Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Emanuel Candeias"'
Autor:
João Duarte Magalhães, Emanuel Candeias, Inês Melo-Marques, António E. Abreu, Ana Raquel Pereira-Santos, Ana Raquel Esteves, Sandra Morais Cardoso, Nuno Empadinhas
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3423 (2024)
Parkinson’s disease (PD) is a progressive neurodegenerative disorder with an unknown cause. Recent research has highlighted the importance of the gut in neuronal and immune maturation through the exchange of nutrients and cellular signals. This has
Externí odkaz:
https://doaj.org/article/a36a0aea090b4d0096aed23b2ba9640a
Autor:
A. Raquel Esteves, Diana F. Silva, Diogo Banha, Emanuel Candeias, Beatriz Guedes, Sandra M. Cardoso
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102714- (2023)
Sporadic Parkinson's disease (sPD) is a complex multifactorial disorder which etiology remains elusive. Several mechanisms have been described to contribute to PD development namely mitochondrial dysfunction, activation of inflammatory pathways and t
Externí odkaz:
https://doaj.org/article/afa23a29705d44608f9f7c94050897eb
Autor:
João D. Magalhães, Ana Raquel Esteves, Emanuel Candeias, Diana F. Silva, Nuno Empadinhas, Sandra Morais Cardoso
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4339 (2023)
Mitochondria play a key role in regulating host metabolism, immunity and cellular homeostasis. Remarkably, these organelles are proposed to have evolved from an endosymbiotic association between an alphaproteobacterium and a primitive eukaryotic host
Externí odkaz:
https://doaj.org/article/cdba6efea9984eff87b052ec4637062f
Autor:
Diana F. Silva, Emanuel Candeias, A. Raquel Esteves, João D. Magalhães, I. Luísa Ferreira, Daniela Nunes-Costa, A. Cristina Rego, Nuno Empadinhas, Sandra M. Cardoso
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-18 (2020)
Abstract Background After decades of research recognizing it as a complex multifactorial disorder, sporadic Alzheimer’s disease (sAD) still has no known etiology. Adding to the myriad of different pathways involved, bacterial neurotoxins are assumi
Externí odkaz:
https://doaj.org/article/c5b25e1424564ea791b8b53e66fdf2e5
Autor:
Antónia Diniz, Marco G. Alves, Emanuel Candeias, Ana I. Duarte, Paula I. Moreira, Branca M. Silva, Pedro F. Oliveira, Luís Rato
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 8912 (2022)
Diabetes mellitus type 2 (T2DM) has been associated with alterations in the male reproductive tract, especially in the epididymis. Although it is known that T2DM alters epididymal physiology, disturbing mitochondrial function and favoring oxidative s
Externí odkaz:
https://doaj.org/article/f15a76d20eb543d9baf5e561ebf72fb4
Autor:
Luca Piemontese, Daniel Tomás, Asha Hiremathad, Vito Capriati, Emanuel Candeias, Sandra M. Cardoso, Sílvia Chaves, M. Amélia Santos
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1212-1224 (2018)
A new series of multifunctional hybrids, based on the structure of the donepezil (DNP) drug, have been developed and evaluated as potential anti Alzheimer’s disease (AD) agents. The rationale of this study was the conjugation of a benzylpiperidine/
Externí odkaz:
https://doaj.org/article/576dcbc606174caaba74b8e132d38b00
Autor:
Ana I. Duarte, Emanuel Candeias, Inês N. Alves, Débora Mena, Daniela F. Silva, Nuno J. Machado, Elisa J. Campos, Maria S. Santos, Catarina R. Oliveira, Paula I. Moreira
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1746 (2020)
Alzheimer’s disease (AD) is the most common form of dementia worldwide, being characterized by the deposition of senile plaques, neurofibrillary tangles (enriched in the amyloid beta (Aβ) peptide and hyperphosphorylated tau (p-tau), respectively)
Externí odkaz:
https://doaj.org/article/919a4addff9d4c4ca3558df746dc3ef1
Autor:
Rajeshwari Rajeshwari, Karam Chand, Emanuel Candeias, Sandra M. Cardoso, Sílvia Chaves, M. Amélia Santos
Publikováno v:
Molecules, Vol 24, Iss 3, p 587 (2019)
Research on neurodegenerative brain disorders, namely the age-dependent Alzheimer’s disease (AD), has been intensified in the last decade due to the absence of a cure and the recognized increasing of life expectancy for populations. To address the
Externí odkaz:
https://doaj.org/article/ab10c78bc0154f96b152fc4f369db662
Autor:
Hans Pettersson, Cesare Patrone, Thomas Nyström, Vladimer Darsalia, Stefania Ceruti, Ana I. Duarte, Jan Kehr, Takashi Yoshitake, Maria P. Abbracchio, Emanuel Candeias, Grazyna Lietzau, Josefin Skogsberg, Thomas Klein, Giulia Magni
Publikováno v:
Neurobiology of Aging. 89:12-23
The nigrostriatal dopaminergic system (NDS) controls motor activity, and its impairment during type 2 diabetes (T2D) progression could increase Parkinson's disease risk in diabetics. If so, whether glycemia regulation prevents this impairment needs t
Autor:
A. Raquel Esteves, Susana Alarico, I. Luísa Ferreira, Mario F. Munoz-Pinto, Emanuel Candeias, Nuno Empadinhas, Sandra M. Cardoso, Diana Silva, Igor Tiago, João D. Magalhães, A. Raquel Pereira-Santos, Daniela Nunes-Costa
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ObjectiveIdiopathic Parkinson’s disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote c