Výsledky vyhledávání - "Eman M Zaghloul"

Akademický článek

Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency

Autor: Helena Sork, Joel Z Nordin, Janne J Turunen, Oscar PB Wiklander, Burcu Bestas, Eman M Zaghloul, Helerin Margus, Kärt Padari, Adil D Duru, Giulia Corso, Jeremy Bost, Pieter Vader, Margus Pooga, CI Edvard Smith, Matthew JA Wood, Raymond M Schiffelers, Mattias Hällbrink, Samir EL Andaloussi

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)

The advantages of lipid-based transfection reagents have permitted their widespread use in molecular biology and gene therapy. This study outlines the effect of cryo-manipulation of a cationic lipid-based formulation, Lipofectamine 2000, which, after

Externí odkaz: https://doaj.org/article/48a6da84132a4f1db17f5fc1b93f1a61

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Akademický článek

Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo

Autor: Safa Bazaz, Tõnis Lehto, Rahel Tops, Olof Gissberg, Dhanu Gupta, Burcu Bestas, Jeremy Bost, Oscar P. B. Wiklander, Helena Sork, Eman M. Zaghloul, Doste R. Mamand, Mattias Hällbrink, Rannar Sillard, Osama Saher, Kariem Ezzat, C. I. Edvard Smith, Samir EL Andaloussi, Taavi Lehto

Publikováno v: Biomedicines, Vol 9, Iss 8, p 1046 (2021)

Splice-switching therapy with splice-switching oligonucleotides (SSOs) has recently proven to be a clinically applicable strategy for the treatment of several mis-splice disorders. Despite this, wider application of SSOs is severely limited by the in

Externí odkaz: https://doaj.org/article/299480288c2b4df49f3d5ab7d99ca7c2

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Oligonucleotides Targeting DNA Repeats Downregulate

Autor: Tea, Umek, Thomas, Olsson, Olof, Gissberg, Osama, Saher, Eman M, Zaghloul, Karin E, Lundin, Jesper, Wengel, Eric, Hanse, Henrik, Zetterberg, Dzeneta, Vizlin-Hodzic, C I Edvard, Smith, Rula, Zain

Publikováno v: Nucleic Acid Therapeutics

Huntington's disease (HD) is one of the most common, dominantly inherited neurodegenerative disorders. It affects the striatum, cerebral cortex, and other subcortical structures leading to involuntary movement abnormalities, emotional disturbances, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d43b5ec540d370eff1d232a171365ef3
https://pubmed.ncbi.nlm.nih.gov/34520257

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Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo

Autor: Jeremy P Bost, Eman M. Zaghloul, Samir El Andaloussi, Rannar Sillard, Tõnis Lehto, C. I. Edvard Smith, Kariem Ezzat, Olof Gissberg, Safa Bazaz, Taavi Lehto, Osama Saher, Rahel Tops, Doste R. Mamand, Mattias Hällbrink, Burcu Bestas, Oscar P. B. Wiklander, Dhanu Gupta, Helena Sork

Publikováno v: Biomedicines
Volume 9
Issue 8
Biomedicines, Vol 9, Iss 1046, p 1046 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0d60c67589cc5e0726d3afec061b42

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Delivery, Effect on Cell Viability, and Plasticity of Modified Aptamer Constructs

Autor: Corinne Landras-Guetta, C. I. Edvard Smith, Eman M. Zaghloul, Jesper Wengel, Karin E. Lundin, Rula Zain, Olof Gissberg, Chi-Hung Nguyen

Publikováno v: Gissberg, O, Zaghloul, E M, Lundin, K E, Nguyen, C-H, Landras-Guetta, C, Wengel, J, Zain, R & Smith, C I E 2016, ' Delivery, Effect on Cell Viability, and Plasticity of Modified Aptamer Constructs ', Nucleic Acid Therapeutics, vol. 26, no. 3, pp. 183-189 . https://doi.org/10.1089/nat.2015.0592

AS1411 is a g-quadruplex-forming aptamer capable of selectively entering cancer cells by nucleolin receptor-mediated uptake. In this study, we investigated the cell internalization properties and plasticity of AS1411 carrying different locked nucleic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7168d7e5b3c163bc4fccb12b804a77c1
https://doi.org/10.1089/nat.2015.0592

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Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides

Autor: Amer F. Saleh, Ülo Langel, Mattias Hällbrink, Michael J. Gait, Graham McClorey, Samir El Andaloussi, Suzan M. Hammond, Matthew J.A. Wood, C. I. Edvard Smith, Peter Järver, Andrey A. Arzumanov, Eman M. Zaghloul

