Zobrazeno 1 - 10
of 628
pro vyhledávání: '"Emad A. Rakha"'
Autor:
Corinne L. Woodcock, Mansour Alsaleem, Michael S. Toss, Jennifer Lothion-Roy, Anna E. Harris, Jennie N. Jeyapalan, Nataliya Blatt, Albert A. Rizvanov, Regina R. Miftakhova, Yousif A. Kariri, Srinivasan Madhusudan, Andrew R. Green, Catrin S. Rutland, Rupert G. Fray, Emad A. Rakha, Nigel P. Mongan
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background N6-methyladenosine (m6A) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a m6A demethylase. Given the important role of m6A in biological m
Externí odkaz:
https://doaj.org/article/8fdaac6eb0dd41889920c42b595de135
Autor:
Tanjina Kader, Elena Provenzano, Madawa W. Jayawardana, Shona Hendry, Jia-Min Pang, Kenneth Elder, David J. Byrne, Lauren Tjoeka, Helen ML. Frazer, Eloise House, Sureshni I. Jayasinghe, Holly Keane, Anand Murugasu, Neeha Rajan, Islam M. Miligy, Michael Toss, Andrew R. Green, Emad A. Rakha, Stephen B. Fox, G. Bruce Mann, Ian G. Campbell, Kylie L. Gorringe
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-10 (2024)
Abstract Various histopathological, clinical and imaging parameters have been evaluated to identify a subset of women diagnosed with lesions with uncertain malignant potential (B3 or BIRADS 3/4A lesions) who could safely be observed rather than being
Externí odkaz:
https://doaj.org/article/b48a3f6e9ea54a189ccefd102db6473b
Autor:
Islam M. Miligy, Nahla Badr, Andrea Stevens, David Spooner, Rachna Awasthi, Yasmeen Mir, Anuj Khurana, Vijay Sharma, Usha Chandaran, Emad A. Rakha, Yasmine Maurice, Daniel Kearns, Rami Oweis, Amal Asar, Alastair Ironside, Abeer M. Shaaban
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7381 (2024)
Oestrogen receptor (ER)-positive breast cancer (BC) is generally well responsive to endocrine therapy. Neoadjuvant endocrine therapy (NAET) is increasingly being used for downstaging ER-positive tumours. This study aims to analyse the effect of NAET
Externí odkaz:
https://doaj.org/article/7839629df57844ff886af016daeab53d
Autor:
Brendah K. Masisi, Rokaya El Ansari, Lutfi Alfarsi, Ali Fakroun, Busra Erkan, Asmaa Ibrahim, Michael Toss, Ian O. Ellis, Emad A. Rakha, Andrew R. Green
Publikováno v:
Cancers, Vol 16, Iss 11, p 1949 (2024)
Background: Breast cancer (BC) remains heterogeneous in terms of prognosis and response to treatment. Metabolic reprogramming is a critical part of oncogenesis and a potential therapeutic target. Glutaminase (GLS), which generates glutamate from glut
Externí odkaz:
https://doaj.org/article/fbb287cfeedb4c9a84eedc4a1cb2661f
Autor:
Shorouk Makhlouf, Nehal M. Atallah, Susanna Polotto, Andrew H. S. Lee, Andrew R. Green, Emad A. Rakha
Publikováno v:
Cancers, Vol 16, Iss 10, p 1893 (2024)
Background: Invasive lobular carcinoma (ILC), the most common special type of breast cancer (BC), has unique clinical behaviour and is different from invasive ductal carcinoma of no special type (IDC-NST). However, ILC further comprises a diverse gro
Externí odkaz:
https://doaj.org/article/883a6be68ea74afeb0a1cbe5c5f02e0f
Autor:
Ayat Lashen, Shatha Alqahtani, Ahmed Shoqafi, Mashael Algethami, Jennie N. Jeyapalan, Nigel P. Mongan, Emad A. Rakha, Srinivasan Madhusudan
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 5053 (2024)
Cyclin-dependent kinase 2 (CDK2) is a key cell cycle regulator, with essential roles during G1/S transition. The clinicopathological significance of CDK2 in ductal carcinomas in situ (DCIS) and early-stage invasive breast cancers (BCs) remains largel
