Výsledky vyhledávání - "Elvira Olaso"

Akademický článek

Inhibition of DDR1 reduces invasive features of human A375 melanoma, HT29 colon carcinoma and SK-HEP hepatoma cells

Autor: Irene Romayor, Iker Badiola, Elvira Olaso

Publikováno v: Cell Adhesion & Migration, Vol 14, Iss 1, Pp 69-81 (2020)

DDR1 is a receptor tyrosine kinases for collagen and an adverse prognostic factor in primary and metastatic tumors.Despite this, DDR1 signaling and its functional consequences in tumor development remain unclear. RT-PCR and Western blot show that A37

Externí odkaz: https://doaj.org/article/d752f28eba9b49a88be1c9eeb9a10019

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Akademický článek

Decreased expression of the β2 integrin on tumor cells is associated with a reduction in liver metastasis of colorectal cancer in mice

Autor: Aitor Benedicto, Joana Marquez, Alba Herrero, Elvira Olaso, Elzbieta Kolaczkowska, Beatriz Arteta

Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-17 (2017)

Abstract Background Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this integrin has also been

Externí odkaz: https://doaj.org/article/83bbbd7f0b5f4e92a6b5fc0ec8f3f37f

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A Synthetic Analog of Resveratrol Inhibits the Proangiogenic Response of Liver Sinusoidal Cells during Hepatic Metastasis

Autor: Elvira Olaso, Aitor Benedicto, Aritz Lopategi, Fernando P. Cossio, Beatriz Arteta

Publikováno v: Biomolecules & Therapeutics. 30:162-169

We utilized Fas21, a resveratrol analog, to modulate the function of hepatic stellate cells (HSCs) and liver sinusoidal endothelial cells (LSECs) during the angiogenic phase of murine liver metastasis by B16 melanoma and 51b colorectal carcinoma. Pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ec46bdf138db03b678d6c5d6988781
https://doi.org/10.4062/biomolther.2021.062

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Liver sinusoidal endothelial cell ICAM-1 mediated tumor/endothelial crosstalk drives the development of liver metastasis by initiating inflammatory and angiogenic responses

Autor: Irene Romayor, Alba Herrero, Bård Smedsrød, Beatriz Arteta, Aitor Benedicto, Joana Marquez, Elvira Olaso

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Addi. Archivo Digital para la Docencia y la Investigación
instname
Scientific Reports

The prometastatic stroma generated through tumor cells/host cells interaction is critical for metastatic growth. To elucidate the role of ICAM-1 on the crosstalk between tumor and primary liver sinusoidal endothelial cells (LSECs) and hepatic stellat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28484dd2aa8c777e87f81c665d89711
http://link.springer.com/article/10.1038/s41598-019-49473-7

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Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction

Autor: Beatriz Arteta, Elvira Olaso, Alba Herrero, Irene Romayor, Aitor Benedicto

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
instname
Biomolecules & Therapeutics
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco

Liver colonization is initiated through the interplay between tumor cells and adhesion molecules present in liver sinusoidal endothelial cells (LSECs). This crosstalk stimulates tumor COX-2 upregulation and PGE 2 secretion. To elucidate the role of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89053fcbbffdfb535db92710b5af8bf9
http://hdl.handle.net/10810/51845

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Innate Lymphoid Cells in the Malignant Melanoma Microenvironment

Autor: Aintzane Asumendi, Beatriz Arteta, Aintzane Apraiz, Elvira Olaso, Joana Marquez, Aitor Benedicto, Andrea Agüera-Lorente

Publikováno v: Cancers
Cancers, Vol 12, Iss 3177, p 3177 (2020)
Addi. Archivo Digital para la Docencia y la Investigación
instname
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco

Simple Summary Innate lymphoid cells (ILCs) are the innate counterparts of adaptive immune cells. Emerging data indicate that they are also key players in the progression of multiple tumors. In this review we briefly describe ILCs’ functions in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74792a7c8a1c4301240c74400823c0db
http://hdl.handle.net/10810/48712

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Silencing of Sinusoidal DDR1 Reduces Murine Liver Metastasis by Colon Carcinoma

Autor: Elvira Olaso, Aitor Benedicto, Joana Marquez, Alba Herrero, Beatriz Arteta, Iker Badiola, Irene Romayor

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
instname
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Scientific Reports

Liver metastasis depends on the collagenous microenvironment generated by hepatic sinusoidal cells (SCs). DDR1 is an atypical collagen receptor linked to tumor progression, but whether SCs express DDR1 and its implication in liver metastasis remain u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4733273a7ff24b0baaab919a98639a9
http://hdl.handle.net/10810/50809

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Ocoxin oral solution® as a complement to irinotecan chemotherapy in the metastatic progression of colorectal cancer to the liver

Autor: Iera Hernandez‑Unzueta, Joana Marquez, Cristina Viera, Eduardo Sanz, Aitor Benedicto, Beatriz Arteta, Elvira Olaso

Publikováno v: Oncology Letters

Colorectal cancer (CRC) is an aggressive disease in which patients usually die due to its metastatic progression to the liver. Up to date, irinotecan is one of the most used chemotherapeutic agents to treat CRC metastasis with demonstrated efficacy.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0cddca92f6325625edbc9bbbf8c9397
https://doi.org/10.3892/ol.2017.6016

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Ocoxin Oral Solution Exerts an Antitumoral Effect in Pancreatic Cancer and Reduces the Stromal-Mediated Chemoresistance

Autor: Eduardo Sanz, Aitor Benedicto, Elvira Olaso, Irene Romayor, Iera Hernandez-Unzueta, Joana Marquez, Beatriz Arteta, Alba Herrero

Publikováno v: Pancreas

Supplemental digital content is available in the text.
Objectives Pancreatic carcinoma is one of the most aggressive cancers overcoming chemoresistance. Thus, novel compounds to complement the current antitumor agents are in need. Ocoxin oral so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ffb983555048197cf3a07618a3cd624
https://pubmed.ncbi.nlm.nih.gov/30946238

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Ocoxin® oral solution slows down tumor growth in an experimental model of colorectal cancer metastasis to the liver in Balb/c mice

Autor: Jorge Mena, Iera Hernandez-Unzueta, Joana Marquez, Eduardo Sanz, Beatriz Arteta, Aitor Benedicto, Elvira Olaso

Publikováno v: Oncology Reports

Liver metastatic disease is the main cause of death in colorectal cancer (CRC) patients. During metastatic spread of the disease an imbalance in the oxidative stress and inflammation plays a crucial role in tumor progression. In order to improve the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b5c9bba878f4b4a8df86343bc5672e
https://doi.org/10.3892/or.2015.4486

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