Design and synthesis of novel quinazolinone-based derivatives as EGFR inhibitors with antitumor activity

Autor: Amr Sonousi, Rasha A. Hassan, Eman O. Osman, Amr M. Abdou, Soha H. Emam

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2644-2659 (2022)

Nineteen new quinazolin-4(3H)-one derivatives 3a–g and 6a–l were designed and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds was tested in vitro against 60 different human cell lines. The most potent comp

Externí odkaz: https://doaj.org/article/e43d0eca47954f19a7dcf20e80e8a8de

Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR‐2 and DNA gyrase inhibition, and in silico studies

Autor: Soha H. Emam, Rasha A. Hassan, Eman O. Osman, Mohammed I. A. Hamed, Amr M. Abdou, Mai M. Kandil, Eman Maher Elbaz, Demiana S. Mikhail

Publikováno v: Drug Development Research. 84:475-499

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c5f0ff48f137b7e20eb89a4c05e4abb
https://doi.org/10.1002/ddr.22037

Synthesis and biological evaluation of halogenated phenoxychalcones and their corresponding pyrazolines as cytotoxic agents in human breast cancer

Autor: Peter A. Halim, Rasha A. Hassan, Khaled O. Mohamed, Soha O. Hassanin, Mona G. Khalil, Amr M. Abdou, Eman O. Osman

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 189-201 (2022)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record

Novel halogenated phenoxychalcones 2a���f and their corresponding N-acetylpyrazolines 3a���f were synthesised and evaluated for their anticancer activities against breast cancer cell line (MCF-7) and normal breast cell line (MCF-10a), com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30703d3dfc8f1399a6ed21b7c84b0fd
https://doi.org/10.1080/14756366.2021.1998023

Electrochemical synthesis of tetrahydrobenzo[b]pyran derivatives in deep eutectic solvents

Autor: Eman O. Osman, Amr M. Mahmoud, Sally S. El-Mosallamy, Hala B. El-Nassan

Publikováno v: Journal of Electroanalytical Chemistry. 920:116629

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90c8b1e8232a5795982845ee72cef8a4
https://doi.org/10.1016/j.jelechem.2022.116629