Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Emanuela Romano"'
Autor:
Hugo Croizer, Rana Mhaidly, Yann Kieffer, Geraldine Gentric, Lounes Djerroudi, Renaud Leclere, Floriane Pelon, Catherine Robley, Mylene Bohec, Arnaud Meng, Didier Meseure, Emanuela Romano, Sylvain Baulande, Agathe Peltier, Anne Vincent-Salomon, Fatima Mechta-Grigoriou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-28 (2024)
Abstract Although heterogeneity of FAP+ Cancer-Associated Fibroblasts (CAF) has been described in breast cancer, their plasticity and spatial distribution remain poorly understood. Here, we analyze trajectory inference, deconvolute spatial transcript
Externí odkaz:
https://doaj.org/article/73b3042cd19346fdaed2121d0b1ae858
Autor:
Laurence Buisseret, Delphine Loirat, Philippe Aftimos, Christian Maurer, Kevin Punie, Véronique Debien, Paulus Kristanto, Daniel Eiger, Anthony Goncalves, François Ghiringhelli, Donatienne Taylor, Florent Clatot, Tom Van den Mooter, Jean-Marc Ferrero, Hervé Bonnefoi, Jean-Luc Canon, Francois P. Duhoux, Laura Mansi, Renaud Poncin, Philippe Barthélémy, Nicolas Isambert, Zoë Denis, Xavier Catteau, Roberto Salgado, Elisa Agostinetto, Evandro de Azambuja, Françoise Rothé, Ligia Craciun, David Venet, Emanuela Romano, John Stagg, Marianne Paesmans, Denis Larsimont, Christos Sotiriou, Michail Ignatiadis, Martine Piccart-Gebhart
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Chemo-immunotherapy is the first-line standard of care for patients with PD-L1 positive metastatic triple-negative breast cancer (mTNBC). SYNERGY (NCT03616886) is a dose-finding phase I and a randomized phase II, open-label trial evaluating
Externí odkaz:
https://doaj.org/article/50f0c9a693404d0bbb0bf5ae3d4ee9c1
Autor:
Martine Piccart-Gebhart, Emanuela Romano, Christos Sotiriou, Marianne Paesmans, Ligia Craciun, Denis Larsimont, Roberto Salgado, Elisa Agostinetto, Laurence Buisseret, Isabelle Veys, Alex de Caluwé, Philip Poortmans, Andrea Gombos, Guilherme Nader Marta, Zoe Denis, Stylianos Drisis, Christophe Vandekerkhove, Antoine Desmet, Catherine Philippson, Dirk Van Gestel, Michail Ignatiadis
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 12 (2023)
Background Luminal B breast cancer (BC) presents a worse prognosis when compared with luminal A BC and exhibits a lower sensitivity to chemotherapy and a lower immunogenicity in contrast to non-luminal BC subtypes. The Neo-CheckRay clinical trial inv
Externí odkaz:
https://doaj.org/article/a5ee6654546a4d7e98521bceca85490a
Autor:
Manuel Rodrigues, Giulia Vanoni, Pierre Loap, Coraline Dubot, Eleonora Timperi, Mathieu Minsat, Louis Bazire, Catherine Durdux, Virginie Fourchotte, Enora Laas, Nicolas Pouget, Zahra Castel-Ajgal, Gregoire Marret, Laetitia Lesage, Didier Meseure, Anne Vincent-Salomon, Lolita Lecompte, Nicolas Servant, Sophie Vacher, Ivan Bieche, Caroline Malhaire, Virginie Huchet, Laurence Champion, Maud Kamal, Sebastian Amigorena, Olivier Lantz, Marion Chevrier, Emanuela Romano
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Concurrent chemoradiotherapy (CRT) with blockade of the PD-1 pathway may enhance immune-mediated tumor control through increased phagocytosis, cell death, and antigen presentation. The NiCOL phase 1 trial (NCT03298893) is designed to determi
Externí odkaz:
https://doaj.org/article/ae19c89ecebf4147acfd3e5c2acc5362
Autor:
Véronique Debien, Alex De Caluwé, Xiaoxiao Wang, Martine Piccart-Gebhart, Vincent K. Tuohy, Emanuela Romano, Laurence Buisseret
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Recent progress in immunobiology has led the way to successful host immunity enhancement against breast cancer. In triple-negative breast cancer, the combination of cancer immunotherapy based on PD-1/PD-L1 immune checkpoint inhibitors with c
