Zobrazeno 1 - 10 of 95 pro vyhledávání: '"Eman S, Nossier"'
1
Akademický článek
Novel quinazolin-4-one based derivatives bearing 1,2,3-triazole and glycoside moieties as potential cytotoxic agents through dual EGFR and VEGFR-2 inhibitory activity
Autor: Adel A.-H. Abdel-Rahman, Mohamed N. El-Bayaa, Asmaa Sobhy, Eman M. El-Ganzoury, Eman S. Nossier, Hanem M. Awad, Wael A. El-Sayed
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract The toxicity that was caused by the developed medications for anticancer treatment is, unfortunately, an earnest problem stemming from the various involved targets, and accordingly, intense research for overcoming such a phenomenon remains i
Externí odkaz: https://doaj.org/article/a6944b4d1bae441fbf616c45650e891e
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2
Akademický článek
New sulfonamide-based glycosides incorporated 1,2,3-triazole as cytotoxic agents through VEGFR-2 and carbonic anhydrase inhibitory activity
Autor: Hebat-Allah S. Abbas, Eman S. Nossier, May A. El-Manawaty, Mohamed N. El-Bayaa
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract New sulfonamide-triazole-glycoside hybrids derivatives were designed, synthesised, and investigated for anticancer efficacy. The target glycosides’ cytotoxic activity was studied with a panel of human cancer cell lines. Sulfonamide-based d
Externí odkaz: https://doaj.org/article/9f9aa7da5488460884a5e4f278bf027c
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4
Akademický článek
Design, synthesis, and anti-cancer evaluation of new pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as potential EGFRWT and EGFRT790M inhibitors and apoptosis inducers
Autor: Heba S. A. Elzahabi, Eman S. Nossier, Rania A. Alasfoury, May El-Manawaty, Sara M. Sayed, Eslam B. Elkaeed, Ahmed M. Metwaly, Mohamed Hagras, Ibrahim H. Eissa
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1053-1076 (2022)
A new series of pyrido[2,3-d]pyrimidin-4(3H)-one derivatives having the essential pharmacophoric features of EGFR inhibitors has been designed and synthesised. Cell viability screening was performed for these compounds against A-549, PC-3, HCT-116, a
Externí odkaz: https://doaj.org/article/043a1c62528a44f39d1f4e0955ba4c9b
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5
Akademický článek
Designing Potent Anti-Cancer Agents: Synthesis and Molecular Docking Studies of Thieno[2,3-d][1,2,4]triazolo[1,5-a]pyrimidine Derivatives
Autor: Eman S. M. Elsenbawy, Zafer S. Alshehri, Nouf A. Babteen, Adel A.-H. Abdel-Rahman, Mai A. El-Manawaty, Eman S. Nossier, Reem K. Arafa, Nasser A. Hassan
Publikováno v: Molecules, Vol 29, Iss 5, p 1067 (2024)
A new series of thieno[2,3-d][1,2,4]triazolo[1,5-a]pyrimidines was designed and synthesized using readily available starting materials, specifically, β-enaminoester. Their cytotoxicity was screened against three cancer cell lines, namely, MCF-7, HCT
Externí odkaz: https://doaj.org/article/8069d6666fc644e69bf87183e923e79a
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7
Akademický článek
Nanoparticles of a Pyrazolo-Pyridazine Derivative as Potential EGFR and CDK-2 Inhibitors: Design, Structure Determination, Anticancer Evaluation and In Silico Studies
Autor: Heba E. Hashem, Abd El-Galil E. Amr, Abdulrahman A. Almehizia, Ahmed M. Naglah, Benson M. Kariuki, Heba A. Eassa, Eman S. Nossier
Publikováno v: Molecules, Vol 28, Iss 21, p 7252 (2023)
The strategic planning of this study is based upon using the nanoformulation method to prepare nanoparticles 4-SLNs and 4-LPHNPs of the previously prepared 4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine (4) after confirming its structure with singl
Externí odkaz: https://doaj.org/article/1737292098e947cc901c6e1b9e251cc0
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9
Akademický článek
Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR
Autor: Reham R. Khattab, Asma K. Alshamari, Allam A. Hassan, Hussein H. Elganzory, Wael A. El-Sayed, Hanem M. Awad, Eman S. Nossier, Nasser A. Hassan
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 504-516 (2021)
In the current study, new thienopyrimidine conjugates bearing 1,2,3-triazole core and different sugar moieties have been designed and synthesized by Cu(I)-catalysed click dipolar cycloaddition. The cytotoxic activity of the synthesised conjugates 2,
Externí odkaz: https://doaj.org/article/4220b9217cba473785711b9e789c32b7
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10
Akademický článek
Novel heterocyclic hybrids of pyrazole targeting dihydrofolate reductase: design, biological evaluation and in silico studies
Autor: Ismail M. M. Othman, Mohamed A. M. Gad-Elkareem, Abd El-Galil E. Amr, Mohamed A. Al-Omar, Eman S. Nossier, Elsayed A. Elsayed
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1491-1502 (2020)
A novel series of pyrazole analogues including hydrazones, pyrazolo[4,3-c]-pyridazines, pyrazolo[3,4-e][1,2,4]triazine and pyrazolo[3,4-d][1,2,3]triazoles was designed, synthesised and screened for their in vitro antimicrobial and DHFR inhibition act
Externí odkaz: https://doaj.org/article/f5ae74eb141040d29bad368f33573625
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