Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Elwy H. Abdelkader"'
Publikováno v:
Beni-Suef University Journal of Basic and Applied Sciences, Vol 8, Iss 1, Pp 1-6 (2019)
Abstract Background Sickle cell disease (SCD) is a chronic hemolytic disease caused by an altered hemoglobin molecule (HbS) and was first termed as a molecular disease. Glutamic acid in the normal hemoglobin molecule (HbA), was replaced by valine in
Externí odkaz:
https://doaj.org/article/0f13586bff5a42288e638aa7cbfec1e7
Autor:
Kasuni B. Ekanayake, Mithun C. Mahawaththa, Haocheng Qianzhu, Elwy H. Abdelkader, Josemon George, Sven Ullrich, Rhys B. Murphy, Sarah E. Fry, Jason Johansen-Leete, Richard J. Payne, Christoph Nitsche, Thomas Huber, Gottfried Otting
Publikováno v:
Journal of Medicinal Chemistry. 66:5289-5304
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00884791996e968a253d8d701d9c46dd
https://doi.org/10.1021/acs.jmedchem.3c00222
https://doi.org/10.1021/acs.jmedchem.3c00222
Publikováno v:
ACS Sensors. 7:44-49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c418b6c2439bf43fe292e06903145b9
https://doi.org/10.1021/acssensors.1c02467
https://doi.org/10.1021/acssensors.1c02467
Publikováno v:
Organic & Biomolecular Chemistry. 20:2424-2432
19F-NMR spectra of the protein GB1 produced by cell-free protein synthesis with fluorinated amino acids substituting their canonical parent amino acids show exceptionally large chemical shift dispersions, which indicate structural conservation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbaaa07374c73d299624f4771275710
https://doi.org/10.1039/d2ob00145d
https://doi.org/10.1039/d2ob00145d
Autor:
Henry W. Orton, Elwy H. Abdelkader, Rebecca L. Frkic, Edan I Habel, Colin J. Jackson, Haocheng Qianzhu, Yi Jiun Tan, Gottfried Otting, Thomas Huber
Publikováno v:
Journal of the American Chemical Society. 143:19587-19598
Fluorine atoms are known to display scalar 19F-19F couplings in nuclear magnetic resonance (NMR) spectra when they are sufficiently close in space for nonbonding orbitals to overlap. We show that fluorinated noncanonical amino acids positioned in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::537edd439a3a933be41288d175a872fe
https://doi.org/10.1021/jacs.1c10104
https://doi.org/10.1021/jacs.1c10104
Autor:
Gottfried Otting, Elwy H. Abdelkader, Thomas Huber, Yi Jiun Tan, Haocheng Qianzhu, Luke A. Adams
Publikováno v:
Journal of the American Chemical Society. 143:1133-1143
Trimethylsilyl (TMS) groups present outstanding NMR probes of biological macromolecules as they produce intense singlets in 1H NMR spectra near 0 ppm, where few other proton resonances occur. We report a system for genetic encoding of N6-(((trimethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f808972a8809c260d6f4d4511fd89589
https://doi.org/10.1021/jacs.0c11971
https://doi.org/10.1021/jacs.0c11971
Autor:
Elwy H. Abdelkader, Gottfried Otting
Publikováno v:
Journal of Biotechnology. 325:145-151
The human rhinovirus 14 3C protease (HRV3C protease), in fusion with glutathione S-transferase also referred to as PreScission™ protease, is a cysteine protease of particular interest for affinity tag removal from fusion proteins due to its stringe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68db2f33194d22a6b2aad5fd20151802
https://doi.org/10.1016/j.jbiotec.2020.11.005
https://doi.org/10.1016/j.jbiotec.2020.11.005
Ligating a protein at a specific site with a tag molecule containing a paramagnetic metal ion provides a versatile way of generating pseudocontact shifts (PCSs) in nuclear magnetic resonance (NMR) spectra. PCSs can be observed for nuclear spins far f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0114f0db5013b4a4aec7455f693af4be
https://mr.copernicus.org/preprints/mr-2022-3/
https://mr.copernicus.org/preprints/mr-2022-3/
Publikováno v:
ACS sensors. 7(1)
A mutant aminoacyl-tRNA synthetase identified by a library selection system affords site-specific incorporation of 7-fluoro-L-tryptophan in response to an amber stop codon. The enzyme allows the production of proteins with a single hydrogen atom repl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cadd1035f3a2a45d2d98335d8255f64b
https://pubmed.ncbi.nlm.nih.gov/35005899
https://pubmed.ncbi.nlm.nih.gov/35005899