Elevated Serum Level of HMGB1 in Patients with the Antiphospholipid Syndrome

Autor: Valeria Manganelli, Antonella Capozzi, Simona Truglia, Cristiano Alessandri, Emanuela Lococo, Tina Garofalo, Caterina De Carolis, Fabrizio Conti, Guido Valesini, Maurizio Sorice, Agostina Longo, Roberta Misasi

Publikováno v: Journal of Immunology Research, Vol 2017 (2017)

Pregnancy problems are common in patients with rheumatic disease; indeed, autoimmune disorders and autoantibodies can affect pregnancy progress and lead to maternal complications. Recent studies have highlighted a close association between HMGB1, chr

Externí odkaz: https://doaj.org/article/2825079d131d447480182ba8eea2de72

The Mosaic of 'Seronegative' Antiphospholipid Syndrome

Autor: Fabrizio Conti, Antonella Capozzi, Simona Truglia, Emanuela Lococo, Agostina Longo, Roberta Misasi, Cristiano Alessandri, Guido Valesini, Maurizio Sorice

Publikováno v: Journal of Immunology Research, Vol 2014 (2014)

In the clinical practice it is possible to find patients with clinical signs suggestive of antiphospholipid syndrome (APS), who are persistently negative for the laboratory criteria of APS, that is, anti-cardiolipin antibodies (aCL), anti-β2-GPI ant

Externí odkaz: https://doaj.org/article/4e51e9faad2a4ffbafe36cbf68a172a5

SIRT1-SIRT3 Axis Regulates Cellular Response to Oxidative Stress and Etoposide

Autor: Matteo Antonio Russo, Lucia Polletta, Ilaria Carnevale, Eleonora Foglio, Serena Saladini, Laura Pellegrini, Patrizia D'Aquila, Dina Bellizzi, Luigi Sansone, Giuseppe Passarino, Enza Vernucci, Marco Tafani, Emanuela Lococo, Stefano Coppola, Massimo Fini

Publikováno v: Journal of Cellular Physiology. 232:1835-1844

Sirtuins are conserved NAD+ -dependent deacylases. SIRT1 is a nuclear and cytoplasmic sirtuin involved in the control of histones a transcription factors function. SIRT3 is a mitochondrial protein, which regulates mitochondrial function. Although, bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37b5b31499e1e706c27e889309926296
https://doi.org/10.1002/jcp.25711

Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies

Autor: Tina Garofalo, Roberta Misasi, Cristina Iannuccelli, Alessandra Nerviani, Manuela Di Franco, Michele Bombardieri, Guido Valesini, Emanuela Lococo, Maurizio Sorice, Valeria Manganelli, Cristiano Alessandri, Antonella Capozzi

Publikováno v: Rheumatology. 55:1374-1385

Objectives Autophagy may represent a functional processing event that creates a substrate for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since autophagy is a key cellular event involved in the generation of ci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227cffd1430ceea964d1ae662182125b
https://doi.org/10.1093/rheumatology/kew178

Graphene Oxide Nanoribbons Induce Autophagic Vacuoles in Neuroblastoma Cell Lines

Autor: Alessandra Zicari, Stefania Mardente, Federica Valentini, Emanuela Mari, Flavia Fico, Emanuela Morgante, Marco Tafani, Emanuela Lococo

Publikováno v: International Journal of Molecular Sciences; Volume 17; Issue 12; Pages: 1995
International Journal of Molecular Sciences, Vol 17, Iss 12, p 1995 (2016)
International Journal of Molecular Sciences

Since graphene nanoparticles are attracting increasing interest in relation to medical applications, it is important to understand their potential effects on humans. In the present study, we prepared graphene oxide (GO) nanoribbons by oxidative unzip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0955f23dd3bcd2a821cc1e6dcd89998