Structure of the Anti-C60 Fullerene Antibody Fab Fragment: Structural Determinants of Fullerene Binding

Autor: Em, Osipov, Od, Hendrickson, Tv, Tikhonova, Av, Zherdev, On, Solopova, Pg, Sveshnikov, Bb, Dzantiev, Vladimir Popov

Publikováno v: Acta Naturae
Europe PubMed Central

The structure of the anti-C60 fullerene antibody Fab fragment (FabC60) was solved by X-ray crystallography. The computer-aided docking of C60 into the antigen-binding pocket of FabC60 showed that binding of C60 to FabC60 is governed by the enthalpy a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::772ef5b34033f9a35334bb4db5a3d76a
https://pubmed.ncbi.nlm.nih.gov/31024749

The role of the local environment on the structural heterogeneity of carotenoid β-ionone rings.

Autor: Pishchalnikov RY; Prokhorov General Physics Institute of the Russian Academy of Sciences, Vavilov Str., 38, Moscow, Russia, 119991. rpishchal@kapella.gpi.ru., Yaroshevich IA; Department of Biophysics, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia, 119991., Zlenko DV; Department of Biophysics, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia, 119991.; A.N. Severtsov Institute of Ecology and Evolution (IEE), RAS, Moscow, Russia, 117071., Tsoraev GV; Department of Biophysics, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia, 119991., Osipov EM; Laboratory for Biocrystallography, KU Leuven, Herestraat 49, 3000, Leuven, Belgium., Lazarenko VA; National Research Center 'Kurchatov Institute', 1 Akademika Kurchatova Pl., Moscow, Russia, 123182., Parshina EY; Department of Biophysics, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia, 119991., Chesalin DD; Prokhorov General Physics Institute of the Russian Academy of Sciences, Vavilov Str., 38, Moscow, Russia, 119991., Sluchanko NN; A.N. Bach Institute of Biochemistry, Federal Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russia, 119071., Maksimov EG; Department of Biophysics, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia, 119991.

Publikováno v: Photosynthesis research [Photosynth Res] 2023 Apr; Vol. 156 (1), pp. 3-17. Date of Electronic Publication: 2022 Sep 05.

5-(Perylen-3-ylethynyl)uracil as an antiviral scaffold: Potent suppression of enveloped virus reproduction by 3-methyl derivatives in vitro.

Autor: Chistov AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Chumakov SP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Mikhnovets IE; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia., Nikitin TD; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia., Slesarchuk NA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Uvarova VI; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia., Rubekina AA; Department of Physics, Lomonosov Moscow State University, Moscow, 119991, Russia., Nikolaeva YV; Smorodintsev Research Institute of Influenza, St. Petersburg, 197376, Russia., Radchenko EV; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia., Khvatov EV; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia., Orlov AA; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia; Skolkovo Institute of Science and Technology, 143026, Moscow Region, Russia., Frolenko VS; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia; Institute of Translational Medicine and Biotechnology, Sechenov Moscow State Medical University, Moscow, 119991, Russia., Sukhorukov MV; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia., Kolpakova ES; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia., Shustova EY; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia., Galochkina AV; Smorodintsev Research Institute of Influenza, St. Petersburg, 197376, Russia., Streshnev PP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Osipov EM; Laboratory for Biocrystallography, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, 3000, Leuven, Belgium., Sapozhnikova KA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Moiseenko AV; Department of Biology, Moscow State University, Moscow, 119991, Russia., Brylev VA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia; Lumiprobe RUS Ltd., Moscow, 121351, Russia., Proskurin GV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Dokukin YS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Kutyakov SV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Aralov AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Korshun VA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia., Strelkov SV; Laboratory for Biocrystallography, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, 3000, Leuven, Belgium., Palyulin VA; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia., Ishmukhametov AA; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia; Institute of Translational Medicine and Biotechnology, Sechenov Moscow State Medical University, Moscow, 119991, Russia., Shirshin EA; Department of Physics, Lomonosov Moscow State University, Moscow, 119991, Russia., Osolodkin DI; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia; Institute of Translational Medicine and Biotechnology, Sechenov Moscow State Medical University, Moscow, 119991, Russia., Shtro AA; Smorodintsev Research Institute of Influenza, St. Petersburg, 197376, Russia., Kozlovskaya LI; FSASI 'Chumakov FSC R&D IBP RAS' (Institute of Poliomyelitis), Moscow, 108819, Russia; Institute of Translational Medicine and Biotechnology, Sechenov Moscow State Medical University, Moscow, 119991, Russia. Electronic address: lubov_i_k@mail.ru., Alferova VA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia. Electronic address: alferovava@gmail.com., Ustinov AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia; Lumiprobe RUS Ltd., Moscow, 121351, Russia. Electronic address: austinov@yandex.ru.

