Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Emanuela I. Sega"'
Autor:
Emanuela I Sega, Dennis B Leveson-Gower, Mareike Florek, Dominik Schneidawind, Richard H Luong, Robert S Negrin
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86551 (2014)
Lag-3 has emerged as an important molecule in T cell biology. We investigated the role of Lag-3 in conventional T cell (Tcon) and regulatory T cell (Treg) function in murine GVHD with the hypothesis that Lag-3 engagement diminishes alloreactive T cel
Externí odkaz:
https://doaj.org/article/a0faece07ceb4400b242bf8d6059b24b
Autor:
Jeanette Baker, Richard Luong, Janelle A. Olson, Robert Zeiser, Dennis B. Leveson-Gower, Emanuela I. Sega, Robert S. Negrin
Publikováno v:
Blood. 117:3220-3229
CD4+ natural killer T (NKT) cells, along with CD4+CD25+ regulatory T cells (Tregs), are capable of controlling aberrant immune reactions. We explored the adoptive transfer of highly purified (> 95%) CD4+NKT cells in a murine model of allogeneic hemat
Autor:
Emanuela I. Sega, Philip S. Low
Publikováno v:
Cancer and Metastasis Reviews. 27:655-664
Folate receptors are up-regulated on a variety of human cancers, including cancers of the breast, ovaries, endometrium, lungs, kidneys, colon, brain, and myeloid cells of hematopoietic origin. This over-expression of folate receptors (FR) on cancer t
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 71:559-566
Purpose Human cancers frequently overexpress a high-affinity cell-surface receptor for the vitamin folic acid. Highly immunogenic haptens can be targeted to folate receptor–expressing cell surfaces by administration of folate–hapten conjugates, r
Publikováno v:
The AAPS Journal. 8:E466-E478
While modern genomic and proteomic technology enables rapid screening of novel proteins and peptides as potential drug candidates, design of delivery systems for these biologics remains challenging especially to achieve site-specific pharmacological
Publikováno v:
International Journal of Cancer. 116:710-719
We previously exploited the frequent overexpression of folate receptors on cancer cells to decorate malignant cell surfaces selectively with folate-hapten conjugates. In antihapten-immunized hosts, this targeted localization of foreign haptens to tum
Autor:
Antonia M.S. Müller, Everett Meyer, Jeanette Baker, Robert S. Negrin, Emanuela I. Sega, Mareike Florek, Dennis B. Leveson-Gower, Dominik Schneidawind
Publikováno v:
Blood. 124(11)
Acute graft-versus-host disease (GVHD) is induced by alloreactivity of donor T cells toward host antigens presented on antigen-presenting cells (APCs). Apoptotic cells are capable of inducing tolerance by altering APC maturation. Apoptosis can be ind
Autor:
Ho-Jin Shin, Jeanette Baker, Robert S. Negrin, Dennis B. Leveson-Gower, Aaron Smith, Emanuela I. Sega
Publikováno v:
Blood. 118(8)
Previous work has demonstrated that both rapamycin (RAPA) and IL-2 enhance CD4+CD25+Foxp3+ regulatory T-cell (Treg) proliferation and function in vitro. We investigated whether the combination of RAPA plus IL-2 could impact acute GVHD induction after
Autor:
Stephen J. Galli, Mareike Florek, R.S. Negrin, Janet Kalesnikoff, Dennis B. Leveson-Gower, Emanuela I. Sega
Publikováno v:
Biology of Blood and Marrow Transplantation. 17(2)
Publikováno v:
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 17
Naturally occurring regulatory T cells (Treg) are T cells with pivotal immunomodulatory capabilities. Treg cells express CD4, high levels of the IL-2 receptor CD25, and the Treg-specific transcription factor Foxp3, that was previously shown to be suf