Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Eman F, Abdelhaleem"'
Publikováno v:
Medicinal Chemistry. 18:903-914
Background: Breast cancer is currently the leading cause of worldwide cancer incidence exceeding lung cancer. In addition, breast cancer accounts for 1 in 4 cancer cases and 1 in 6 cancer deaths among women. Cytotoxic chemotherapy is still the main t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7fcd9452a7d4352b396e874a9d391e
https://doi.org/10.2174/1573406418666220309123648
https://doi.org/10.2174/1573406418666220309123648
Publikováno v:
Archiv der Pharmazie. 355:2200326
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) designed to be a selective cyclooxygenase-2 (COX-2) inhibitor. It was approved by the U.S. Food and Drug Administration for the treatment of inflammatory diseases such as osteoarthritis and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ec84d0c0d23159d36ec5d79b5cef43
https://doi.org/10.1002/ardp.202200326
https://doi.org/10.1002/ardp.202200326
Publikováno v:
Archiv der Pharmazie. 355:2200190
Series of new celecoxib analogs were synthesized to assess their anticancer activity against the MCF-7 cell line. Four compounds, 3a, 3c, 5b, and 5c, showed 1.4-9.2-fold more potent anticancer activity than celecoxib. The antiproliferative activity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292546de94f9c382969ef556fb016c28
https://doi.org/10.1002/ardp.202200190
https://doi.org/10.1002/ardp.202200190
Publikováno v:
European Journal of Medicinal Chemistry. 143:1807-1825
A series of novel tetrahydrobenzothieno[2,3-d]pyrimidine urea derivatives was synthesized according to fragment-based design strategy. They were evaluated for their anticancer activity against MCF-7 cell line. Three compounds 9c, 9d and 11b showed 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681d1c21ab2132638be46cc143809181
https://doi.org/10.1016/j.ejmech.2017.10.075
https://doi.org/10.1016/j.ejmech.2017.10.075