Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Emanuel Necas"'
Autor:
Kateřina Faltusová, Katarina Szikszai, Luděk Šefc, Filipp Savvulidi, Jana Linhartova, Martin Molik, Petr Paral, Emanuel Necas
Publikováno v:
Stem Cells. 36:1237-1248
Transgenic mice expressing green fluorescent protein (GFP) are useful in transplantation experiments. When we used ubiquitin-GFP (UBC-GFP) transgenic mice to study the availability of niches for transplanted hematopoietic stem and progenitor cells, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea991df19e53a03631c5fc906d10cd93
https://doi.org/10.1002/stem.2828
https://doi.org/10.1002/stem.2828
Publikováno v:
Imaging and Tracking Stem Cells ISBN: 9781071606261
The thymidine analogues BrdU (5-bromo-2´-deoxyuridine) and EdU (5-ethynyl-2´-deoxyuridine) are routinely used for determination of the cells synthesizing DNA in the S-phase of the cell cycle. Availability of the anti-BrdU antibody clone MoBu-1 dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::076d4bb8c30d49a15a761008f7474df4
https://doi.org/10.1007/7651_2019_228
https://doi.org/10.1007/7651_2019_228
Hematopoietic stem and progenitor cells (HSPCs) are crucial for lifelong blood cell production. We analyzed the cell cycle and cell production rate in HSPCs in murine hematopoiesis. The labeling of DNA-synthesizing cells by two thymidine analogues, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e17ac81b5686d3d788bfd254f8fd04
https://europepmc.org/articles/PMC6291262/
https://europepmc.org/articles/PMC6291262/
Autor:
Petra Vockova, Emanuel Necas, Marek Trneny, Magdalena Klanova, Bokang Maswabi, Radek Jaksa, Dana Prukova, Jan Zivny, Lucie Lateckova, Vojtech Kulvait, Kyra Michalova, Jana Brezinova, Francisco J. Hernandez-Ilizaliturri, Tomáš Soukup, Martin Vokurka, Pavel Klener, Jan Molinsky
Publikováno v:
Laboratory Investigation. 94:806-817
Mantle cell lymphoma (MCL) is an aggressive type of B-cell non-Hodgkin lymphoma (NHL) associated with poor prognosis. Animal models of MCL are scarce. We established and characterized various in vivo models of metastatic human MCL by tail vein inject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f82e6d11f7aea0fc7b248a3a9012120
https://doi.org/10.1038/labinvest.2014.61
https://doi.org/10.1038/labinvest.2014.61
Autor:
Anna Jonasova, Krivjanska M, Marek Trneny, Monika Belickova, Emanuel Necas, Karina Vargova, Filipp Savvulidi, Nikola Curik, Hana Hájková, Petra Vlckova, Pospisil, Cedrik Haškovec, Pavel Burda, Tomas Stopka, Jaroslav Cermak, Peter Laslo
Publikováno v:
Leukemia. 26:1804-1811
Epigenetic 5-azacitidine (AZA) therapy of high-risk myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML) represents a promising, albeit not fully understood, approach. Hematopoietic transcription factor PU.1 is dynamically regulated b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a4120dd903a2e840a338e0a33a3d8b
https://doi.org/10.1038/leu.2012.47
https://doi.org/10.1038/leu.2012.47
Publikováno v:
Developmental & Comparative Immunology. 36:385-389
Adult B-lymphopoiesis is suppressed by the inhibitory effects of elevated estrogens during pregnancy. At the same time, hematopoietic cells in the fetal liver are resistant to this suppression by estrogens and ensure active production of B-cells. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eeba106bfe7a3f29162fdd640b50d30
https://doi.org/10.1016/j.dci.2011.07.009
https://doi.org/10.1016/j.dci.2011.07.009
Autor:
Petr Paral, Tomáš Heizer, Chia-Ling Chen, Emanuel Necas, Martin Molik, Katerina Faltusova, Filipp Savvulidi
Publikováno v:
Experimental Hematology. 53:S117-S118
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9fc01b576b60f80f83b88679d0ff7a6
https://doi.org/10.1016/j.exphem.2017.06.294
https://doi.org/10.1016/j.exphem.2017.06.294
Autor:
Karin Vargova, Emanuel Necas, Jana Rybarova, Tomas Stopka, Juraj Kokavec, Vit Pospisil, Filipp Savvulidi, Anna Jonasova, Peter Laslo, Jiri Zavadil
Publikováno v:
The EMBO Journal. 30:4450-4464
The oncogenic cluster miR-17-92 encodes seven related microRNAs that regulate cell proliferation, apoptosis and development. Expression of miR-17-92 cluster is decreased upon cell differentiation. Here, we report a novel mechanism of the regulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c28a396e47cc63a39802c854c76d06c
https://doi.org/10.1038/emboj.2011.317
https://doi.org/10.1038/emboj.2011.317
Autor:
Emanuel Necas, Katarina Forgacova, Katerina Faltusova, Filipp Savvulidi, Jana Michalova, Ludek Sefc
Publikováno v:
Biology of Blood and Marrow Transplantation. 17(9):1273-1281
Hematopoietic stem and progenitor cells (HSPC) for bone marrow transplantation are currently obtained directly from living voluntary donors or from cord blood units. However, a suitable donor is not always found. Because HSPC are known for their rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14e860abd1d070ee90b502d55ea334e
Autor:
Petra Basova, Vojtech Kulvait, Šárka Pospíšilová, Josef Karban, Nikola Curik, Vit Pospisil, Emanuel Necas, Marek Mráz, Jiri Zavadil, Petra Obrtlikova, Tomas Stopka, Marek Trneny, Jiri Mayer, Karin Vargova, Filipp Savvulidi, Pavel Burda, Adela Berkova, Juraj Kokavec
Publikováno v:
Blood. 117:3816-3825
Elevated levels of microRNA miR-155 represent a candidate pathogenic factor in chronic B-lymphocytic leukemia (B-CLL). In this study, we present evidence that MYB (v-myb myeloblastosis viral oncogene homolog) is overexpressed in a subset of B-CLL pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee385809f644f38a3f4a798a23ec283
https://doi.org/10.1182/blood-2010-05-285064
https://doi.org/10.1182/blood-2010-05-285064