Externí odkaz:
https://doaj.org/article/7616f38e2956432d86f0f5dcf1473292
Autor:
Laurence Buisseret, Delphine Loirat, Philippe Aftimos, Christian Maurer, Kevin Punie, Véronique Debien, Paulus Kristanto, Daniel Eiger, Anthony Goncalves, François Ghiringhelli, Donatienne Taylor, Florent Clatot, Tom Van den Mooter, Jean-Marc Ferrero, Hervé Bonnefoi, Jean-Luc Canon, Francois P. Duhoux, Laura Mansi, Renaud Poncin, Philippe Barthélémy, Nicolas Isambert, Zoë Denis, Xavier Catteau, Roberto Salgado, Elisa Agostinetto, Evandro de Azambuja, Françoise Rothé, Ligia Craciun, David Venet, Emanuela Romano, John Stagg, Marianne Paesmans, Denis Larsimont, Christos Sotiriou, Michail Ignatiadis, Martine Piccart-Gebhart
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/1872bd3c329443328fa10ee0e5e38651
Autor:
Eleonora Timperi, Emanuela Romano
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The tumor associated macrophages (TAM) represent one of most abundant subpopulations across several solid cancers and their number/frequency is associated with a poor clinical outcome. It has been clearly demonstrated that stromal cells, such as the
Externí odkaz:
https://doaj.org/article/9346a8714a624cdab613d97d6a1ee276
Autor:
Joan Brunet, Josep Tabernero, Salvatore Grisanti, Matteo Lambertini, George Pentheroudakis, Bruno Vincenzi, Dirk Arnold, Juan Aguilar-Company, Paolo Pedrazzoli, Solange Peters, Luis Castelo-Branco, Emanuela Romano, Olivier Michielin, Ramon Salazar, Alessio Cortellini, Rossana Berardi, Aleix Prat, Spyridon Gennatas, Giuseppe Tonini, Urania Dafni, Kevin J Harrington, Paola Queirolo, David J Pinato, Francesca Mazzoni, David Viñal, Gino M Dettorre, Uma Mukherjee, Mark Bower, Alexia Bertuzzi, Ailsa Sita-Lumsden, Federica Biello, Andrea Patriarca, Alessandra Gennari, Maura Rossi, Zoi Tsourti, Vasileios Angelis, Jacobo Rogado, Teresa Alonso-Gordoa, Georgia Dimopoulou, Sylvain Pradervand, Marco Tucci, Fanny Pommeret, Marco Krengli
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)
Background As management and prevention strategies against COVID-19 evolve, it is still uncertain whether prior exposure to immune checkpoint inhibitors (ICIs) affects COVID-19 severity in patients with cancer.Methods In a joint analysis of ICI recip
Externí odkaz:
https://doaj.org/article/b011e59004e14e2dab36152831044c2b
Autor:
Alex De Caluwé, Laurence Buisseret, Philip Poortmans, Dirk Van Gestel, Roberto Salgado, Christos Sotiriou, Denis Larsimont, Marianne Paesmans, Ligia Craciun, Drisis Stylianos, Christophe Vandekerckhove, Fabien Reyal, Veys Isabelle, Daniel Eiger, Martine Piccart, Emanuela Romano, Michail Ignatiadis
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Residual breast cancer after neo-adjuvant chemotherapy (NACT) predicts disease outcome and is a surrogate for survival in aggressive breast cancer (BC) subtypes. Pathological complete response (pCR) rate, however, is lower for lum
Externí odkaz:
https://doaj.org/article/77e1e848595f46df8edd12cb7e91b490
Autor:
Xiaoxiao Wang, Laetitia Collet, Mattia Rediti, Véronique Debien, Alex De Caluwé, David Venet, Emanuela Romano, Françoise Rothé, Christos Sotiriou, Laurence Buisseret
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 3, p 953 (2023)
Triple negative breast cancer (TNBC) is a highly heterogeneous disease with a poor prognosis and a paucity of therapeutic options. In recent years, immunotherapy has emerged as a new treatment option for patients with TNBC. However, this therapeutic
Externí odkaz:
https://doaj.org/article/f2522b5f228a4bd6aa7616744b6bbde5