Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Elzbieta Zyner"'
Autor:
Dolf Evenberg, Karim Bahmed, Sunny A. Anuels, Beata Kosmider, Regina Osiecka, Justyn Ochocki, Elzbieta Zyner
Publikováno v:
Arzneimittelforschung. 60:149-156
cis-DDP (cis-diamminedichloroplatinu-m(II), CAS 15663-27-1) is widely used in chemotherapy of many types of cancer. However, besides effectiveness, it gives many side effects which limit its clinical application. Therefore, nowadays studies are focus
Publikováno v:
Journal of Inorganic Biochemistry. 105:518-524
In this study we examined their proapoptotic activity of cis -dichloridobis(3-imino-2-methoxyflavanone)ruthenium(II) 3H 2 O ( 1 ) and cis -dichloridobis(3-imino-2-ethoxyflavanone)ruthenium(II) 2H 2 O ( 2 ) towards human bladder carcinoma cell line EJ
Autor:
Bogumiła Żurowska, Małgorzata Łęczycka, Andrea Erxleben, Justyn Ochocki, Łukasz Glinka, Elzbieta Zyner
Publikováno v:
Inorganica Chimica Acta. 362:739-744
The synthesis and characterization of four new complexes with the bioactive ligand 3-aminoflavone (3-af) are reported. The complexes of general formula [M(3-af) 2 (H 2 O) 2 ](NO 3 ) 2 · n H 2 O], where M = Co(II), Ni(II), and Zn(II), and n = 0, 2, 0
Autor:
Elzbieta Zyner, Regina Osiecka, Izabela Zawlik, Justyn Ochocki, Jacek Bartkowiak, Pawel P. Liberski, Beata Kosmider
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 604:28-35
Currently cis-diamminedichloroplatinum(II) (cis-DDP) is one of the most commonly applied compounds in chemotherapy of many types of cancer. However, a drawback is that its effectiveness presents with many side effects. Therefore, human normal lymphoc
Autor:
Elzbieta Zyner, Regina Osiecka, Izabela Wojcik, Justyn Ochocki, Pawel P. Liberski, Jacek Bartkowiak, Beata Kosmider
Publikováno v:
Investigational New Drugs. 23:287-297
Lung cancer remains one of the most common causes of cancer-related death worldwide. Approximately 80% is histologically non-small cell lung carcinoma (NSCLC) and in about 70% of patients it is an unresectable type. Clinical studies indicated that ap
Publikováno v:
Drug and Chemical Toxicology. 28:231-244
cis-bis(3-aminoflavone)dichloroplatinum(II) [cis-Pt(II) complex of 3-aminoflavone] is an analog of cis-DDP characterized by low cytotoxicity and anticancer properties in vivo. In order to evaluate genotoxic properties of this chemical compound, the c
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 563:61-70
Non-small cell lung cancer (NSCLC) includes a group of tumors that respond poorly to drugs. cis-Diamminedichloroplatinum(II) (cis-DDP) toxicity still remains problematic, and not completely solved by the improvement of supportive care. Therefore, the
Autor:
Justyn Ochocki, Leszek Szmigiero, Regina Osiecka, Elzbieta Zyner, Ewa Ciesielska, Beata Kosmider
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 558:169-179
cis-Diamminedichloroplatinum(II) (cis-DDP) is one of the most widely administrated antitumor drugs. However, the use of cis-DDP is severely limited because of its toxic side effects. Therefore, efforts are concentrated on the development of improved
Autor:
Justyn Ochocki, Małgorzata Fabijańska, Elzbieta Zyner, Piotr Smolewski, Leszek Szmigiero, Kazimierz Studzian, Arno Pfitzner, Agnieszka J. Rybarczyk-Pirek, Barbara Cebula-Obrzut
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 44(3)
This paper describes the synthesis of trans-bis-(3-aminoflavone)dichloridoplatinum(II) (trans-Pt(3-af)2Cl2; TCAP) for use as a potential anticancer compound, and the evaluation of its structure by elemental and spectral analyses, and X-ray crystallog
Publikováno v:
ChemInform. 28
The synthesis of 3-substituted 2-phenyl-2,3-dihydro-4H-1,3,2-benzoxazaphosphorin-4-one 2-sulfide derivatives is described. The action of a series 2-oxide (1-6) and 2-sulfide (7-12) derivatives on the central nervous system has been evaluated. Compoun