Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Elvira R M Bakker"'
Autor:
Rodanthi Lyraki, Anaëlle Grabek, Amélie Tison, Lahiru Chamara Weerasinghe Arachchige, Mirko Peitzsch, Nicole Bechmann, Sameh A. Youssef, Alain de Bruin, Elvira R. M. Bakker, Frank Claessens, Marie-Christine Chaboissier, Andreas Schedl
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/3cf6a8997a32457ab1865951264cbcb2
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
IRS proteins are scaffolds that can activate survival signalling pathways. In this study, the authors identified IRS4 as a potential oncogene in breast cancer that leads to the constitutive activation of PI3K/AKT signalling and thus confers resistanc
Externí odkaz:
https://doaj.org/article/7589cf0b1b644bf996fe00987062fff0
Autor:
Max A. K. Rätze, Thijs Koorman, Thijmen Sijnesael, Blessing Bassey-Archibong, Robert van de Ven, Lotte Enserink, Daan Visser, Sridevi Jaksani, Ignacio Viciano, Elvira R. M. Bakker, François Richard, Andrew Tutt, Lynda O’Leary, Amanda Fitzpatrick, Pere Roca-Cusachs, Paul J. van Diest, Christine Desmedt, Juliet M. Daniel, Clare M. Isacke, Patrick W. B. Derksen
Publikováno v:
Oncogene. 41:3507-3509
Autor:
Elvira R M Bakker, Eline J. ter Steege
Publikováno v:
Oncogene
R-spondin (RSPO) proteins constitute a family of four secreted glycoproteins (RSPO1–4) that have appeared as multipotent signaling ligands. The best-known molecular function of RSPOs lie within their capacity to agonize the Wnt/β-catenin signaling
Autor:
Max A. K. Rätze, Thijs Koorman, Thijmen Sijnesael, Blessing Bassey-Archibong, Robert van de Ven, Lotte Enserink, Daan Visser, Sridevi Jaksani, Ignacio Viciano, Elvira R. M. Bakker, François Richard, Andrew Tutt, Lynda O’Leary, Amanda Fitzpatrick, Pere Roca-Cusachs, Paul J. van Diest, Christine Desmedt, Juliet M. Daniel, Clare M. Isacke, Patrick W. B. Derksen
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
Invasive lobular breast carcinoma (ILC) is characterized by proliferative indolence and long-term latency relapses. This study aimed to identify how disseminating ILC cells control the balance between quiescence and cell cycle re-entry. In the absenc
Autor:
Hans-Joachim Mollenkopf, Bertram Wiedenmann, Sascha Sauer, Hilmar Berger, Thomas F. Meyer, Michael Sigal, Michael E. Rothenberg, Maria del Mar Reines, Cornelius Fischer, Marta Kapałczyńska, Elvira R. M. Bakker, Stefanie Müllerke
Publikováno v:
Nature Cell Biology. 21:812-823
Wnt signalling stimulated by binding of R-spondin (Rspo) to Lgr-family members is crucial for gastrointestinal stem cell renewal. Infection of the stomach with Helicobacter pylori stimulates increased secretion of Rspo by myofibroblasts, leading to a
Autor:
Maarten van den Berge, Tim Koopmans, Mark H. Menzen, Victor Guryev, Ron Smits, Gerard H. Koppelman, Reinoud Gosens, I. Sophie T. Bos, Laura Hesse, Kuldeep Kumawat, Elvira R M Bakker, Martijn C. Nawijn
Publikováno v:
Scientific Reports
Scientific Reports, 10(1):6754. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, 10(1):6754. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Asthma is a heterogeneous disease characterized by chronic inflammation and structural changes in the airways. The airway smooth muscle (ASM) is responsible for airway narrowing and an important source of inflammatory mediators. We and others have pr
Autor:
Blessing Bassey-Archibong, Stephen J. Pettitt, Christopher J. Lord, Juliet M. Daniel, Sridevi Jaksani, Francois Richard, Thijs Koorman, Max Ratze, Rebecca Steele, Robert A. H. van de Ven, Christine Desmedt, Lotte Enserink, Clare M. Isacke, Elvira R M Bakker, Andrew Tutt, Paul J. van Diest, Thijmen Sijnesael, Patrick W. B. Derksen, Daan Visser, Amanda Fitzpatrick
Publikováno v:
Cancer Research. 81:LB246-LB246
Invasive lobular breast carcinoma (ILC) is a low grade and mostly chemo-refractory luminal-type breast cancer that has been linked to sustained proliferative quiescence and long-term latency relapses (15-20 years). Loss of E-cadherin causes metastati
Autor:
Matthias Schewe, Elvira R. M. Bakker, Nikki C Timmer, Andrea Sacchetti, John Hilkens, Gerjon J. Ikink, Mandy Boer, Ji-Ying Song, Martijn A.J. Koppens
Publikováno v:
Gut, 66(6), 1095-1105. BMJ Publishing Group
Objective The gross majority of colorectal cancer cases results from aberrant Wnt/β-catenin signalling through adenomatous polyposis coli ( APC) or CTNNB1 mutations. However, a subset of human colon tumours harbour, mutually exclusive with APC and C
Autor:
Michael, Sigal, Maria Del Mar, Reinés, Stefanie, Müllerke, Cornelius, Fischer, Marta, Kapalczynska, Hilmar, Berger, Elvira R M, Bakker, Hans-Joachim, Mollenkopf, Michael E, Rothenberg, Bertram, Wiedenmann, Sascha, Sauer, Thomas F, Meyer
Publikováno v:
Nature cell biology. 21(7)
Wnt signalling stimulated by binding of R-spondin (Rspo) to Lgr-family members is crucial for gastrointestinal stem cell renewal. Infection of the stomach with Helicobacter pylori stimulates increased secretion of Rspo by myofibroblasts, leading to a