https://doi.org/10.1097/hjh.0000000000002595

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Abstract P346: Endothelial Function and NO Bioavailability are Improved in Angiotensin Ii-treated Transglutaminase-2 Knock-out Mice

Autor: Cira Di Gioia, Raffaella Carletti, Carmine Savoia, Emanuele Arrabito, Sergio Chiandotto, Massimo Volpe, Carmine Nicoletti

Publikováno v: Hypertension. 68

We hypothesized that transglutaminase-2 (TG2) may contribute to the impaired functional properties of resistance arteries from angiotensin-II-treated mice. TG2-knockout mice (TG2-K/O, 12 weeks old, n=6) and wild type (WT) mice were treated or not wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82b94f026cf0a25fd2e01d37e23e46ec
https://doi.org/10.1161/hyp.68.suppl_1.p346

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Abstract 024: The Direct Renin Inhibitor Aliskiren Improves Vasodilation and Endothelial Function in Resistance Arteries from Diabetic and Hypertensive Patients

Autor: Carmine Savoia, Carolina De Ciuceis, Emanuele Arrabito, Anna Paini, Lidia Sada, Carmine Nicoletti, Raffaella Carletti, Damiano Rizzoni, Maria Lorenza Muiesan, Cira Di Giioia, Enrico Agabiti Rosei, Massimo Volpe

Publikováno v: Hypertension. 66

We previously demonstrated that the direct renin inhibitor aliskiren (ALK) significantly reduced the remodeling of subcutaneous resistance arteries of hypertensive patients as compared to the angiotensin-converting enzyme inhibitor ramipril (RAM). He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c56a3347f1ea21bda444c878d82f7007
https://doi.org/10.1161/hyp.66.suppl_1.024

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Abstract MP10: Early Functional and Structural Alterations of Resistance Arteries in Mice Treated with an Inhibitor of the Vascular Endothelial Growth Factor Receptor

Autor: CARMINE SAVOIA, Emanuele Arrabito, Augusto C Montezano, Carmine Nicoletti, Heather Y Small, Lidia Sada, Francisco Rios, Massimo Volpe, Rhian M Touyz

Publikováno v: Hypertension. 64

Background: Inhibition of tyrosine kinases receptors such as vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) improves outcomes in patients with cancers. Only VEGFR inhibitors, however, induce severe hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f572ed5f7bf2a83719691ce9e7d36f3c
https://doi.org/10.1161/hyp.64.suppl_1.mp10

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Abstract 45: Reduced Vascular Remodeling and Improved Endothelial Function in Transglutaminase 2 Knock-Out Mice Treated with Angiotensin II

Autor: Carmine Savoia, Emanuele Arrabito, Lidia Sada, Serena Michelini, Lorenzo Pucci, Martina Briani, Carmine Nicoletti, Eleonora Candi, Ernesto L Schiffrin, Massimo Volpe

Publikováno v: Hypertension. 62

Transglutaminase 2 (TG2) may modulate cell-matrix interactions by inducing cross-linking of proteins. We previously demonstrated that angiotensin II (Ang II) positively regulated TG2 expression in vascular smooth muscle cells from SHR. Here we hypoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53b689efbcf9926255bd891d678c0146
https://doi.org/10.1161/hyp.62.suppl_1.a45

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Abstract 406: Improved Angiotensin II Type 2 Receptor Expression and Function in Transglutaminase 2 Knock-Out Mice Treated with Angiotensin II

Autor: Carmine Savoia, Emanuele Arrabito, Lidia Sada, Serena Michelini, Lorenzo Pucci, Martina Briani, Carmine Nicoletti, Eleonora Candi, Ulrike M Steckelings, Ernesto L Schiffrin, Massimo Volpe

Publikováno v: Hypertension. 62

Objective: Transglutaminase 2 (TG2) induces transamidation and cross-linking of proteins that can modulate receptor interaction. Angiotensin II (AngII) may regulate TG2 and AngII type 2 receptor (AT2) expression and function. We hypothesized that Ang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12445e1cc2f79a4e81cf623a92717afb
https://doi.org/10.1161/hyp.62.suppl_1.a406

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The direct renin inhibitor aliskiren improves vascular remodelling in transgenic rats harbouring human renin and angiotensinogen genes

Autor: Rosa Parente, Luigi Zezza, Carmine Nicoletti, Dominik N. Müller, Carmine Savoia, Lidia Sada, Alessandro Alonzo, Massimo Volpe, Speranza Rubattu, Luca Madaro, Emanuele Arrabito, S Michelini

In the present study, we tested the hypothesis that chronic treatment with the direct rennin inhibitor aliskiren improves the remodelling of resistance arteries in dTGR (double-transgenic rats). dTGR (5 weeks) were treated with aliskiren (3 mg/kg of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db48250248b9315216c9e0d6a6aa6466
http://hdl.handle.net/11382/524538

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