Publikováno v: Antiviral research [Antiviral Res] 2023 Jan; Vol. 209, pp. 105508. Date of Electronic Publication: 2022 Dec 26.

Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors.

Autor: Osipov EM; Biocrystallography, KU Leuven Herestraat 49 Leuven Belgium sergei.strelkov@kuleuven.be., Munawar AH; Biocrystallography, KU Leuven Herestraat 49 Leuven Belgium sergei.strelkov@kuleuven.be.; Orthogon Therapeutics LLC 45 Dan Road Suite 126 Canton MA 02021 USA.; Pledge Tx B.V. Gaston Geenslaan 1 Leuven Belgium., Beelen S; Biocrystallography, KU Leuven Herestraat 49 Leuven Belgium sergei.strelkov@kuleuven.be., Fearon D; Diamond Light Source Ltd., Harwell Science and Innovation Campus Didcot UK.; Research Complex at Harwell, Harwell Science and Innovation Campus Didcot OX11 0FA UK., Douangamath A; Diamond Light Source Ltd., Harwell Science and Innovation Campus Didcot UK.; Research Complex at Harwell, Harwell Science and Innovation Campus Didcot OX11 0FA UK., Wild C; Centre for Medicines Discovery, University of Oxford South Parks Road Headington OX3 7DQ UK.; Department of Statistics, University of Oxford 29 St Giles' Oxford OX1 3LB UK., Weeks SD; Biocrystallography, KU Leuven Herestraat 49 Leuven Belgium sergei.strelkov@kuleuven.be.; Pledge Tx B.V. Gaston Geenslaan 1 Leuven Belgium., Van Aerschot A; Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven Herestraat 49 Leuven Belgium., von Delft F; Diamond Light Source Ltd., Harwell Science and Innovation Campus Didcot UK.; Research Complex at Harwell, Harwell Science and Innovation Campus Didcot OX11 0FA UK.; Centre for Medicines Discovery, University of Oxford South Parks Road Headington OX3 7DQ UK.; Structural Genomics Consortium, University of Oxford Old Road Campus Roosevelt Drive Headington OX3 7DQ UK.; Department of Biochemistry, University of Johannesburg Auckland Park 2006 South Africa., Strelkov SV; Biocrystallography, KU Leuven Herestraat 49 Leuven Belgium sergei.strelkov@kuleuven.be.

Publikováno v: RSC chemical biology [RSC Chem Biol] 2022 Apr 29; Vol. 3 (8), pp. 1013-1027. Date of Electronic Publication: 2022 Apr 29 (Print Publication: 2022).

Crystal structure of Arabidopsis thaliana neutral invertase 2.

Autor: Tarkowski ŁP; Molecular Plant Biology Laboratory, Department of Biology, KU Leuven, Kasteelpark Arenberg 31, 3000 Leuven, Belgium., Tsirkone VG; Molecular Plant Biology Laboratory, Department of Biology, KU Leuven, Kasteelpark Arenberg 31, 3000 Leuven, Belgium., Osipov EM; Molecular Plant Biology Laboratory, Department of Biology, KU Leuven, Kasteelpark Arenberg 31, 3000 Leuven, Belgium., Beelen S; Laboratory for Biocrystallography, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Herestraat 49, O&N II, bus 822, 3000 Leuven, Belgium., Lammens W; Molecular Plant Biology Laboratory, Department of Biology, KU Leuven, Kasteelpark Arenberg 31, 3000 Leuven, Belgium., Vergauwen R; Molecular Plant Biology Laboratory, Department of Biology, KU Leuven, Kasteelpark Arenberg 31, 3000 Leuven, Belgium., Van den Ende W; Molecular Plant Biology Laboratory, Department of Biology, KU Leuven, Kasteelpark Arenberg 31, 3000 Leuven, Belgium., Strelkov SV; Laboratory for Biocrystallography, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Herestraat 49, O&N II, bus 822, 3000 Leuven, Belgium.

Publikováno v: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2020 Mar 01; Vol. 76 (Pt 3), pp. 152-157. Date of Electronic Publication: 2020 Mar 03.