Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Emília Kletvíková"'
Autor:
Johan P. Turkenburg, Emília Kletvíková, Vaclav Veverka, Lenka Žáková, Christopher J. Watson, Andrzej M. Brzozowski, Martin Lepšík, Jiří Jiráček
Publikováno v:
Journal of Biological Chemistry. 288:10230-10240
Despite the recent first structural insight into the insulin-insulin receptor complex, the role of the C terminus of the B-chain of insulin in this assembly remains unresolved. Previous studies have suggested that this part of insulin must rearrange
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9daa3e20290a809a9f2bfcd0f658709b
https://doi.org/10.1074/jbc.m112.448050
https://doi.org/10.1074/jbc.m112.448050
Autor:
Christopher J. Watson, Rozálie Hexnerová, Václav Vaněk, Jana Straková, Daniel W. Wright, Jiří Jiráček, Emília Kletvíková, Michaela Collinsová, Lenka Žáková, Johan P. Turkenburg, Andrzej M. Brzozowski, Roberto J. Tarazona Aviñó, Jitka Viková, Vojtěch Kaplan, Vaclav Veverka, Miloš Buděšínský, Irena Selicharová
Publikováno v:
Scientific Reports
'Scientific Reports ', vol: 6, pages: 19431-1-19431-12 (2016)
'Scientific Reports ', vol: 6, pages: 19431-1-19431-12 (2016)
Insulin is a key hormone of human metabolism with major therapeutic importance for both types of diabetes. New insulin analogues with more physiological profiles and better glycemic control are needed, especially analogues that preferentially bind to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a0c0f441d12ee8023c2d2a64c86ae2
Autor:
Renato V. Iozzo, Jiri Jiracek, Andrea Morrione, Angela Palummo, Andrzej M. Brzozowski, Emília Kletvíková, Antonino Belfiore, Alaide Morcavallo, Marco Genua
Publikováno v:
Journal of Biological Chemistry. 287:11422-11436
The insulin receptor isoform A (IR-A) binds both insulin and insulin-like growth factor (IGF)-II, although the affinity for IGF-II is 3-10-fold lower than insulin depending on a cell and tissue context. Notably, in mouse embryonic fibroblasts lacking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b770ef2a7650b9f76cf41e0edf92a6f
https://doi.org/10.1074/jbc.m111.252478
https://doi.org/10.1074/jbc.m111.252478
Autor:
Geoffrey K.-W. Kong, Jiří Jiráček, Emília Kletvíková, Linda Whittaker, Shu Jin Chan, Michael A. Weiss, Andrzej M. Brzozowski, Christopher J. Watson, Brian J. Smith, John G. Menting, Donald F. Steiner, Jonathan Whittaker, Mai B. Margetts, Guy Dodson, Lenka Žáková, Colin W. Ward, Michael C. Lawrence
Insulin receptor signalling has a central role in mammalian biology, regulating cellular metabolism, growth, division, differentiation and survival1,2. Insulin resistance contributes to the pathogenesis of type 2 diabetes mellitus and the onset of Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c1c9e16f0f5f69287b9a27ad0e9fda
https://europepmc.org/articles/PMC3793637/
https://europepmc.org/articles/PMC3793637/
Autor:
Emília Kletvíková, Martin Lepšík, Michaela Collinsová, Christopher J. Watson, Johan P. Turkenburg, Andrzej M. Brzozowski, Jiří Jiráček, Lenka Žáková
Publikováno v:
ResearcherID
Acta Crystallographica Section D: Biological Crystallography
'Acta Crystallographica D ', vol: 70, pages: 2765-2774 (2014)
Acta Crystallographica Section D: Biological Crystallography
'Acta Crystallographica D ', vol: 70, pages: 2765-2774 (2014)
[AsnB26]- and [GlyB26]-insulin mutants attain a B26-turn like fold without assistance of chemical modifications. Their structures match the insulin receptor interface and expand the spectrum of insulin conformations.
The structural characterizat
The structural characterizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d18de9c9508ce9bf683646dc31867b
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000343060900025&KeyUID=CCC:000343060900025
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000343060900025&KeyUID=CCC:000343060900025