Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Emanuela I Sega"'
Autor:
Emanuela I Sega, Dennis B Leveson-Gower, Mareike Florek, Dominik Schneidawind, Richard H Luong, Robert S Negrin
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86551 (2014)
Lag-3 has emerged as an important molecule in T cell biology. We investigated the role of Lag-3 in conventional T cell (Tcon) and regulatory T cell (Treg) function in murine GVHD with the hypothesis that Lag-3 engagement diminishes alloreactive T cel
Externí odkaz:
https://doaj.org/article/a0faece07ceb4400b242bf8d6059b24b
Autor:
Jeanette Baker, Richard Luong, Janelle A. Olson, Robert Zeiser, Dennis B. Leveson-Gower, Emanuela I. Sega, Robert S. Negrin
Publikováno v:
Blood. 117:3220-3229
CD4+ natural killer T (NKT) cells, along with CD4+CD25+ regulatory T cells (Tregs), are capable of controlling aberrant immune reactions. We explored the adoptive transfer of highly purified (> 95%) CD4+NKT cells in a murine model of allogeneic hemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dee28fb4338562002c7eac9c6d0ad1d
https://doi.org/10.1182/blood-2010-08-303008
https://doi.org/10.1182/blood-2010-08-303008
Autor:
Emanuela I. Sega, Philip S. Low
Publikováno v:
Cancer and Metastasis Reviews. 27:655-664
Folate receptors are up-regulated on a variety of human cancers, including cancers of the breast, ovaries, endometrium, lungs, kidneys, colon, brain, and myeloid cells of hematopoietic origin. This over-expression of folate receptors (FR) on cancer t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a1bc7971f900818e51a652217cf9e4
https://doi.org/10.1007/s10555-008-9155-6
https://doi.org/10.1007/s10555-008-9155-6
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 71:559-566
Purpose Human cancers frequently overexpress a high-affinity cell-surface receptor for the vitamin folic acid. Highly immunogenic haptens can be targeted to folate receptor–expressing cell surfaces by administration of folate–hapten conjugates, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefa10147782a40dd0e583d2517d1506
https://doi.org/10.1016/j.ijrobp.2008.02.010
https://doi.org/10.1016/j.ijrobp.2008.02.010
Publikováno v:
The AAPS Journal. 8:E466-E478
While modern genomic and proteomic technology enables rapid screening of novel proteins and peptides as potential drug candidates, design of delivery systems for these biologics remains challenging especially to achieve site-specific pharmacological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638bed52b7e79145febb05ee97b99fa8
https://doi.org/10.1208/aapsj080355
https://doi.org/10.1208/aapsj080355
Publikováno v:
International Journal of Cancer. 116:710-719
We previously exploited the frequent overexpression of folate receptors on cancer cells to decorate malignant cell surfaces selectively with folate-hapten conjugates. In antihapten-immunized hosts, this targeted localization of foreign haptens to tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a0a6fd924e02b16fd048fda69fcf28
https://doi.org/10.1002/ijc.21126
https://doi.org/10.1002/ijc.21126
Autor:
Antonia M.S. Müller, Everett Meyer, Jeanette Baker, Robert S. Negrin, Emanuela I. Sega, Mareike Florek, Dennis B. Leveson-Gower, Dominik Schneidawind
Publikováno v:
Blood. 124(11)
Acute graft-versus-host disease (GVHD) is induced by alloreactivity of donor T cells toward host antigens presented on antigen-presenting cells (APCs). Apoptotic cells are capable of inducing tolerance by altering APC maturation. Apoptosis can be ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42627ed2d93e447053745a0454e3c2f1
https://pubmed.ncbi.nlm.nih.gov/25214197
https://pubmed.ncbi.nlm.nih.gov/25214197
Autor:
Ho-Jin Shin, Jeanette Baker, Robert S. Negrin, Dennis B. Leveson-Gower, Aaron Smith, Emanuela I. Sega
Publikováno v:
Blood. 118(8)
Previous work has demonstrated that both rapamycin (RAPA) and IL-2 enhance CD4+CD25+Foxp3+ regulatory T-cell (Treg) proliferation and function in vitro. We investigated whether the combination of RAPA plus IL-2 could impact acute GVHD induction after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8671989ac1922af8da029273f80396
https://pubmed.ncbi.nlm.nih.gov/21734238
https://pubmed.ncbi.nlm.nih.gov/21734238
Autor:
Stephen J. Galli, Mareike Florek, R.S. Negrin, Janet Kalesnikoff, Dennis B. Leveson-Gower, Emanuela I. Sega
Publikováno v:
Biology of Blood and Marrow Transplantation. 17(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6761328db72ea6af29d7fde0feedc13
Publikováno v:
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 17
Naturally occurring regulatory T cells (Treg) are T cells with pivotal immunomodulatory capabilities. Treg cells express CD4, high levels of the IL-2 receptor CD25, and the Treg-specific transcription factor Foxp3, that was previously shown to be suf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3c69157433622a7b00990cff197381
https://pubmed.ncbi.nlm.nih.gov/21195311
https://pubmed.ncbi.nlm.nih.gov/21195311