Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Emanuel Necas"'
Autor:
Kateřina Faltusová, Martin Báječný, Tomáš Heizer, Petr Páral, Chia-Ling Chen, Katarína Szikszai, Pavel Klener, Emanuel Nečas
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
In bone marrow transplantation (BMT), hematopoiesis-reconstituting cells are introduced following myeloablative treatment, which eradicates existing hematopoietic cells and disrupts stroma within the hematopoietic tissue. Both hematopoietic cells and
Externí odkaz:
https://doaj.org/article/b51d5061b3054bf6a21ac73645e44c81
Autor:
Kateřina Faltusová, Katarina Szikszai, Luděk Šefc, Filipp Savvulidi, Jana Linhartova, Martin Molik, Petr Paral, Emanuel Necas
Publikováno v:
Stem Cells. 36:1237-1248
Transgenic mice expressing green fluorescent protein (GFP) are useful in transplantation experiments. When we used ubiquitin-GFP (UBC-GFP) transgenic mice to study the availability of niches for transplanted hematopoietic stem and progenitor cells, t
Publikováno v:
Imaging and Tracking Stem Cells ISBN: 9781071606261
The thymidine analogues BrdU (5-bromo-2´-deoxyuridine) and EdU (5-ethynyl-2´-deoxyuridine) are routinely used for determination of the cells synthesizing DNA in the S-phase of the cell cycle. Availability of the anti-BrdU antibody clone MoBu-1 dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::076d4bb8c30d49a15a761008f7474df4
https://doi.org/10.1007/7651_2019_228
https://doi.org/10.1007/7651_2019_228
Hematopoietic stem and progenitor cells (HSPCs) are crucial for lifelong blood cell production. We analyzed the cell cycle and cell production rate in HSPCs in murine hematopoiesis. The labeling of DNA-synthesizing cells by two thymidine analogues, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e17ac81b5686d3d788bfd254f8fd04
https://europepmc.org/articles/PMC6291262/
https://europepmc.org/articles/PMC6291262/
Autor:
Petra Vockova, Emanuel Necas, Marek Trneny, Magdalena Klanova, Bokang Maswabi, Radek Jaksa, Dana Prukova, Jan Zivny, Lucie Lateckova, Vojtech Kulvait, Kyra Michalova, Jana Brezinova, Francisco J. Hernandez-Ilizaliturri, Tomáš Soukup, Martin Vokurka, Pavel Klener, Jan Molinsky
Publikováno v:
Laboratory Investigation. 94:806-817
Mantle cell lymphoma (MCL) is an aggressive type of B-cell non-Hodgkin lymphoma (NHL) associated with poor prognosis. Animal models of MCL are scarce. We established and characterized various in vivo models of metastatic human MCL by tail vein inject
Publikováno v:
ResearcherID
Scopus-Elsevier
Europe PubMed Central
Scopus-Elsevier
Europe PubMed Central
Matriptase-2, a membrane protein encoded by the Tmprss6 gene, is a negative regulator of hepcidin expression. Although matriptase-2 has been proposed to cleave membrane hemojuvelin, we have recently found decreased hemojuvelin protein levels in Tmprs
Publikováno v:
Biology of Blood and Marrow Transplantation. 19(5):713-719
Significant controversy exists regarding the impact of hematopoietic stroma damage by irradiation on the efficiency of engraftment of intravenously transplanted stem cells. It was previously demonstrated that in normal syngenic mice, all intravenousl
Autor:
Anna Jonasova, Krivjanska M, Marek Trneny, Monika Belickova, Emanuel Necas, Karina Vargova, Filipp Savvulidi, Nikola Curik, Hana Hájková, Petra Vlckova, Pospisil, Cedrik Haškovec, Pavel Burda, Tomas Stopka, Jaroslav Cermak, Peter Laslo
Publikováno v:
Leukemia. 26:1804-1811
Epigenetic 5-azacitidine (AZA) therapy of high-risk myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML) represents a promising, albeit not fully understood, approach. Hematopoietic transcription factor PU.1 is dynamically regulated b
Publikováno v:
Developmental & Comparative Immunology. 36:385-389
Adult B-lymphopoiesis is suppressed by the inhibitory effects of elevated estrogens during pregnancy. At the same time, hematopoietic cells in the fetal liver are resistant to this suppression by estrogens and ensure active production of B-cells. We
Autor:
Petr Paral, Tomáš Heizer, Chia-Ling Chen, Emanuel Necas, Martin Molik, Katerina Faltusova, Filipp Savvulidi
Publikováno v:
Experimental Hematology. 53:S117-S118