Regulation of FOXP3 expression in myeloid cells in response to all-trans-retinoic acid, interleukin 2 and transforming growth factor β

Autor: Justyna Łopatecka, Aleksandra Ilnicka, Ewa Marcinkowska, Elzbieta Gocek

Publikováno v: Developmental & Comparative Immunology. 96:18-26

FoxP3 is a transcription factor essential for differentiation and function of T regulatory cells (Tregs). There are two major subsets of Tregs: natural Tregs (nTregs) generated in thymus and inducible Tregs (iTregs) produced in peripheral immune syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7707d0d01aad873e21db224a2495a13
https://doi.org/10.1016/j.dci.2019.02.019

List of Contributors

Autor: John S. Adams, Judith E. Adams, Jawaher A. Alsalem, Paul H. Anderson, Panagiota Andreopoulou, Edith Angellotti, Leggy A. Arnold, Gerald J. Atkins, Antonio Barbáchano, Shari S. Bassuk, Sarah Beaudin, Anna Y. Belorusova, Nancy A. Benkusky, Carlos Bernal-Mizrachi, Ishir Bhan, Harjit P. Bhattoa, Daniel D. Bikle, John P. Bilezikian, Neil C. Binkley, Heike A. Bischoff-Ferrari, Charles W. Bishop, Ida M. Boisen, Fabrizio Bonelli, Adele L. Boskey, Barbara J. Boucher, Roger Bouillon, Manuella Bouttier, Barbara D. Boyan, Danny Bruce, Laura Buburuzan, Andrew J. Burghardt, Thomas H.J. Burne, Mona S. Calvo, Carlos A. Camargo, Jorge B. Cannata-Andia, Margherita T. Cantorna, Carsten Carlberg, Geert Carmeliet, Thomas O. Carpenter, Graham D. Carter, Kevin D. Cashman, Lisa Ceglia, Sylvia Christakos, Kenneth B. Christopher, Rene F. Chun, Fredric L. Coe, Frederick Coffman, Juliet Compston, Cyrus Cooper, Elizabeth M. Curtis, Natalie E. Cusano, Michael Danilenko, G. David Roodman, Bess Dawson-Hughes, Pierre De Clercq, Hector F. DeLuca, Julie Demaret, Marie B. Demay, David W. Dempster, Elaine M. Dennison, Puneet Dhawan, Vassil Dimitrov, Katie M. Dixon, Maryam Doroudi, Shevaun M. Doyle, Adriana S. Dusso, Aleksey Dvorzhinskiy, Peter R. Ebeling, John A. Eisman, Gregory R. Emkey, Ervin H. Epstein Jr., Sol Epstein, Darryl Eyles, Murray J. Favus, David Feldman, Gemma Ferrer-Mayorga, David M. Findlay, James C. Fleet, Brian L. Foster, Renny T. Franceschi, David R. Fraser, Jessica M. Furst, Rachel I. Gafni, Edward Giovannucci, Christian M. Girgis, James L. Gleason, Francis H. Glorieux, Elzbieta Gocek, David Goltzman, José Manuel González-Sancho, Laura A. Graeff-Armas, William B. Grant, Natalie J. Groves, Conny Gysemans, Lasse Bøllehuus Hansen, Nicholas C. Harvey, Catherine M. Hawrylowicz, Colleen E. Hayes, Robert P. Heaney, Geoffrey N. Hendy, Pamela A. Hershberger, Martin Hewison, Michael F. Holick, Bruce W. Hollis, Philippe P. Hujoel, Elina Hyppönen, Karl L. Insogna, Nina G. Jablonski, Martin Blomberg Jensen, David A. Jolliffe, Glenville Jones, Kerry S. Jones, Harald Jüppner, Enikö Kallay, Andrew C. Karaplis, Martin Kaufmann, Mairead Kiely, Tiffany Y, Kim, Martin Konrad, Christopher S. Kovacs, Richard Kremer, Roland Krug, Rajiv Kumar, Noriyoshi Kurihara, Emma Laing, Joseph M. Lane, Dean P. Larner, María Jesús Larriba, Gilles Laverny, Nathalie Le Roy, Seong M. Lee, Michael A. Levine, Richard Lewis, Paul Lips, Thomas S. Lisse, Eva S. Liu, Philip T. Liu, Yan Li, Yan Chun Li, James G. MacKrell, Leila J. Mady, Sharmila Majumdar, Makoto Makishima, Peter J. Malloy, Elizabeth H. Mann, JoAnn E. Manson, Adrian R. Martineau, Rebecca S. Mason, Chantal Mathieu, Toshio Matsumoto, Donald G. Matthews, John J. McGrath, Daniel Metzger, Mark B. Meyer, Denshun Miao, Mathew T. Mizwicki, Rebecca J. Moon, Howard A. Morris, Li J. Mortensen, Alberto Muñoz, Yuko Nakamichi, Carmen J. Narvaez, Faye E. Nashold, Tally Naveh-Many, Carrie M. Nielson, Anthony W. Norman, Yves Nys, Melda Onal, Lubna Pal, Kristine Y. Patterson, Steven Pauwels, Pamela R. Pehrsson, Martin Petkovich, John M. Pettifor, Paul E. Pfeffer, Katherine M. Phillips, J. Wesley Pike, Stefan Pilz, Anastassios G. Pittas, Pawel Pludowski, David E. Prosser, Sri Ramulu N. Pullagura, L. Darryl Quarles, Rithwick Rajagopal, Katherine J. Ransohoff, Saaeha Rauz, Brian J. Rebolledo, Jörg Reichrath, Sandra Rieger, Amy E. Riek, Natacha Rochel, Jeffrey D. Roizen, Janet M. Roseland, Cliff Rosen, Mark S. Rybchyn, Hiroshi Saitoh, Reyhaneh Salehi-Tabar, Anne L. Schafer, Karl P. Schlingmann, Inez Schoenmakers, Zvi Schwartz, Kayla Scott, Christopher T. Sempos, Lusia Sepiashvili, Mukund Seshadri, Elizabeth Shane, Tatiana Shaurova, Irene Shui, Justin Silver, Ravinder J. Singh, Linda Skingle, René St-Arnaud, Jessica Starr, Keith R. Stayrook, Emily M. Stein, Ryan E. Stites, George P. Studzinski, Tatsuo Suda, Fumiaki Takahashi, Naoyuki Takahashi, Jean Y. Tang, Christine L. Taylor, Hugh S. Taylor, Peter J. Tebben, Thomas D. Thacher, Ravi Thadhani, Kebashni Thandrayen, Susan Thys-Jacobs, Dov Tiosano, Roberto Toni, Dwight A. Towler, Donald L. Trump, Nobuyuki Udagawa, André G. Uitterlinden, Aasis Unnanuntana, Jeroen van de Peppel, Bram C.J. van der Eerden, Marjolein van Driel, Johannes P.T.M. van Leeuwen, Natasja van Schoor, An-Sofie Vanherwegen, Aria Vazirnia, Lieve Verlinden, Annemieke Verstuyf, Reinhold Vieth, Carol L. Wagner, Graham R. Wallace, Connie Weaver, JoEllen Welsh, John H. White, Susan J. Whiting, Michael P. Whyte, John J. Wysolmerski, Sachiko Yamada, Olivia B. Yu, Kathryn Zavala, Christoph Zechner, Meltem Zeytinoglu, Hengguang Zhao

