Ghrelin Increases Beta-Catenin Level through Protein Kinase A Activation and Regulates OPG Expression in Rat Primary Osteoblasts

Autor: Emanuela Mrak, Lavinia Casati, Francesca Pagani, Alessandro Rubinacci, Guido Zarattini, Valeria Sibilia

Publikováno v: International Journal of Endocrinology, Vol 2015 (2015)

Ghrelin, by binding growth hormone secretagogue receptor (GHS-R), promotes osteoblast proliferation but the signaling mechanism of GHS-R on these cells remains unclear. Since canonical Wnt/β-catenin pathway is critically associated with bone homeost

Externí odkaz: https://doaj.org/article/f104774447024680894976de246acdea

Microarray analysis of 1,25(OH)2D3 regulated gene expression in human primary osteoblasts

Autor: Michela Mattioli, Alessandro Rubinacci, Emanuela Mrak, Isabella Villa, Francesca Zolezzi, Claudio Gattuso, Paola Tarroni

Publikováno v: Journal of Cellular Biochemistry. 113:640-649

Though extensive studies have been conducted, questions regarding the molecular effectors and pathways underlying the regulatory role of 1,25(OH)2D3 in human osteoblasts other than cell differentiation and matrix protein production remain unanswered.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::182eca24f644681372a1eeb3b5afdeb1
https://doi.org/10.1002/jcb.23392

Urokinase Plasminogen Activator Receptor Affects Bone Homeostasis by Regulating Osteoblast and Osteoclast Function

Autor: Federico Furlan, Francesco Blasi, Pasquale Verde, Clara Galbiati, Jens Erik Beck Jensen, Emanuela Mrak, Niklas Rye Jørgensen, Alessandro Rubinacci, Francesco Talotta

Publikováno v: Journal of bone and mineral research 22 (2007): 1387–1396. doi:10.1359/JBMR.070516
info:cnr-pdr/source/autori:Furlan F.; Galbiati C.; Jorgensen N.R.; Jensen JE.; Mrak E.; Rubinacci A.; Talotta F.; Verde P.; Blasi F./titolo:Urokinase plasminogen activator receptor affects bone homeostasis by regulating osteoblast and osteoclast/doi:10.1359%2FJBMR.070516/rivista:Journal of bone and mineral research/anno:2007/pagina_da:1387/pagina_a:1396/intervallo_pagine:1387–1396/volume:22

The uPAR and its ligand uPA are expressed by both osteoblasts and osteoclasts. Their function in bone remodeling is unknown. We report that uPAR-lacking mice display increased BMD, increased osteogenic potential of osteoblasts, decreased osteoclasts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b437a24ac53c469c59bb9963b2e8e26
https://doi.org/10.1359/jbmr.070516

Dietary tryptophan manipulation reveals a central role for serotonin in the anabolic response of appendicular skeleton to physical activity in rats

Autor: Emanuela Mrak, Marcella Marchese, Valeria Sibilia, Francesca Pagani, Guido Zarattini, Francesca Guidobono, Elisa Dieci

Several studies support a serotonin role in the physiological control of bone mass. However, whether serotonin (5-HT) is involved in bone loss due to reduced mechanical stress or unloading is unknown. We investigated the effects of reduced 5-HT tone,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483ac0ebaac00c76df6c2b99e641da7e
http://hdl.handle.net/2434/225278

Microarray analysis of 1,25(OH)₂D₃ regulated gene expression in human primary osteoblasts

Autor: Paola, Tarroni, Isabella, Villa, Emanuela, Mrak, Francesca, Zolezzi, Michela, Mattioli, Claudio, Gattuso, Alessandro, Rubinacci

Publikováno v: Journal of cellular biochemistry. 113(2)

Though extensive studies have been conducted, questions regarding the molecular effectors and pathways underlying the regulatory role of 1,25(OH)(2)D(3) in human osteoblasts other than cell differentiation and matrix protein production remain unanswe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef06cc029495cdf8d4897071d2bbdc86
https://pubmed.ncbi.nlm.nih.gov/21956231