Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Emad Bahrami-Samani"'
Autor:
Lori L O'Brien, Qiuyu Guo, Emad Bahrami-Samani, Joo-Seop Park, Sean M Hasso, Young-Jin Lee, Alan Fang, Albert D Kim, Jinjin Guo, Trudy M Hong, Kevin A Peterson, Scott Lozanoff, Ramya Raviram, Bing Ren, Ben Fogelgren, Andrew D Smith, Anton Valouev, Andrew P McMahon
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007181 (2018)
Nephron progenitor number determines nephron endowment; a reduced nephron count is linked to the onset of kidney disease. Several transcriptional regulators including Six2, Wt1, Osr1, Sall1, Eya1, Pax2, and Hox11 paralogues are required for specifica
Externí odkaz:
https://doaj.org/article/435e97a2f642461e8fa6f0e4415c1cce
Autor:
Jenna M. Hendershot, Mohammad Abbasi, Laura Fortier, Maleah Benn, Camille Giacobone, Richard Del Mastro, Emad Bahrami-Samani, Amin R. Mazloom, Pankaj Oberoi
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 214
Preeclampsia is a serious condition responsible for much pregnancy-related morbidity and mortality. Diagnosis of preeclampsia is difficult due to the non-specific and subjective nature of symptoms of the disease. To reduce the subjective decision mak
Autor:
Zhijie Xie, Shayna Stein, Levon Demirdjian, Eddie Park, Ying Nian Wu, Emad Bahrami-Samani, Yang Pan, Yungang Xu, Yi Xing
Publikováno v:
American Journal of Human Genetics
Summary RNA sequencing (RNA-seq) is a powerful technology for studying human transcriptome variation. We introduce PAIRADISE (Paired Replicate Analysis of Allelic Differential Splicing Events), a method for detecting allele-specific alternative splic
Autor:
Emad Bahrami-Samani, Yi Xing
Publikováno v:
American Journal of Human Genetics
Gene expression is tightly regulated at the post-transcriptional level through splicing, transport, translation, and decay. RNA-binding proteins (RBPs) play key roles in post-transcriptional gene regulation, and genetic variants that alter RBP-RNA in
Autor:
Douglas L. Black, Chia-Ho Lin, Yi Ying, James A. Wohlschlegel, Andrey Damianov, Diana Tran, Kelsey C. Martin, Ji-Ann Lee, Emad Bahrami-Samani, Yi Xing, Ajay A. Vashisht
Publikováno v:
Cell, vol 165, iss 3
Rbfox proteins control alternative splicing and posttranscriptional regulation in mammalian brain and are implicated in neurological disease. These proteins recognize the RNA sequence (U)GCAUG, but their structures and diverse roles imply a variety o
Publikováno v:
Nucleic Acids Research
Nucleic acids research, vol 43, iss 22
Nucleic acids research, vol 43, iss 22
RNA-seq has become a popular technology for studying genetic variation of pre-mRNA alternative splicing. Commonly used RNA-seq aligners rely on the consensus splice site dinucleotide motifs to map reads across splice junctions. Consequently, genomic
Autor:
Andrew D. Smith, Mei Qiao, Myriam Gorospe, Helder I. Nakaya, Kotb Abdelmohsen, Patrícia R. Araújo, Jernej Ule, Raquel de Sousa Abreu, Caspar D. Kühnöl, Emad Bahrami-Samani, Philip J. Uren, Jennifer L. Martindale, Bruna R. Correa, Rebecca Pötschke, Dat T. Vo, Luiz O. F. Penalva, Suzanne C. Burns
Publikováno v:
Molecular and Cellular Biology. 35:2965-2978
The conserved RNA-binding protein Musashi1 (MSI1) has emerged as a key oncogenic factor in numerous solid tumors, including glioblastoma. However, its mechanism of action has not yet been established comprehensively. To identify its target genes comp
Autor:
Patrícia R. Araújo, Dat T. Vo, Andrew D. Smith, Emad Bahrami-Samani, Christine Vogel, Philip J. Uren, Luiz O. F. Penalva
Publikováno v:
Wiley Interdisciplinary Reviews: RNA. 6:291-310
Co- and post-transcriptional regulation of gene expression is complex and multifaceted, spanning the complete RNA lifecycle from genesis to decay. High-throughput profiling of the constituent events and processes is achieved through a range of techno
Publikováno v:
Nucleic Acids Research
High-throughput protein-RNA interaction data generated by CLIP-seq has provided an unprecedented depth of access to the activities of RNA-binding proteins (RBPs), the key players in co- and post-transcriptional regulation of gene expression. Motif di
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1648
RNA-seq is a powerful and popular technology for studying posttranscriptional regulation of gene expression, such as alternative splicing. The first step in analyzing RNA-seq data is to map the sequenced reads back to the genome. However, commonly us