Effects of Physiological and Pathological Urea Concentrations on Human Microvascular Endothelial Cells

Autor: Graziano Colombo, Alessandra Altomare, Emanuela Astori, Lucia Landoni, Maria Lisa Garavaglia, Ranieri Rossi, Daniela Giustarini, Maria Chiara Lionetti, Nicoletta Gagliano, Aldo Milzani, Isabella Dalle-Donne

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 1, p 691 (2022)

Urea is the uremic toxin accumulating with the highest concentration in the plasma of chronic kidney disease (CKD) patients, not being completely cleared by dialysis. Urea accumulation is reported to exert direct and indirect side effects on the gast

Externí odkaz: https://doaj.org/article/52291e04120e4c3bbfe4d5d3877de6d2

In vitro copper oxide nanoparticle toxicity on intestinal barrier

Autor: Francesca Caloni, Emanuela Astori, Aharon Gedanken, M. Albonico, Nicholas Bellitto, Ilana Perelshtein, Paride Mantecca, Cristina Cortinovis, Elisa Moschini, Isabella Dalle-Donne, Maria Chiara Perego, Alessia Bertero, Graziano Colombo, V. Bassi

Publikováno v: Journal of Applied Toxicology. 41:291-302

The use of CuO nanoparticles (NPs) has increased greatly and their potential effects on human health need to be investigated. Differentiated Caco-2 cells were treated from the apical (Ap) and the basolateral (Bl) compartment with different concentrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b863c66da73ba1f40181dc11b4452957
https://doi.org/10.1002/jat.4047

Preliminary experience on the use of sucrosomial iron in hemodialysis: focus on safety, hemoglobin maintenance and oxidative stress

Autor: Claudio Angelini, Lucia Landoni, Isabella Dalle-Donne, Emanuela Astori, Graziano Colombo, Silvia Finazzi, Aldo Milzani, David Cucchiari, Francesco Reggiani

Publikováno v: International urology and nephrology. 54(5)

Iron is usually administered in hemodialysis patients by parenteral route, as oral absorption is poor due to high hepcidin levels. However, administrations of intravenous iron and iron overload are associated with high oxidative stress and systemic i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d128c5a625535d48e5abaf929fca6fe4
https://pubmed.ncbi.nlm.nih.gov/34510284

Cigarette smoke and glutathione: Focus on in vitro cell models

Autor: Maria Chiara Lionetti, Isabella Dalle-Donne, Daniela Giustarini, Ranieri Rossi, Maria Lisa Garavaglia, Emanuela Astori, Graziano Colombo, Caterina A. M. La Porta, Annalisa Santucci, Aldo Milzani

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 65

Cigarette smoke (CS) is one of the most important preventable risk factors for the development of respiratory diseases, cardiovascular diseases, stroke, and various types of cancer. Due to its high intracellular concentration and central role in main

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8b2bedd301eb5a0511423a7b9e26a5
https://pubmed.ncbi.nlm.nih.gov/32135238

Sulforaphane Cannot Protect Human Fibroblasts From Repeated, Short and Sublethal Treatments with Hydrogen Peroxide

Autor: Erica Soldati, Giulio Costantini, Maria Rita Fumagalli, Caterina A. M. La Porta, Emilio Ciusani, Emanuela Astori, Isabella Dalle-Donne, Graziano Colombo, Valentina Coccè, Maria Chiara Lionetti, Alessandro Miani, Federico Mutti, Aldo Milzani

Publikováno v: International Journal of Environmental Research and Public Health
Volume 16
Issue 4
International Journal of Environmental Research and Public Health, Vol 16, Iss 4, p 657 (2019)

A delicate balance of reactive oxygen species (ROS) exists inside the cell: when the mechanisms that control the level of ROS fail, the cell is in an oxidative stress state, a condition that can accelerate aging processes. To contrast the pro-aging e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207c7e68af96f7a3fb8cfbf3726f97fe
https://pubmed.ncbi.nlm.nih.gov/30813396