Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Emad S Alnemri"'
Autor:
Dmitry Ratner, M Pontus A Orning, Megan K Proulx, Donghai Wang, Mikhail A Gavrilin, Mark D Wewers, Emad S Alnemri, Peter F Johnson, Bettina Lee, Joan Mecsas, Nobuhiko Kayagaki, Jon D Goguen, Egil Lien
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006035 (2016)
Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling. To counter this, innate immune responses can also sense some T3SS co
Externí odkaz:
https://doaj.org/article/7e19901ed97f4246a3cd738ecfdae743
Autor:
Lindsey Mayes-Hopfinger, Aura Enache, Jian Xie, Chou-Long Huang, Robert Köchl, Victor L. J. Tybulewicz, Teresa Fernandes-Alnemri, Emad S. Alnemri
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The serine/threonine kinase WNK1 is an inhibitor of chloride efflux. Here the authors show that this inhibition is a means of negatively regulating the activation of the NLRP3 inflammasome in macrophages, leading to reduced inflammatory responses.
Externí odkaz:
https://doaj.org/article/e7b7e958ca504bdc89a48c00f18c7b6c
Autor:
Corey Rogers, Dan A. Erkes, Alexandria Nardone, Andrew E. Aplin, Teresa Fernandes-Alnemri, Emad S. Alnemri
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Gasdermins mediate lytic cell death by forming pores in the plasma membrane. Here the authors show that gasdermins also permeabilize mitochondrial membrane, thereby facilitating intrinsic apoptosis pathway, downstream of apoptotic (Gasdermin E) and i
Externí odkaz:
https://doaj.org/article/d0672fa10e2747809092d92318838dba
Autor:
Pratyusha Mandal, Lynsey N. Nagrani, Liliana Hernandez, Anita Louise McCormick, Christopher P. Dillon, Heather S. Koehler, Linda Roback, Emad S. Alnemri, Douglas R. Green, Edward S. Mocarski
Publikováno v:
Viruses, Vol 13, Iss 9, p 1707 (2021)
Programmed cell death pathways eliminate infected cells and regulate infection-associated inflammation during pathogen invasion. Cytomegaloviruses encode several distinct suppressors that block intrinsic apoptosis, extrinsic apoptosis, and necroptosi
Externí odkaz:
https://doaj.org/article/f06cb379cd384a1fb21784dffe00b61d
Autor:
Corey Rogers, Teresa Fernandes-Alnemri, Lindsey Mayes, Diana Alnemri, Gino Cingolani, Emad S. Alnemri
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
DFNA5 is related to the caspase-dependent pyroptosis inducer gasdermin D. Here the authors find that DFNA5 is cleaved by caspase 3 and show this cleavage skews cells away from apoptosis into secondary necrosis, a form of cell death characterized by m
Externí odkaz:
https://doaj.org/article/ede72842f24b4015bf734b0a8c6dee76
Autor:
Megane Vernon, Nicole A. Wilski, Daniel Kotas, Weijia Cai, Danielle Pomante, Manoela Tiago, Emad S. Alnemri, Andrew E. Aplin
Publikováno v:
Mol Cancer Res
Lack of response and acquired resistance continue to be limitations of targeted and immune-based therapies. Pyroptosis is an inflammatory form of cell death characterized by the release of inflammatory damage-associated molecular patterns (DAMP) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc22ea530c53e4c1950691d4ccb1d5fd
https://doi.org/10.1158/1541-7786.mcr-22-0040
https://doi.org/10.1158/1541-7786.mcr-22-0040
Autor:
Corey Rogers, Emad S. Alnemri
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 5 (2019)
Gasdermin proteins have been extensively characterized for their ability to form necrotic pores in the plasma membrane, however, their interactions with other organelles have yet to be described. We recently demonstrated that some gasdermin proteins
Externí odkaz:
https://doaj.org/article/f19f8f321cc149a78da45b31c9bfec79
Autor:
Andrew E. Aplin, Emad S. Alnemri, Manoela Tiago, Danielle Pomante, Weijia Cai, Daniel Kotas, Nicole A. Wilski, Megane Vernon
Supplementary Figure from Raptinal Induces Gasdermin E–Dependent Pyroptosis in Naïve and Therapy-Resistant Melanoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5ebf1eb06a741eb37fa22813edc768
https://doi.org/10.1158/1541-7786.22528043
https://doi.org/10.1158/1541-7786.22528043
Autor:
Andrew E. Aplin, Emad S. Alnemri, Ulrich Rodeck, Edward J. Hartsough, Adam C. Berger, Conroy O. Field, Corey Rogers, Timothy J. Purwin, Ileine M. Sanchez, Weijia Cai, Dan A. Erkes
Combinations of BRAF inhibitors and MEK inhibitors (BRAFi + MEKi) are FDA-approved to treat BRAFV600E/K-mutant melanoma. Efficacy of BRAFi + MEKi associates with cancer cell death and alterations in the tumor immune microenvironment; however, the lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee70b84564b7891387261da0d8155668
https://doi.org/10.1158/2159-8290.c.6547885.v1
https://doi.org/10.1158/2159-8290.c.6547885.v1
Autor:
Andrew E. Aplin, Emad S. Alnemri, Ulrich Rodeck, Edward J. Hartsough, Adam C. Berger, Conroy O. Field, Corey Rogers, Timothy J. Purwin, Ileine M. Sanchez, Weijia Cai, Dan A. Erkes
Supplementary Figures and Legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f57c2bf609928e2fa8aaae5ec91e381
https://doi.org/10.1158/2159-8290.22535587
https://doi.org/10.1158/2159-8290.22535587