Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Emanuela Sega"'
Autor:
Alvaro Teijeira, Arantza Azpilikueta, Emanuela Sega, James West, Ignacio Melero, Iñaki Etxeberria, Maria C. Ochoa, Elixabet Bolaños, Maria Rodriguez, John J. Engelhardt, Saray Garasa, Bryan Irving, Alba Yanguas, Marcia Belvin, Kimberly Ann Tipton, Bruce Howng, Ana Melero, Olga Vasiljeva, Li Mei, Assunta Cirella, Korman Alan J, Miguel F. Sanmamed, Irene Olivera, William M. Kavanaugh
Publikováno v:
Proc Natl Acad Sci U S A
Costimulation via CD137 (4-1BB) enhances antitumor immunity mediated by cytotoxic T lymphocytes. Anti-CD137 agonist antibodies elicit mild liver inflammation in mice, and the maximum tolerated dose of Urelumab, an anti-human CD137 agonist monoclonal
Autor:
Rony Dahan, Emanuela Sega, Jeffrey V. Ravetch, Mark J. Selby, John J. Engelhardt, Alan J. Korman
Publikováno v:
Cancer Cell. 28:285-295
SummaryImmune checkpoint blockade of the programmed cell death protein 1 (PD-1) pathway by monoclonal antibodies (Abs) has shown promising clinical benefit in the treatment of multiple cancer types. We elucidated the contribution of the fragment crys
Autor:
Lillian L. Siu, Emanuela Sega, Dung T. Le, Richard D. Carvajal, Cyrus Hedvat, Jean-Pierre Delord, Anke Klippel, John Hilton, Bryan C. Barnhart, Ed Hilt, Yue Zhao, Antoine Hollebecque, Howard A. Burris, P. Basciano, Kinjal Sanghavi, Jennifer Postelnek, Mark Donovan, Raymond P. Perez, Neeltje Steeghs, Adrianna Gipson
Publikováno v:
Cancer Research. 78:CT180-CT180
Background: CD73 is an ectonucleotidase that converts adenosine monophosphate to adenosine, a potent immunosuppressive soluble mediator that inhibits the cytotoxic function of CD8+ T cells and natural killer cells while promoting proliferation of imm
Autor:
Aaron P. Yamniuk, Haben Ghermazien, Anne Lewin, Pingping Zhang, Alan J. Korman, Emanuela Sega, Ming Lei, Xi-Tao Wang, Bryan C. Barnhart, Haichun Huang, Sandra V. Hatcher
Publikováno v:
Cancer Research. 76:1476-1476
CD73 has a central role in dictating the adenosine concentration within the tumor as it is the final step in converting extracellular ATP to adenosine. Thus, substantial reduction of CD73 enzymatic activity has the potential to reduce immunosuppressi