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Cyclopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy

Autor: Verschuur, A. C., van Gennip, A. H., Leen, R., Muller, E. J., Elzinga, L., Voûte, P. A., van Kuilenburg, A. B.

Publikováno v: European journal of cancer (Oxford, England, 36(5), 627-635. Elsevier Limited

Cytidine triphosphate (CTP) synthetase is a key enzyme in the anabolic pathways of cytosine and uracil ribonucleotide metabolism. The enzyme catalyses the conversion of uridine triphosphate (UTP) into CTP, and has a high activity in various malignanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::651b2d30614639992b5408710099a33c
https://pure.amc.nl/en/publications/cyclopentenyl-cytosine-inhibits-cytidine-triphosphate-synthetase-in-paediatric-acute-nonlymphocytic-leukaemia-a-promising-target-for-chemotherapy(a5925ee6-30fa-4c1f-8312-f1a578b56821).html

A fast and novel assay of CTP synthetase. Evidence for hysteretic properties of the mammalian enzyme

Autor: van Kuilenburg, A. B., Elzinga, L., van den Berg, A. A., Slingerland, R. J., van Gennip, A. H.

Publikováno v: Anticancer research, 14(2A), 411-415. International Institute of Anticancer Research

A novel assay of CTP synthetase was developed which allows the processing of large numbers of samples. The amount of glutamate produced by CTP synthetase was determined with glutamate dehydrogenase and the NAD analogue acetyl-pyridine-adenine dinucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::6fdda890771b032c9d2c5928aedab127
https://pure.amc.nl/en/publications/a-fast-and-novel-assay-of-ctp-synthetase-evidence-for-hysteretic-properties-of-the-mammalian-enzyme(7d0b8a61-e0e1-46fc-8f52-cbd39972eefd).html

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Abstracts of poster presentations

Autor: Agostinho, A., Rosi, F., Tabucchi, A., Carlucci, F., Pizzichini, M., Arnér, Elias, Eriksson, Staffan, Barankiewicz, J., Trembacz, H., Zwierzchowski, L., Bergman, A., van Haperen, V., Veerman, G., Vermorken, J., Peters, G., Bory, C., Chantin, C., Rocca, J., Bzowska, A., Ananlev, A., Ramzaeva, N., Alksins, E., Maurins, J., Kulikowska, E., Shugar, D., Davies, P., Fairbanks, L., Simmonds, H., De Graaf, T., Van Dijk, W., de Jong, D., Huysmans, F., De Abreu, R., Monnens, L., Dijkman, H., van Liebergen, F., Assmann, K., Duley, J., Hanefeld, F., Fabianowska-Majewska, K., Duley, A., Greger, J., Wasiak, T., Gathof, B., Ried, T., Zwieauer, K., Gresser, U., Griesmacher, A., Weigel, G., Müller, M., Gross, M., Empl, W., Guisan, B., Roch-Ramel, F., Harley, E., Baumgarten, I., Kaletha, K., Nagel-Starczynowska, G., Karlsson, Anna, Lambooy, L., Boerbooms, A., De Abreu, R., van de Putte, L., Stolk, J., vd Pulte, L., Komissarov, A., Romanova, D., Debabov, V., Kozlov, A., Sokolov, V., Aksinenko, A., Fetisov, V., Komoriya, Keiji, Osada, Yoshio, Hasegawa, Masaichi, Kondo, Shiro, Couch, Ronald, Griffin, Travis, Lakaschus, G., Löffler, H., Löffler, M., Jiménez, M., Salinero, M., Guilarte, J., Matesanz, J., Medina, L., Galiana, J., Marlewski, M., Smolenski, R., Swierczynski, J., Rutkowski, B., Zydowo, M., Micheli, V., Pescaglini, M., Sestini, S., Jacomelli, G., Magagnoli, C., Pompucci, G., Hayek, G., Mimouni, M., Boptemps, F., Van den Berghe, G., Miranda, M., Mateos, F., Herrero, E., González, A., Puig, J., Miscetti, P., Minelli, A., Proietti, A., Moroni, M., Mezzasoma, I., Moro, J., Noam, I., Cameron, J., McBride, M., Mathew, C., Ogg, C., Puig, J., Miranda, M., Mateos, F., Luzi, L., Noordhuis, P., Kazemier, K., Kaspers, G., Overgaard-Hansen, K., Marcussen, M., Klenow, H., Pelatti, A., Quaratino, C., D'Amario, C., Tentarelli, R., Giacomello, A., Rocchigiani, M., Iacomelli, G., Pandolfi, M., Arezzini, L., Terzuoli, L., Pagani, R., Di Sciascio, N., Colosimo, A., Ranieri-Paggi, M., Ronca, F., Brown, P., Moir, A., Raggi, A., Schwendel, A., Grune, T., Siems, W., Holzhuetter, H., Sebesta, I., Krijt, J., Vondrak, K., Kmoch, S., Hrebicek, M., Senatore, G., Del Lucchese, G., Martini, C., Lucacchini, A., Siems, W., Mertsch, K., Blasig, I., Grune, T., Skladanowski, A., Hoffmann, C., Krass, J., Makarewicz, W., Jastorff, B., Slingerland, R., Bodlaender, J., Van Lenthe, H., Elzinga, L., Van Kuilenburg, A., Voûte, P., Van Gennip, A., Smid, K., van der Wilt, C., Aherne, G., Pinedo, H., Sorqi, M., Rucci, C., Zoppini, A., Staub, M., Sasvári-Székely, M., Spasokukockaja, T., Hrabák, A., Stolk, J., De Abreu, R., De Koning, D., Lambooy, L., Kerstens, P., Boerbooms, A., van de Putte, L., Szüts, P., Szirovicza, éva, åbrahám, C., Havass, Z., Jezewska, M., Van Acker, K., Eyskens, F., Verkerk, R., Scharpé, S., van Kuppevelt, T., Veerkamp, J., Sabina, R., Van Laar, J., Mayhew, E., Durrani, F., Peters, G., Rustum, Y., Wang, J., Leoncini, R., Vannoni, D., Marinello, E.

Publikováno v: Pharmacy World & Science; August 1993, Vol. 15 Issue: Supplement 4 pF15-F30, 16p