Publikováno v: Nucleic Acid Therapeutics

Oligonucleotide analogs have provided novel therapeutics targeting various disorders. However, their poor cellular uptake remains a major obstacle for their clinical development. Negatively charged oligonucleotides, such as 2′-O-Methyl RNA and lock

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b4fb2758b64af6424147955c879861
https://doi.org/10.1089/nat.2014.0511

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Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA

Autor: Y. Vladimir Pabon, Burcu Bestas, Sylvain Geny, Samir El Andaloussi, Rula Zain, C. I. Edvard Smith, Per T. Jørgensen, Jesper Wengel, Eman M. Zaghloul, Cristina S. J. Rocha, Helen Bergquist, Iulian I. Oprea, Erik B. Pedersen, Pedro Moreno, Karin E. Lundin

Publikováno v: Moreno, P M D, Geny, S, Pabon, Y V, Bergquist, H, Zaghloul, E M, Rocha, C S J, Oprea, I I, Bestas, B, Andaloussi, S E, Jørgensen, P T, Pedersen, E B, Lundin, K E, Zain, R, Wengel, J & Smith, C I E 2013, ' Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA ', Nucleic Acids Research, vol. 41, no. 5, pp. 3257-3273 . https://doi.org/10.1093/nar/gkt007
Nucleic Acids Research
Nucleic Acids Research; Vol 41

In spite of the many developments in synthetic oligonucleotide (ON) chemistry and design, invasion into double-stranded DNA (DSI) under physiological salt and pH conditions remains a challenge. In this work, we provide a new ON tool based on locked n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33c536d31a11df21278a74d1e527aa4
https://doi.org/10.1093/nar/gkt007

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PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation

Autor: Matthew J.A. Wood, Ülo Langel, Staffan Lindberg, Samir El Andaloussi, Mattias Hällbrink, Michael J. Gait, Suzan M. Hammond, Tarek Magdy, Joana R Viola, Taavi Lehto, Rania Abdo, Kariem Ezzat, Pedro Moreno, Rannar Sillard, C. I. Edvard Smith, Peter Guterstam, Andrey A. Arzumanov, Eman M. Zaghloul

Publikováno v: Nucleic Acids Research

Numerous human genetic diseases are caused by mutations that give rise to aberrant alternative splicing. Recently, several of these debilitating disorders have been shown to be amenable for splice-correcting oligonucleotides (SCOs) that modify splici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0680b621f39bc99b5a08460440d0c51b
https://doi.org/10.1093/nar/gkr072

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Solid formulation of cell-penetrating peptide nanocomplexes with siRNA and their stability in simulated gastric conditions

Autor: Samir El Andaloussi, Tarek Magdy, Kariem Ezzat, Ramy El-Sayed, Taavi Lehto, C. I. Edvard Smith, Ülo Langel, Eman M. Zaghloul

Publikováno v: Journal of Controlled Release

Cell-penetrating peptides (CPPs) are short cationic peptides that have been extensively studied as drug delivery vehicles for proteins, nucleic acids and nanoparticles. However, the formulation of CPP-based therapeutics into different pharmaceutical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b00578504134a785a309b717587457b
https://ora.ox.ac.uk/objects/uuid:2ade086b-dc53-4a43-aa76-bc3d3621e071

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Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes

Autor: Patrick J. Hrdlicka, Tomasz Krzywkowski, Jesper Wengel, Mats Nilsson, Chenguang Lou, Per T. Jørgensen, Karin E. Lundin, Sylvain Geny, Rula Zain, Abdirisaq J. Isse, Pedro Moreno, Nicolai K. Andersen, Amro M. El-Madani, Eman M. Zaghloul, Y. Vladimir Pabon, Erik B. Pedersen, Brooke A. Anderson, C. I. Edvard Smith, Olof Gissberg

Publikováno v: Geny, S, Moreno, P M D, Krzywkowski, T, Gissberg, O, Andersen, N K, Isse, A J, El-Madani, A M, Lou, C, Pabon, Y V, Anderson, B A, Zaghloul, E M, Zain, R, Hrdlicka, P J, Jørgensen, P T, Nilsson, M, Lundin, K E, Pedersen, E B, Wengel, J & Smith, C I E 2016, ' Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes ', Nucleic Acids Research, vol. 44, no. 5, pp. 2007-2019 . https://doi.org/10.1093/nar/gkw021
Nucleic Acids Research

Targeting and invading double-stranded DNA with synthetic oligonucleotides under physiological conditions remain a challenge. Bis-locked nucleic acids (bisLNAs) are clamp-forming oligonucleotides able to invade into supercoiled DNA via combined Hoogs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a02dd63cd74049655d3b2a48a35844
https://findresearcher.sdu.dk:8443/ws/files/119274236/Nucl._Acids_Res._2016_Geny_2007_19.pdf

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