Neuropathology of COVID-19 (neuro-COVID): clinicopathological update

Autor: Jerry J Lou, Mehrnaz Movassaghi, Dominique Gordy, Madeline G Olson, Ting Zhang, Maya S Khurana, Zesheng Chen, Mari Perez-Rosendahl, Samasuk Thammachantha, Elyse J Singer, Shino D Magaki, Harry V Vinters, William H Yong

Publikováno v: Free Neuropathology, Vol 2, Pp 2-2 (2021)

Coronavirus disease 2019 (COVID-19) is emerging as the greatest public health crisis in the early 21st century. Its causative agent, Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), is an enveloped single-stranded positive-sense ribonucl

Externí odkaz: https://doaj.org/article/03eb036b4d544a1a97e3f9dd105243ee

Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients.

Autor: Petronela Ancuta, Anupa Kamat, Kevin J Kunstman, Eun-Young Kim, Patrick Autissier, Alysse Wurcel, Tauheed Zaman, David Stone, Megan Mefford, Susan Morgello, Elyse J Singer, Steven M Wolinsky, Dana Gabuzda

Publikováno v: PLoS ONE, Vol 3, Iss 6, p e2516 (2008)

Elevated plasma lipopolysaccharide (LPS), an indicator of microbial translocation from the gut, is a likely cause of systemic immune activation in chronic HIV infection. LPS induces monocyte activation and trafficking into brain, which are key mechan

Externí odkaz: https://doaj.org/article/1304820fd0c84fc4a3cb886afcd0ff22

Neuropathologic Findings in Elderly HIV-Positive Individuals

Autor: Shino D Magaki, Harry V Vinters, Christopher K Williams, Sergey Mareninov, Negar Khanlou, Jonathan Said, Natasha Nemanim, Jessica Gonzalez, Jose G Morales, Elyse J Singer, William H Yong

Publikováno v: J Neuropathol Exp Neurol
Journal of neuropathology and experimental neurology, vol 81, iss 7

The elderly HIV-positive population is growing due to the widespread use of combination antiretroviral therapy (cART), but the effects of longstanding HIV infection on brain aging are unknown. A significant proportion of HIV-positive individuals deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13880d56206a8b49c11b6d0392886588
https://doi.org/10.1093/jnen/nlac040

Predictors of Transition to Frailty in Middle-Aged and Older People With HIV: A Prospective Cohort Study

Autor: Dana Gabuzda, Vikas Misra, Hajime Uno, Elyse J. Singer, Susan Morgello, David R. Lorenz, David J. Moore, Shibani S. Mukerji, Benjamin B. Gelman

Publikováno v: J Acquir Immune Defic Syndr
Journal of acquired immune deficiency syndromes (1999), vol 88, iss 5
J Acquir Immune Defic Syndr, vol 88, iss 5

BACKGROUND: People with HIV (PWH) have increased frailty risk at younger ages compared with the general population. Multimorbidity is associated with frailty, yet effects of specific comorbidities on transition to frailty in PWH are unknown. SETTING:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda378581c9d706a37454a4fbc4f5547
https://pubmed.ncbi.nlm.nih.gov/34757975

A candidate gene study of intermediate histopathological phenotypes in HIV-associated neurocognitive disorders

Autor: Andrew J. Levine, Janet S. Sinsheimer, Elyse J. Singer, Eliezer Masliah, David J. Moore, Virawudh Soontornniyomkij, Steve Horvath, Asha R. Kallianpur, Sarah S. Ji

Publikováno v: Journal of neurovirology, vol 26, iss 4

HIV-associated neurocognitive disorders (HAND) describe a spectrum of neuropsychological impairment caused by HIV-1 infection. While the sequence of cellular and physiological events that lead to HAND remains obscure, it likely involves chronic neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1658e8e80f985fc867e298f3587d7680
https://escholarship.org/uc/item/58m8w5dt