Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Elyssa B Margolis"'
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0232864 (2020)
Activation of the kappa opioid receptor (KOR) contributes to the aversive properties of stress, and modulates key neuronal circuits underlying many neurobehavioral disorders. KOR agonists directly inhibit ventral tegmental area (VTA) dopaminergic neu
Externí odkaz:
https://doaj.org/article/454e71a72da340cc94fb1fd759cebbb9
Autor:
Elyssa B Margolis, Howard L Fields
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159097 (2016)
Increased activity of lateral habenula (LHb) neurons is correlated with aversive states including pain, opioid abstinence, rodent models of depression, and failure to receive a predicted reward. Agonists at the mu opioid receptor (MOR) are among the
Externí odkaz:
https://doaj.org/article/51c70c5dab8f42b6ae9c73f1b05e6fd5
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42365 (2012)
The canonical two neuron model of opioid reward posits that mu opioid receptor (MOR) activation produces reward by disinhibiting midbrain ventral tegmental area (VTA) dopamine neurons through inhibition of local GABAergic interneurons. Although indir
Externí odkaz:
https://doaj.org/article/7af5fb7680734b54b84c90cbb5d59a6f
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15222 (2010)
Brain regions typically contain intermixed subpopulations of neurons with different connectivity and neurotransmitters. This complicates identification of neuronal phenotypes in electrophysiological experiments without using direct detection of uniqu
Externí odkaz:
https://doaj.org/article/9b8f11c9427f48aaaee2ed718ce78946
Autor:
Maggie W. Waung, Kayla A. Maanum, Thomas J. Cirino, Joseph R. Driscoll, Chris O’Brien, Svetlana Bryant, Kasra A. Mansourian, Marisela Morales, David J. Barker, Elyssa B. Margolis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Mu opioid receptor (MOR) agonists are potent analgesics, but also cause sedation, respiratory depression, and addiction risk. The epithalamic lateral habenula (LHb) signals aversive states including pain, and here we found that it is a potent site fo
Publikováno v:
Neuropharmacology. 225:109376
The opioid G-protein coupled receptors (GPCRs) strongly modulate many of the central nervous system structures that contribute to neurological and psychiatric disorders including pain, major depressive disorder, and substance use disorders. To better
Autor:
Bing Liu, Ian Chambers, Gabriel E Mateo-Semidey, Hui-Ling Wang, Jorge Miranda-Barrientos, Shiliang Zhang, Marisela Morales, Smriti Mongia, Elyssa B. Margolis
Publikováno v:
Eur J Neurosci
The ventral tegmental area (VTA) contains dopamine neurons intermixed with GABA-releasing (expressing vesicular GABA transporter, VGaT), glutamate-releasing (expressing vesicular glutamate transporter, VGluT2), and co-releasing (co-expressing VGaT an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f16aee199f29b55a119897c667dc10
https://europepmc.org/articles/PMC8380271/
https://europepmc.org/articles/PMC8380271/
Autor:
Kayla Maanum, Maggie W. Waung, Marisela Morales, Svetlana Bryant, Kasra A. Mansourian, Joseph R. Driscoll, Elyssa B. Margolis, Chris O'Brien, David J. Barker
Mu opioid receptor (MOR) agonists are potent analgesics, but also cause sedation, respiratory depression, and addiction risk. The epithalamic lateral habenula (LHb) signals aversive states including pain and we found it is a potent site for MOR-agoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd138c5672b85fad815a3b5573747d2
https://doi.org/10.21203/rs.3.rs-125555/v1
https://doi.org/10.21203/rs.3.rs-125555/v1
Autor:
Maggie W, Waung, Kayla A, Maanum, Thomas J, Cirino, Joseph R, Driscoll, Chris, O'Brien, Svetlana, Bryant, Kasra A, Mansourian, Marisela, Morales, David J, Barker, Elyssa B, Margolis
Publikováno v:
Nature communications. 13(1)
Mu opioid receptor (MOR) agonists are potent analgesics, but also cause sedation, respiratory depression, and addiction risk. The epithalamic lateral habenula (LHb) signals aversive states including pain, and here we found that it is a potent site fo
Autor:
Bing Liu, Gabriel E Mateo-Semidey, Hui-Ling Wang, Jorge Miranda-Barrientos, Ian Chambers, Shiliang Zhang, Smriti Mongia, Elyssa B. Margolis, Marisela Morales
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05fd94f8f4c556f95de531bcda3ff4d
https://doi.org/10.1111/ejn.15156/v2/response1
https://doi.org/10.1111/ejn.15156/v2/response1