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A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury

Autor: Kost-Alimova, Maria, Sidhom, Eriene-Heidi, Satyam, Abhigyan, Chamberlain, Brian T., Dvela-Levitt, Moran, Melanson, Michelle, Alper, Seth L., Santos, Jean, Gutierrez, Juan, Subramanian, Ayshwarya, Byrne, Patrick J., Grinkevich, Elizabeth, Reyes-Bricio, Estefanía, Kim, Choah, Clark, Abbe R., Watts, Andrew J.B., Thompson, Rebecca, Marshall, Jamie, Pablo, Juan Lorenzo, Coraor, Juliana, Roignot, Julie, Vernon, Katherine A., Keller, Keith, Campbell, Alissa, Emani, Maheswarareddy, Racette, Matthew, Bazua-Valenti, Silvana, Padovano, Valeria, Weins, Astrid, McAdoo, Stephen P., Tam, Frederick W.K., Ronco, Luciene, Wagner, Florence, Tsokos, George C., Shaw, Jillian L., Greka, Anna

Publikováno v: In Cell Reports Medicine 17 November 2020 1(8)

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A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic.

Autor: Alimova M; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Sidhom EH; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Satyam A; Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA., Dvela-Levitt M; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Melanson M; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Chamberlain BT; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Alper SL; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA., Santos J; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Gutierrez J; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Subramanian A; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Grinkevich E; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Bricio ER; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Kim C; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Clark A; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Watts A; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Thompson R; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Marshall J; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Pablo JL; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Coraor J; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Roignot J; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Vernon KA; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Keller K; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Campbell A; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Emani M; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Racette M; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Bazua-Valenti S; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Padovano V; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Weins A; Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., McAdoo SP; Department of Immunology and Inflammation, Imperial College, Hammersmith Hospital, London, UK., Tam FWK; Department of Immunology and Inflammation, Imperial College, Hammersmith Hospital, London, UK., Ronco L; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Wagner F; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Tsokos GC; Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA., Shaw JL; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Greka A; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2020 Jun 30. Date of Electronic Publication: 2020 Jun 30.