Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Eman A. Sobh"'
1
Akademický článek
Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno[2,3-d]pyrimidine derivatives as new EGFR inhibitors
Autor: Eman A. Sobh, Mohammed A. Dahab, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly, Ibrahim H. Eissa
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
A group of EGFR inhibitors derived from thieno[2,3-d]pyrimidine nucleus was designed, synthesised, and examined as anti-proliferative lead compounds. MCF-7 and A549 cell lines were inhibited by 5b, the most active member. It had inhibitory partialiti
Externí odkaz: https://doaj.org/article/318328a3c2e245ceb70a910f300bc6ba
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2
Akademický článek
Design, synthesis, docking, and anticancer evaluations of new thiazolo[3,2-a] pyrimidines as topoisomerase II inhibitors
Autor: Mona S. El-Zoghbi, Samiha A. El-Sebaey, Hanan A. AL-Ghulikah, Eman A. Sobh
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
New thiazolopyrimidine derivatives 2, 3a-d, 4a-c, 5, 6a-c, and 7a,b were synthesised. All prepared compounds were evaluated by MTT cytotoxicity assay against three human tumour cell lines. Compounds 3c, 3d, 4c, 6a, 6b, and 7b exhibited potent to stro
Externí odkaz: https://doaj.org/article/6844db220fd44e9b83ee585f52b77a0c
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3
Akademický článek
New benzothieno[2,3-c]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and in silico ADME profile studies
Autor: Nadia A. Khalil, Eman M. Ahmed, Ashraf F. Zaher, Eman A. Sobh, Samiha A. El-Sebaey, Mona S. El-Zoghbi
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1839-1859 (2021)
A series of [1]benzothieno[2,3-c]pyridines was synthesised. Most compounds were chosen by NCI-USA to evaluate their anticancer activity. Compounds 5a–c showed prominent growth inhibition against most cell lines. 5c was selected at five dose concent
Externí odkaz: https://doaj.org/article/7fd1385ad8224361afb139d530aa8210
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6
Computer aided drug discovery (CADD) of a thieno[2,3-d]pyrimidine derivative as a new EGFR inhibitor targeting the ribose pocket
Autor: Eman A. Sobh, Mohammed A. Dahab, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly, Ibrahim H. Eissa
Depending on the pharmacophoric characteristics of EGFR inhibitors, a new thieno[2,3-d]pyrimidine derivative has been developed. Firstly, the potential inhibitory effect of the designed compound against EGFR has been proven by docking experiments tha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9a2ec80378434b59612d7e7a696d1c
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7
Study of CD4, CD25 expression in transfusion dependent beta thalassemia patients
Autor: Aida S. Omar, Hoda A. Hassab, Abeer S. Elhadidi, Eman K. sobh
Repeated blood transfusions in patients with β-thalassemia cause multiple antigenic stimuli that might change the Treg cells percentage. Tregs have become popular subjects of immunological research in recent years, because of their critical role in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abaa9bf34784715fb3c0b51cb037c51d
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8
New benzothienopyrimidine derivatives as dual EGFR/ARO inhibitors: Design, synthesis, and their cytotoxic effect on MCF-7 breast cancer cell line
Autor: Eman A. Sobh, Nadia A. Khalil, Samar I. Faggal, Marwa S. A. Hassan
Publikováno v: Drug development researchREFERENCES. 83(5)
New cytotoxic agents based on benzothienopyrimidine scaffold were designed, synthesized, and evaluated against the MCF-7 breast cancer line in comparison to erlotinib and letrozole as reference drugs. Eight compounds demonstrated up to 20-fold higher
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f898e2e79e7c9c8f173d981bf8bce2
https://pubmed.ncbi.nlm.nih.gov/35286757
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9
New benzothieno[2,3-c]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and in silico ADME profile studies
Autor: Mona S. El-Zoghbi, Eman M. Ahmed, Nadia A. Khalil, Eman A. Sobh, Ashraf F. Zaher, Samiha A. El-Sebaey
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1839-1859 (2021)
A series of [1]benzothieno[2,3-c]pyridines was synthesised. Most compounds were chosen by NCI-USA to evaluate their anticancer activity. Compounds 5a–c showed prominent growth inhibition against most cell lines. 5c was selected at five dose concent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d55cc159fc1feed728dc142f5c9851
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10
Design, Synthesis, Antitumor activity, cell cycle analysis and ELISA assay for Cyclin Dependant Kinase-2 of a new (4-aryl-6-flouro-4H-benzo[4, 5] thieno[3, 2-b] pyran) derivatives
Autor: Ashraf Mouineer, Afaf A. El-Malah, Ashraf F. Zaher, Eman A. Sobh
Publikováno v: Mediterranean Journal of Chemistry, Vol 6, Iss 5, Pp 165-179 (2017)
A series of benzo[b]thiophene and their benzo[4,5]thieno[3,2-b]pyran derivatives (3a-f), (4a-f), (5a-f) and 6 were synthesized and characterized by spectroscopic and elemental analysis. All compounds were subjected to one dose anticancer screening in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bca8f6372c3d3a7bec17badcada14d4
https://doi.org/10.13171/mjc65/01709262240-zaher
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