Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Eman K. A. Abdelall"'
Publikováno v:
BMC Chemistry, Vol 14, Iss 1, Pp 1-15 (2020)
Abstract Three series of 2-(4-methylsulfonylphenyl) indole derivatives have been designed and synthesized. The synthesized compounds were assessed for their antimicrobial, COX inhibitory and anti-inflammatory activities. Compound 7g was identified to
Externí odkaz:
https://doaj.org/article/e0dd975b703f4901a10ae457da224b90
Autor:
Eman K. A. Abdelall, John N. Philoppes
Publikováno v:
ARKIVOC, Vol 2016, Iss 5, Pp 210-224 (2016)
Externí odkaz:
https://doaj.org/article/5c8125027c8b41b0a009711674dd20d6
Autor:
Khaled R. A. Abdellatif, Eman K. A. Abdelall, Mohamed A. Abdelgawad, Rasha R. Ahmed, Rania B. Bakr
Publikováno v:
Molecules, Vol 19, Iss 3, Pp 3297-3309 (2014)
3,6-Dimethyl-1-phenyl-1H-pyrazolo[3,4-d][1,3]oxazin-4-one (3) was prepared by hydrolysis of ethyl 5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carboxylate (1) to afford the corresponding carboxylic acid 2, which was reacted with acetic anhydride to give 3
Externí odkaz:
https://doaj.org/article/79ab0af34f04423489bdc06b3cde8a1f
Autor:
Eman K. A. Abdelall, Mohamed A. S. Badawy, El-Shaymaa El-Nahass, Hamdy M. Abdel-Rahman, Khaled R.A. Abdellatif
Publikováno v:
RSC Advances. 11:27659-27673
A novel series of benzimidazole derivatives wherein 4-(methylsulfonyl) phenyl pharmacophore attached via its C-2 position was designed and synthesized. These compounds were evaluated in vitro as cyclooxygenase-1(COX-1)/cyclooxygenese-2(COX-2) inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa638d887429d4f756dc0637a4b0ccbc
https://doi.org/10.1039/d1ra04756f
https://doi.org/10.1039/d1ra04756f
Publikováno v:
Bioorganic Chemistry. 86:235-253
Four pyrazolopyrimidine series were prepared with a substitution at position- 4 by Schiff base, triazole, oxadiazole and pyrazole moieties (7a-f, 8a,b, 9a-f, 10a,b and 13a,b), respectively. All the synthesized compounds were evaluated in vitro agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fce431b1b25a7bc90d233766a90df9
https://doi.org/10.1016/j.bioorg.2019.01.031
https://doi.org/10.1016/j.bioorg.2019.01.031
Autor:
Mohamed A S, Badawy, Eman K A, Abdelall, El-Shaymaa, El-Nahass, Khaled R A, Abdellatif, Hamdy M, Abdel-Rahman
Publikováno v:
RSC advances. 11(44)
A novel series of benzimidazole derivatives wherein 4-(methylsulfonyl) phenyl pharmacophore attached
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8489de83da8b7129a70a703a739a72dd
https://pubmed.ncbi.nlm.nih.gov/35480694
https://pubmed.ncbi.nlm.nih.gov/35480694
Autor:
Maha M. Abdel-Fattah, Yasmin Y. M. Abdelgawad, Khaled R.A. Abdellatif, El-Shaymaa El-Nahass, Heba A.H. Elshemy, Eman K. A. Abdelall
Publikováno v:
Archiv der PharmazieREFERENCES. 354(4)
New indomethacin analogs 4a-g, 5, 6, 8a, and 8b were synthesized to overcome the nonselectivity and ulcer liability of indomethacin. All newly synthesized compounds were more potent against cyclooxygenase 2 (COX-2; IC50 value range: 0.09-0.4 μМ) as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd193bfbd04fbfba184a51f648168b6d
https://pubmed.ncbi.nlm.nih.gov/33314237
https://pubmed.ncbi.nlm.nih.gov/33314237
Three series of 2-(4-methylsulfonylphenyl) indole derivatives have been designed and synthesized. The synthesized compounds were evaluated for their antimicrobial, COX inhibitory and anti-inflammatory activities. Compound 7g was identified to be the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49dc0f34b266fef21438e0cef327cc6d
https://doi.org/10.21203/rs.2.17036/v4
https://doi.org/10.21203/rs.2.17036/v4
Autor:
Khaled R A, Abdellatif, Eman K A, Abdelall, Heba A H, Elshemy, John N, Philoppes, Emad H M, Hassanein, Nesma M, Kahk
Publikováno v:
Bioorganic Chemistry. 120:105627
Four new series of 1,2,4 triazole derivatives 4a,b 5a-d, 6a-f, and 7a,b possessing methylsulphonylphenyl moiety as COX-2 pharmacophore were designed and synthesized. The target compounds were prepared and evaluated in-vitro against COX-1 and COX-2 en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99ed12e8d00dbc63926aebbb6f96c55
https://doi.org/10.1016/j.bioorg.2022.105627
https://doi.org/10.1016/j.bioorg.2022.105627
Autor:
Eman K. A. Abdelall, Phoebe F. Lamie, El-Shaymaa El-Nahaas, Khaled R.A. Abdellatif, Dina M. E. Amin, Heba A.H. Elshemy
Publikováno v:
Journal of Molecular Structure. 1240:130554
Novel anti-inflammatory pyrazole derivatives (4a,b, 5a,b, 6a,b, 7a,b, 8a,b, 11a-c, 12a-c, 13a-c and 14a-c) were designed as coxib analogues, synthesized and evaluated for both in vitro and in vivo inhibitory activity. Compounds 4a, 4b, 5a, 6a, 6b, 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::415818707cf5c08f429e4767fbd566e7
https://doi.org/10.1016/j.molstruc.2021.130554
https://doi.org/10.1016/j.molstruc.2021.130554