PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study

Autor: Benoit Gamain, Eleine Konaté, Alexis Kuppers, Gwenaelle Roguet, Myriam Kanté, Elvira Lopez-Perez, Amadou T. Konaté, Odile Launay, Issiaka Soulama, Moise Kabore, Linda Belarbi, Nicola K. Viebig, Florence Allais, Mathilde Bahuaud, Sodiomon B. Sirima, Cécilia Campion, Désiré Kargougou, Nadine Benhamouda, Amidou Ouedraogo, Arnaud Chêne, Nicolas Havelange, Valérie Boilet, Caroline Roussillon, San Maurice Ouattara, Pierre Loulergue, Rodolphe Thiébaut, Laura Richert, Eric Tartour, Hélène Espérou, Amidou Diarra, Aissata Barry, Odile Leroy, Frédéric Batteux, Alphonse Ouedraogo, Noelie Bere Henry, Issa Nebie, Jean-Philippe Semblat, Sébastien Dechavanne

Publikováno v: The Lancet Infectious Diseases
The Lancet Infectious Diseases, New York, NY : Elsevier Science ; The Lancet Pub. Group, 2001-, 2020, 20 (5), pp.585-597. ⟨10.1016/S1473-3099(19)30739-X⟩
The Lancet Infectious Diseases, 2020, 20 (5), pp.585-597. ⟨10.1016/S1473-3099(19)30739-X⟩

PRIMVAC is a VAR2CSA-derived placental malaria vaccine candidate aiming to prevent serious clinical outcomes of Plasmodium falciparum infection during pregnancy. We assessed the safety and immunogenicity of PRIMVAC adjuvanted with Alhydrogel or gluco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aea50e3acd648b0c8aab4deeff22fe5
https://pubmed.ncbi.nlm.nih.gov/32032567

Constitutive and Protein Kinase C-Regulated Secretory Cleavage of Alzheimer's β-Amyloid Precursor Protein: Different Control of Early and Late Events by the Proteasome

Autor: Elvira Lopez-Perez, Frédéric Checler, Sherwin Wilk, Philippe Marambaud

Publikováno v: Europe PubMed Central

The physiological processing of the beta-amyloid precursor protein (betaAPP) by a protease called alpha-secretase gives rise to APP alpha, a C-terminally truncated fragment of betaAPP with known neurotrophic and cytoprotective properties. Several lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25bfd9f0538ab52e1e014bb8d8d70a80
https://doi.org/10.1046/j.1471-4159.1997.69062500.x

Constitutive α-secretase cleavage of the β-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10

Autor: Stuart J. Frank, Yue Zhang, Frédéric Checler, John W.M. Creemers, Elvira Lopez-Perez, Nabil G. Seidah

Publikováno v: Journal of Neurochemistry. 76:1532-1539

The β-amyloid precursor protein (βAPP) undergoes a physiological cleavage triggered by one or several proteolytic activities referred to as α-secretases, leading to the secretion of sAPPα. Several lines of evidence indicate that the α-secretase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bf84458087d2f40d091cbb8839e4b62
https://doi.org/10.1046/j.1471-4159.2001.00180.x

Proteasome Inhibitors Prevent the Degradation of Familial Alzheimer’s Disease-Linked Presenilin 1 and Potentiate Aβ42 Recovery from Human Cells

Autor: Philippe Marambaud, Elvira Lopez-Perez, Frédéric Checler, Karine Ancolio

Publikováno v: Molecular Medicine. 4:147-157

Several lines of evidence suggest that most of the early-onset forms of familial Alzheimer’s disease (FAD) are due to inherited mutations borne by a chromosome 14–encoded protein, presenilin 1 (PS1). This is likely related to an increased product

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c3d39de0e269ef9f432d44ca397733c
https://doi.org/10.1007/bf03401912

The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein

Autor: Yveline Frobert, Elvira Lopez-Perez, Bruno Vincent, Bart De Strooper, Dieter Hartmann, Jacques Grassi, Paul Saftig, Erwan Paitel, Frédéric Checler

Publikováno v: ResearcherID
Scopus-Elsevier

We showed previously that PrPc undergoes constitutive and phorbol ester-regulated cleavage inside the 106–126 toxic domain of the protein, leading to the production of a fragment referred to as N1. Here we show by a pharmacological approach thato-p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c70cb52fb85d5dd611958194afbb734
https://pubmed.ncbi.nlm.nih.gov/11477090