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Akademický článek

CD1d expression in paneth cells and rat exocrine pancreas revealed by novel monoclonal antibodies which differentially affect NKT cell activation.

Autor: Elisa Monzon-Casanova, Birte Steiniger, Stefanie Schweigle, Holger Clemen, Daniela Zdzieblo, Lisa Starick, Ingrid Müller, Chyung-Ru Wang, Sara Rhost, Susanna Cardell, Elwira Pyz, Thomas Herrmann

Publikováno v: PLoS ONE, Vol 5, Iss 9 (2010)

CD1d is a nonpolymorphic MHC class I-like molecule which presents nonpeptide ligands, e.g. glycolipids, to NKT cells. These cells are known to have multiple effects on innate and adaptive immune responses and on the development of pathological condit

Externí odkaz: https://doaj.org/article/edfd5180012744dd853e8c5794e12b17

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Direct identification of rat iNKT cells reveals remarkable similarities to human iNKT cells and a profound deficiency in LEW rats

Autor: Thomas Herrmann, Elwira Pyz, Lisa Starick, Ingrid Müller, Daniel Paletta, Elisa Monzón-Casanova, Derek B. Sant'Angelo

Publikováno v: European Journal of Immunology. 43:404-415

iNKT cells are a particular lymphocyte population with potent immunomodulatory capa-city; by promoting or suppressing immune responses against infections, tumors, and autoimmunity, iNKT cells are a promising target for immunotherapy. The hallmark of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67952ad9924e5c2e068dede3d99af1eb
https://doi.org/10.1002/eji.201242565

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C9orf72 is differentially expressed in the central nervous system and myeloid cells and consistently reduced in C9orf72, MAPT and GRN mutation carriers

Autor: Cornelis Blauwendraat, Javier Simón-Sánchez, Melissa Castillo-Lizardo, Emily M. Lynes, Ashutosh Dhingra, Elwira Pyz, Sasja Heetveld, Markus A. Hobert, Peter Heutink, Patrizia Rizzu, Margherita Francescatto, Matthis Synofzik

Publikováno v: Acta Neuropathologica Communications
Acta Neuropathologica Communications 4(1), 37 (2016). doi:10.1186/s40478-016-0306-7

A non-coding hexanucleotide repeat expansion (HRE) in C9orf72 is a common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) acting through a loss of function mechanism due to haploinsufficiency of C9orf72 or a gain of fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a786b14b66b1a5fc0cdc9f87e7210da
https://doi.org/10.1186/s40478-016-0306-7

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Reduction of Minimal Residual Disease in Pediatric B-lineage Acute Lymphoblastic Leukemia by an Fc-optimized CD19 Antibody

Autor: Hans-Georg Rammensee, Martin Ebinger, Roland Meisel, Friedhelm R. Schuster, Peter Lang, Carl-Philipp Schwarze, Ludger Grosse-Hovest, Rupert Handgretinger, Steffen Aulwurm, Kai-Erik Witte, Heiko-Manuel Teltschik, Tobias Feuchtinger, Elwira Pyz, Ursula J.E. Seidel, Patrick Schlegel, Martin Hofmann, Gundram Jung

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy. 24(9)

Prognosis of primary refractory and relapsed pediatric B-lineage acute lymphoblastic leukemia (ALL) is very poor. Relapse rates significantly correlate with persistent minimal residual disease (MRD). In MRD, favorable effector-target ratios prevail a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dba0302a44d8eb2d76f163e4542b7f4
https://pubmed.ncbi.nlm.nih.gov/27380762

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Generation, selection and preclinical characterization of an Fc-optimized FLT3 antibody for the treatment of myeloid leukemia

Autor: Maximilian Bamberg, Nübling T, Elwira Pyz, Ludger Große-Hovest, Martin Hofmann, Hans-Georg Rammensee, Steffen Aulwurm, Sebastian P. Haen, Bühring Hj, Gundram Jung, Helmut R. Salih, Schwartz K, Karin Schilbach

Publikováno v: Leukemia. 26:1228-1237

The therapeutic efficacy of humanized or chimeric second-generation antitumor antibodies is clearly established, but often limited. In recent years, defined modifications of the glycosylation pattern or the amino-acid sequence of the human immunoglob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d446f18b6aecd3d4722be646520766b8
https://doi.org/10.1038/leu.2011.372

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Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand

Autor: Gordon D. Brown, Elwira Pyz, Andrew S J Marshall, Siamon Gordon, Philip R. Taylor, Cristal Huysamen

Publikováno v: European Journal of Immunology. 38:1157-1163

Inhibitory receptors are required for the control of cellular activation and they play essential roles in regulating homeostasis and immunity. We previously identified a human inhibitory C-type lectin-like receptor, MICL (CLEC12A), a heavily glycosyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f74c26c942c2aa4886189683ed10a85
https://doi.org/10.1002/eji.200738057

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Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation

Autor: Siamon Gordon, Kevin M. Dennehy, Simon Y. C. Wong, Andrew S J Marshall, Gordon D. Brown, Delyth M. Reid, Janet A. Willment, Elwira Pyz, Pietro Dri

Publikováno v: European Journal of Immunology. 36:2159-2169

C-type lectins are the most diverse and prevalent lectin family in immunity. Particular interest has recently been attracted by the C-type lectin-like receptors on NK cells, which appear to regulate the activation/inhibitory balance of these cells, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d9139469e608ed3c9a70cacb69495b
https://doi.org/10.1002/eji.200535628

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Abstract B144: Reduction of minimal residual disease in pediatric B-precursor acute lymphoblastic leukemia by an Fc-optimized CD19 antibody

Autor: Ludger Grosse-Hovest, Hans-Georg Rammensee, Kai-Erik Witte, Peter Lang, Elwira Pyz, Patrick Schlegel, Martin Hofmann, Roland Meisel, Rupert Handgretinger, Friedhelm R. Schuster, Steffen Aulwurm, Gundram Jung, Ursula Joerdis Eva Seidel

Publikováno v: Cancer Immunology Research. 4:B144-B144

B-precursor acute lymphoblastic leukemia (BCP-ALL) is the most common childhood cancer. Although this disease can be successfully treated in 80 % of patients by chemotherapy, prognosis for primary refractory or relapsed patients is very poor. Even af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95d376482b4a5765b1d1994515e4f8d1
https://doi.org/10.1158/2326-6074.cricimteatiaacr15-b144

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Screening for Ligands of C-Type Lectin-Like Receptors

Autor: Gordon D. Brown, Elwira Pyz

Publikováno v: Methods in Molecular Biology ISBN: 9781617791383

In order to execute their immune functions, leukocytes interact with a broad range of cell types through cell surface receptors, such as those of the immunoglobulin and C-type lectin families, or indirectly through soluble factors. The characterizati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::309899dceb6bb33914cd3d1e82d00656
https://doi.org/10.1007/978-1-61779-139-0_1

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