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ed16d9caf029689592e5e6285e6050c
https://doi.org/10.1016/b978-0-12-809965-0.01002-8

The Potential of Vitamin D-Regulated Intracellular Signaling Pathways as Targets for Myeloid Leukemia Therapy

Autor: George P. Studzinski, Elzbieta Gocek

Publikováno v: Journal of Clinical Medicine, Vol 4, Iss 4, Pp 504-534 (2015)
Journal of Clinical Medicine

The current standard regimens for the treatment of acute myeloid leukemia (AML) are curative in less than half of patients; therefore, there is a great need for innovative new approaches to this problem. One approach is to target new treatments to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d762378dcc36a810c1a5862a6260b58
http://www.mdpi.com/2077-0383/4/4/504

MicroRNA-32 Upregulation by 1,25-Dihydroxyvitamin D3 in Human Myeloid Leukemia Cells Leads to Bim Targeting and Inhibition of AraC-Induced Apoptosis

Autor: Chang Gong Liu, Xuening Wang, Elzbieta Gocek, George P. Studzinski, Xiuping Liu

Publikováno v: Cancer Research. 71:6230-6239

1,25-Dihydroxyvitamin D3 (1,25D) used to treat human acute myeloid leukemia (AML) cells induces features of normal monocytes, but the mechanisms underlying this response are not fully understood. We hypothesized that one or more microRNAs (miRNA) kno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d28dc0d7cbba7315157fb0f8213fe1
https://doi.org/10.1158/0008-5472.can-11-1717

Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and upregulates p27Kip1concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D3

Autor: Xuening Wang, Elzbieta Gocek, Jonathan S. Harrison, George P. Studzinski, Michael Danilenko, Victoria Novik

Publikováno v: Cell Cycle. 9:4542-4551

Acute myelogenous leukemia (AML) is a disease characterized by dysregulated cell proliferation associated with impaired cell differentiation, and current treatment regimens rarely save the patient. Thus, new mechanism-based approaches are needed to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af8a4f09b4e8d2c44e791d5b4a482da
https://doi.org/10.4161/cc.9.22.13790