Externí odkaz:
https://doaj.org/article/a68b1f1a502d4ffd9994f0c77aec945b
Autor:
Ha-Linh Nguyen, Tatjana Geukens, Marion Maetens, Samuel Aparicio, Ayse Bassez, Ake Borg, Jane Brock, Annegien Broeks, Carlos Caldas, Fatima Cardoso, Maxim De Schepper, Mauro Delorenzi, Caroline A. Drukker, Annuska M. Glas, Andrew R. Green, Edoardo Isnaldi, Jórunn Eyfjörð, Hazem Khout, Stian Knappskog, Savitri Krishnamurthy, Sunil R. Lakhani, Anita Langerod, John W. M. Martens, Amy E. McCart Reed, Leigh Murphy, Stefan Naulaerts, Serena Nik-Zainal, Ines Nevelsteen, Patrick Neven, Martine Piccart, Coralie Poncet, Kevin Punie, Colin Purdie, Emad A. Rakha, Andrea Richardson, Emiel Rutgers, Anne Vincent-Salomon, Peter T. Simpson, Marjanka K. Schmidt, Christos Sotiriou, Paul N. Span, Kiat Tee Benita Tan, Alastair Thompson, Stefania Tommasi, Karen Van Baelen, Marc Van de Vijver, Steven Van Laere, Laura van’t Veer, Giuseppe Viale, Alain Viari, Hanne Vos, Anke T. Witteveen, Hans Wildiers, Giuseppe Floris, Abhishek D. Garg, Ann Smeets, Diether Lambrechts, Elia Biganzoli, François Richard, Christine Desmedt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Obesity is associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet its impact on BC biology remains understudied in humans. This study investigates how the biology of untreated primary BC di
Externí odkaz:
https://doaj.org/article/449fce543ad84736bc9d60953aa2df60
Autor:
Mashael Algethami, Michael S. Toss, Corinne L. Woodcock, Chandar Jaipal, Juliette Brownlie, Ahmed Shoqafi, Adel Alblihy, Katia A. Mesquita, Andrew R. Green, Nigel P. Mongan, Jennie N. Jeyapalan, Emad A. Rakha, Srinivasan Madhusudan
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Replication Protein A (RPA), a heterotrimeric complex consisting of RPA1, 2, and 3 subunits, is a single-stranded DNA (ssDNA)-binding protein that is critically involved in replication, checkpoint regulation and DNA repair. Here we have eval
Externí odkaz:
https://doaj.org/article/c5ad0bb1f1a94ed0a4920ebd299adf4e
Autor:
Ayat Lashen, Mashael Algethami, Shatha Alqahtani, Ahmed Shoqafi, Amera Sheha, Jennie N. Jeyapalan, Nigel P. Mongan, Emad A. Rakha, Srinivasan Madhusudan
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 4060 (2024)
Cyclin-dependent kinases (CDK2, CDK4, CDK6), cyclin D1, cyclin E1 and phosphorylated retinoblastoma (pRB1) are key regulators of the G1/S cell cycle checkpoint and may influence platinum response in ovarian cancers. CDK2/4/6 inhibitors are emerging t
Externí odkaz:
https://doaj.org/article/ca15e7d36f5e414faea844abed80e1fc
Autor:
Ronnachai Jaroensri, Ellery Wulczyn, Narayan Hegde, Trissia Brown, Isabelle Flament-Auvigne, Fraser Tan, Yuannan Cai, Kunal Nagpal, Emad A. Rakha, David J. Dabbs, Niels Olson, James H. Wren, Elaine E. Thompson, Erik Seetao, Carrie Robinson, Melissa Miao, Fabien Beckers, Greg S. Corrado, Lily H. Peng, Craig H. Mermel, Yun Liu, David F. Steiner, Po-Hsuan Cameron Chen
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Histologic grading of breast cancer involves review and scoring of three well-established morphologic features: mitotic count, nuclear pleomorphism, and tubule formation. Taken together, these features form the basis of the Nottingham Gradin
Externí odkaz:
https://doaj.org/article/e87e4501ec7945b0aef836b8987fc7e1