Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Emanuela Gadaleta"'
Autor:
Lavanya Sivapalan, Graeme J. Thorn, Emanuela Gadaleta, Hemant M. Kocher, Helen Ross-Adams, Claude Chelala
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-17 (2022)
Abstract Background The utility of circulating tumour DNA (ctDNA) for longitudinal tumour monitoring in pancreatic ductal adenocarcinoma (PDAC) has not been explored beyond mutations in the KRAS proto-oncogene. Here, we aimed to characterise and trac
Externí odkaz:
https://doaj.org/article/f03d4864c59b41ca8e5c3d44dd567d9c
Autor:
Abbie E. Fearon, Edward P. Carter, Natasha S. Clayton, Edmund H. Wilkes, Ann-Marie Baker, Ekaterina Kapitonova, Bakhouche A. Bakhouche, Yasmine Tanner, Jun Wang, Emanuela Gadaleta, Claude Chelala, Kate M. Moore, John F. Marshall, Juliette Chupin, Peter Schmid, J. Louise Jones, Michelle Lockley, Pedro R. Cutillas, Richard P. Grose
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2469-2481 (2018)
Summary: Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to acquisition and maintenan
Externí odkaz:
https://doaj.org/article/7789669635aa4bc0b1737b37a1d0838a
Autor:
Daniel E Foxler, Katherine S Bridge, John G Foster, Paul Grevitt, Sean Curry, Kunal M Shah, Kathryn M Davidson, Ai Nagano, Emanuela Gadaleta, Hefin I Rhys, Paul T Kennedy, Miguel A Hermida, Ting‐Yu Chang, Peter E Shaw, Louise E Reynolds, Tristan R McKay, Hsei‐Wei Wang, Paulo S Ribeiro, Michael J Plevin, Dimitris Lagos, Nicholas R Lemoine, Prabhakar Rajan, Trevor A Graham, Claude Chelala, Kairbaan M Hodivala‐Dilke, Ian Spendlove, Tyson V Sharp
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 8, Pp n/a-n/a (2018)
Abstract The adaptive cellular response to low oxygen tensions is mediated by the hypoxia‐inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF‐α and HIF‐β subunits. Prolonged HIF expression is a key contri
Externí odkaz:
https://doaj.org/article/9b04680e29334b599d9575042b42aeeb
Autor:
Maryam Abdollahyan, Emanuela Gadaleta, Millahat Asif, Jorge Oscanoa, Rachel Barrow-McGee, Samantha Jones, Louise J Jones, Claude Chelala
Publikováno v:
Journal of Personalized Medicine
Volume 13
Issue 2
Pages: 360
Volume 13
Issue 2
Pages: 360
Longitudinal patient biospecimens and data advance breast cancer research through enabling precision medicine approaches for identifying risk, early diagnosis, improved disease management and targeted therapy. Cancer biobanks must evolve to provide n
Publikováno v:
The Journal of pathology. 257(4)
Breast cancer affects one in seven women worldwide during their lifetime. Widespread mammographic screening programs and education campaigns allow for early detection of the disease, often during its asymptomatic phase. Current practice in treatment
Autor:
Lavanya Sivapalan, Emanuela Gadaleta, Jorge Oscanoa, Nicholas R. Lemoine, Claude Chelala, Abu Z. Dayem Ullah
Publikováno v:
Nucleic Acids Research
SNPnexus is a web-based annotation tool for the analysis and interpretation of both known and novel sequencing variations. Since its last release, SNPnexus has received continual updates to expand the range and depth of annotations provided. SNPnexus
Autor:
Lavanya Sivapalan, Emanuela Gadaleta, Helen Ross-Adams, Claude Chelala, Hemant M. Kocher, Graeme J. Thorn
Publikováno v:
BMC cancer. 22(1)
Background The utility of circulating tumour DNA (ctDNA) for longitudinal tumour monitoring in pancreatic ductal adenocarcinoma (PDAC) has not been explored beyond mutations in the KRAS proto-oncogene. Here, we aimed to characterise and track patient
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Scientific Reports
Scientific Reports
High-throughput technologies have produced a large amount of experimental and biomedical data creating an urgent need for comprehensive and automated mining approaches. To meet this need, we developed SMAC (SMart Automatic Classification method): a t
Autor:
Ai Nagano, Michael D. Allen, N Allen, J Gomm, Louise J. Jones, M Thorat, Claude Chelala, Jack Cuzick, Emanuela Gadaleta, K. Ahmed, Rachel L. Nelan
Publikováno v:
Cancer Research. 79:P5-18
Background A review of breast screening highlighted the need to reduce overdiagnosis. Ductal Carcinoma In-Situ (DCIS) contributes significantly to this overdiagnosis. Epithelial cells in DCIS are as genetically advanced as those in invasive disease,
The Transcriptomic Landscape of Prostate Cancer Development and Progression: An Integrative Analysis
Autor:
Claude Chelala, Stefano Pirrò, Daniel M. Berney, Emanuela Gadaleta, Sakunthala C. Kudahetti, Yanan Zhu, Guoping Ren, Yong-Jie Lu, Xueying Mao, Bernard V. North, Jun Wang, Jacek Marzec, Luis Beltran, Elzbieta Stankiewicz, Amar Ahmad, Solene-Florence Kammerer-Jacquet, Helen Ross-Adams
Publikováno v:
Cancers
Cancers, Vol 13, Iss 345, p 345 (2021)
Volume 13
Issue 2
Cancers, Vol 13, Iss 345, p 345 (2021)
Volume 13
Issue 2
Simple Summary There is a tremendous amount of gene expression information available for prostate cancer, but very few tools exist to combine the disparate datasets generated across sample types and technical platforms. We present a method of integra