Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Elysse M. Knight"'
Autor:
Elysse M. Knight, Timothy M. Brown, Sarah Gümüsgöz, Jennifer C. M. Smith, Elizabeth J. Waters, Stuart M. Allan, Catherine B. Lawrence
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 1, Pp 160-170 (2013)
SUMMARY Alzheimer’s disease (AD) is characterised, not only by cognitive deficits and neuropathological changes, but also by several non-cognitive behavioural symptoms that can lead to a poorer quality of life. Circadian disturbances in core body t
Externí odkaz:
https://doaj.org/article/4eb220f44c31497998eac6e5e0dda030
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 5, Pp 649-659 (2012)
SUMMARY Obesity is associated with an increase in the prevalence and severity of infections. Genetic animal models of obesity (ob/ob and db/db mice) display altered centrally-mediated sickness behaviour in response to acute inflammatory stimuli such
Externí odkaz:
https://doaj.org/article/1c7d6fe4f81046bd81770dab32627628
Autor:
William L. Klein, Andrika Morant, Elysse M. Knight, Robert Boyd, B A Wustman, E R Sjoberg, D J Lockhart, K Yanagisawa, Sam Gandy, Soong Ho Kim, Jessica Kottwitz, A C Stevens, Michelle E. Ehrlich, Hadis Williams, John W. Steele
Publikováno v:
Molecular Psychiatry
Certain mutant Alzheimer's amyloid-β (Aβ) peptides (that is, Dutch mutant APP(E693Q)) form complexes with gangliosides (GAβ). These mutant Aβ peptides may also undergo accelerated aggregation and accumulation upon exposure to GM2 and GM3. We hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edeef5e91f2b15d57407711fab1b76e7
http://europepmc.org/articles/PMC5189927
http://europepmc.org/articles/PMC5189927
Autor:
Sarah Gümüsgöz, Isabel Pavão Martins, Catherine B. Lawrence, Stuart M. Allan, Elysse M. Knight
Publikováno v:
Neurobiology of Aging
Obesity and consumption of a high-fat diet are known to increase the risk of Alzheimer's disease (AD). Diets high in fat also increase disease neuropathology and/or cognitive deficits in AD mouse models. However, the effect of a high-fat diet on both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffa8d78d7dca5291d6112c35ced9cfe
http://europepmc.org/articles/PMC4024197
http://europepmc.org/articles/PMC4024197
Autor:
Minghao Zhong, Ina Caesar, Lijuan Liu, Victor Bustos, William J. Netzer, Dongming Cai, Li Zhu, Nikolaos K. Robakis, Hannah Rhee, Louise Lucast, Michelle E. Ehrlich, Laura A. Volpicelli-Daley, Elysse M. Knight, Jiaying Zhao, Sam Gandy
Publikováno v:
Journal of Biological Chemistry. 288:32050-32063
Recent studies link synaptojanin 1 (synj1), the main phosphoinositol (4,5)-biphosphate phosphatase (PI(4,5)P2-degrading enzyme) in the brain and synapses, to Alzheimer disease. Here we report a novel mechanism by which synj1 reversely regulates cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5c529cbe055083763351543093e3c8
https://doi.org/10.1074/jbc.m113.504365
https://doi.org/10.1074/jbc.m113.504365
Autor:
Ricardo Albay, Soong Ho Kim, Norman R. Relkin, Elysse M. Knight, Sam Gandy, Jessica Kottwitz, Paul Szabo, Cristina M. Alberini, Akinobu Suzuki, William L. Klein, Alex L. Lublin, John W. Steele, Asa Hatami, Michelle E. Ehrlich, Charles G. Glabe
Publikováno v:
Neurology® Neuroimmunology & Neuroinflammation
Background: Recent studies have implicated specific assembly subtypes of β-amyloid (Aβ) peptide, specifically soluble oligomers (soAβ) as disease-relevant structures that may underlie memory loss in Alzheimer disease. Removing existing soluble and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aaf9d9d5df2fc7a1006a61a0f83be75
http://europepmc.org/articles/PMC4864617
http://europepmc.org/articles/PMC4864617
Autor:
Christoph Buettner, Wilson Hsieh, William L. Klein, Henry H. Ruiz, Charles G. Glabe, Sam Gandy, Jessica C. Harte, Michelle E. Ehrlich, Alan D. Attie, Soong Ho Kim, Elysse M. Knight
Publikováno v:
Acta Neuropathologica Communications
Introduction Insulin resistance and type 2 diabetes mellitus (T2D) are associated with increased risk for cognitive impairment, Alzheimer’s disease (AD) and vascular dementia. SORCS1 encodes a protein-sorting molecule genetically linked to both T2D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4121fc1a396bcfac336dbd833bcc83f4
https://pubmed.ncbi.nlm.nih.gov/26916443
https://pubmed.ncbi.nlm.nih.gov/26916443
Autor:
Elysse M. Knight, S. Gandy
Publikováno v:
Journal of clinical immunology. 34
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and is the most common cause of dementia in the elderly. Interventions that remove existing fibrillar and oligomeric amyloid-β (Aβ) are believed to be essential for the success
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab8c23f0a35bf81eb9038c5872d8263
https://pubmed.ncbi.nlm.nih.gov/24781637
https://pubmed.ncbi.nlm.nih.gov/24781637
Publikováno v:
Alzheimer's & Dementia. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3328558e46d2d256fd759d84d85eedb8
https://doi.org/10.1016/j.jalz.2013.08.242
https://doi.org/10.1016/j.jalz.2013.08.242
Autor:
Soong Ho Kim, Elysse M Knight, Eric L Saunders, Azita K Cuevas, Marusia Popovech, Lung-Chi Chen, Sam Gandy
Publikováno v:
F1000Research, Vol 1 (2012)
Background: Over 20 genetic risk factors have been confirmed to associate with elevated risk for Alzheimer’s disease (AD), but the identification of environmental and/or acquired risk factors has been more elusive. At present, recognized acquired r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::9a12aeef0f3219dfd6a79e33600cd7ab
http://f1000research.com/articles/1-70/v1
http://f1000research.com/articles/1-70/v1