Výsledky vyhledávání - "Elza T. Sakamoto-Hojo"

Akademický článek

Lymphocytes of Patients with Alzheimer’s Disease Display Different DNA Damage Repair Kinetics and Expression Profiles of DNA Repair and Stress Response Genes

Autor: Elza T. Sakamoto-Hojo, Julio C. Moriguti, Douglas V. N. P. Oliveira, Giovana S. Leandro, Romulo R. Lobo

Publikováno v: International Journal of Molecular Sciences, Vol 14, Iss 6, Pp 12380-12400 (2013)

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, characterized by loss of memory and cognitive capacity. Given the limitations to analyze brain cells, it is important to study whether peripheral lymphocytes can provide biologic

Externí odkaz: https://doaj.org/article/bb11cf26499b434593eb8e6a6ccc6cf2

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Akademický článek

Aire downregulation is associated with changes in the posttranscriptional control of peripheral tissue antigens in medullary thymic epithelial cells.

Autor: Ernna Hérida Oliveira, Claudia Macedo, Cristhianna Viesti Advincula Collares, Ana C. Freitas, Paula B. Donate, Elza T. Sakamoto-Hojo, Eduardo Antonio Donadi, Geraldo Aleixo Passos

Publikováno v: Frontiers in Immunology, Vol 7 (2016)

Autoimmune regulator (Aire) is a transcriptional regulator of peripheral tissue antigens (PTAs) and microRNAs (miRNAs) in medullary thymic epithelial cells (mTECs). In this study, we tested the hypothesis that Aire also played a role as an upstream p

Externí odkaz: https://doaj.org/article/9b4a41c8d3ef4d8e92661d8672629877

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Akademický článek

Promiscuous Gene Expression in the Thymus: The Root of Central Tolerance

Autor: Elza T. Sakamoto-Hojo, Eduardo A. Donadi, Ana Lucia Fachin, Paula Sandrin-Garcia, Cristina M. Junta, Danielle A. R. Magalhães, Eduardo L. V. Silveira, Geraldo A. S. Passos

Publikováno v: Clinical and Developmental Immunology, Vol 13, Iss 2-4, Pp 81-99 (2006)

Externí odkaz: https://doaj.org/article/2c7805c4405c4903af46a3bff5a2e288

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Akademický článek

Correction: T Cell Post-Transcriptional miRNA-mRNA Interaction Networks Identify Targets Associated with Susceptibility/Resistance to Collagen-induced Arthritis.

Autor: Paula B. Donate, Thais A. Fornari, Claudia Macedo, Thiago M. Cunha, Daniele C. B. Nascimento, Elza T. Sakamoto-Hojo, Eduardo A. Donadi, Fernando Q. Cunha, Geraldo A. Passos

Publikováno v: PLoS ONE, Vol 8, Iss 6 (2013)

Externí odkaz: https://doaj.org/article/e55dc6e6ef48404abe5481f5bb49bff1

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Akademický článek

Development of Type 1 Diabetes Mellitus in Nonobese Diabetic Mice Follows Changes in Thymocyte and Peripheral T Lymphocyte Transcriptional Activity

Autor: Thais A. Fornari, Paula B. Donate, Claudia Macedo, Elza T. Sakamoto-Hojo, Eduardo A. Donadi, Geraldo A. Passos

Publikováno v: Clinical and Developmental Immunology, Vol 2011 (2011)

As early as one month of age, nonobese diabetic (NOD) mice feature pancreatic infiltration of autoreactive T lymphocytes, which destruct insulin-producing beta cells, producing autoimmune diabetes mellitus (T1D) within eight months. Thus, we hypothes

Externí odkaz: https://doaj.org/article/3d70f68105dd49ce86781ea8b41241ec

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Transcript Expression Profiles and MicroRNA Regulation Indicate an Upregulation of Processes Linked to Oxidative Stress, DNA Repair, Cell Death, and Inflammation in Type 1 Diabetes Mellitus Patients

Autor: Paula Takahashi, Danilo J. Xavier, Jessica E. B. F. Lima, Adriane F. Evangelista, Cristhianna V. A. Collares, Maria C. Foss-Freitas, Diane M. Rassi, Eduardo A. Donadi, Geraldo A. Passos, Elza T. Sakamoto-Hojo

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Journal of Diabetes Research, Vol 2022 (2022)

Type 1 diabetes (T1D) arises from autoimmune-mediated destruction of insulin-producing β-cells leading to impaired insulin secretion and hyperglycemia. T1D is accompanied by DNA damage, oxidative stress, and inflammation, although there is still sca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f254ff870f365d381725fd865079ae
https://pubmed.ncbi.nlm.nih.gov/35155683

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Targeting NRF2, Regulator of Antioxidant System, to Sensitize Glioblastoma Neurosphere Cells to Radiation-Induced Oxidative Stress

Autor: Paulo R D V, Godoy, Ali, Pour Khavari, Marzia, Rizzo, Elza T, Sakamoto-Hojo, Siamak, Haghdoost

Publikováno v: Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, 2020, 2020, pp.1-17. ⟨10.1155/2020/2534643⟩

International audience; The presence of glioma stem cells (GSCs), which are enriched in neurospheres, may be connected to the radioresistance of glioblastoma (GBM) due to their enhanced antioxidant defense and elevated DNA repair capacity. The aim wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c04c92d8c77161c6a75afc47470c5a07
https://doaj.org/article/a2fe0609642a42af8df640e4cb3ea923

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Evaluation of a high dose to a finger from a 60Co accident

Autor: Marjori L. Camparato, Carmen S. Guzmán Calcina, Oswaldo Baffa, Angela Kinoshita, Cesar Picon, Elza T. Sakamoto-Hojo

Publikováno v: Health physics. 84(4)

Electron spin resonance and fluorescence in situ hybridization were used to evaluate the dose to the finger of a worker who accidentally touched a radiotherapy 60Co therapy source in November 1995. In September 1999, the middle finger was amputated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee31535efc04217f2456ab7891947fbd
https://pubmed.ncbi.nlm.nih.gov/12705446

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Modulatory effect of sodium butyrate on AluI-induced chromosomal aberrations in CHO cells

Autor: Adayapalam T. Natarajan, Elza T. Sakamoto Hojo, A.S. Balajee

Publikováno v: Mutation research. 309(2)

Exponentially growing CHO cells exposed to millimolar concentrations of sodium butyrate (SB) for 24 h were treated with Alu I using two methods of cell poration, i.e., electroporation and streptolysin O (SLO). Under both conditions, SB was found to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fbc475da8a83f29301973d5593e5e9
https://pubmed.ncbi.nlm.nih.gov/7520973

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