Protective Efficacy of Anti-Hyr1p Monoclonal Antibody against Systemic Candidiasis Due to Multi-Drug-Resistant Candida auris

Autor: Shakti Singh, Ashley Barbarino, Eman G. Youssef, Declan Coleman, Teclegiorgis Gebremariam, Ashraf S. Ibrahim

Publikováno v: Journal of Fungi, Vol 9, Iss 1, p 103 (2023)

Candida auris is a multi-drug-resistant fungal pathogen that can survive outside the host and can easily spread and colonize the healthcare environment, medical devices, and human skin. C. auris causes serious life-threatening infections (up to 60% m

Externí odkaz: https://doaj.org/article/6a8a6468c9b941fbb3f80fc0670535ac

Calli Essential Oils Synergize with Lawsone against Multidrug Resistant Pathogens

Autor: Sameh S. M. Soliman, Abrar I. Alsaadi, Eman G. Youssef, Gregory Khitrov, Ayman M. Noreddin, Mohamed I. Husseiny, Ashraf S. Ibrahim

Publikováno v: Molecules, Vol 22, Iss 12, p 2223 (2017)

The fast development of multi-drug resistant (MDR) organisms increasingly threatens global health and well-being. Plant natural products have been known for centuries as alternative medicines that can possess pharmacological characteristics, includin

Externí odkaz: https://doaj.org/article/8dfa0f415ff049e8bde36d7b39c9087f

Mucoricin is a Ricin-Like Toxin that is Critical for the Pathogenesis of Mucormycosis

Autor: Ellen S. Vitetta, Teclegiorgis Gebremariam, Shakti Singh, Sondus Alkhazraji, Vivek Venkataramani, Marc Swidergall, Ashraf S. Ibrahim, Abigail Rich, Julie C. Dunning Hotopp, Yiyou Gu, Georgios Chamilos, Eman G. Youssef, Nicolas J. Mantis, Clara Baldin, Antonis Pikoulas, Abdullah Alqarihi, Vincent M. Bruno, Scott G. Filler, Christina Perske, John E. Edwards, Sameh S. M. Soliman

Publikováno v: Nature microbiology, vol 6, iss 3
Nature microbiology

Fungi of the order Mucorales cause mucormycosis, a lethal infection with an incompletely understood pathogenesis. We demonstrate that Mucorales fungi produce a toxin, which plays a central role in virulence. Polyclonal antibodies against this toxin i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0cd4c9e4b7662666fd48fa18a672a01
https://doi.org/10.1101/2021.01.13.426274

Preserving Vascular Integrity Protects Mice Against Multidrug-Resistant Gram-Negative Bacterial Infection

Autor: Teclegiorgis Gebremariam, Sondus Alkhazraji, Samuel W. French, Erik Kish-Trier, Dean Y. Li, Eman G. Youssef, Ashraf S. Ibrahim, Weiquan Zhu, Shannon J. Odelberg, Bianca Rich, Alan L. Mueller, Yiyou Gu, Zongzhong Tong, Lina Zhang, Claudia V. Araujo

The rise in multidrug resistant (MDR) organisms portends a serious global threat to the healthcare system with nearly untreatable infectious diseases, including pneumonia and its often fatal sequelae, acute respiratory distress syndrome (ARDS) and se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf8efeda3e15f1cb69d43ff4d17ca38

The Hyr1 protein from the fungus Candida albicans is a cross kingdom immunotherapeutic target for Acinetobacter bacterial infection

Autor: Marc Swidergall, Belal A. Ibrahim, Ashraf S. Ibrahim, Guanpingsheng Luo, Sondus Alkhazraji, John E. Edwards, Priya Uppuluri, Scott G. Filler, Michael Bolaris, Michael R. Yeaman, Lin Lin, Eman G. Youssef, Nannette Y. Yount, Abdullah Alqarihi

Publikováno v: PLoS Pathogens
PLoS pathogens, vol 14, iss 5
PLoS Pathogens, Vol 14, Iss 5, p e1007056 (2018)
Uppuluri, P; Lin, L; Alqarihi, A; Luo, G; Youssef, EG; Alkhazraji, S; et al.(2018). The Hyr1 protein from the fungus Candida albicans is a cross kingdom immunotherapeutic target for Acinetobacter bacterial infection. PLoS Pathogens, 14(5). doi: 10.1371/journal.ppat.1007056. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9vn697sq

Different pathogens share similar medical settings and rely on similar virulence strategies to cause infections. We have previously applied 3-D computational modeling and bioinformatics to discover novel antigens that target more than one human patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec1b3a4c3341b4c86c16fc6f3719177
http://europepmc.org/articles/PMC5963808