Výsledky vyhledávání - "Elvira I. Rubakova"

Akademický článek

Overexpression of Adenylyl Cyclase Encoded by the Mycobacterium tuberculosis Rv2212 Gene Confers Improved Fitness, Accelerated Recovery from Dormancy and Enhanced Virulence in Mice

Autor: Margarita O. Shleeva, Tatyana K. Kondratieva, Galina R. Demina, Elvira I. Rubakova, Anna V. Goncharenko, Alexander S. Apt, Arseny S. Kaprelyants

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)

Earlier we demonstrated that the adenylyl cyclase (AC) encoded by the MSMEG_4279 gene plays a key role in the resuscitation and growth of dormant Mycobacterium smegmatis and that overexpression of this gene leads to an increase in intracellular cAMP

Externí odkaz: https://doaj.org/article/4236cf70bb434a3485522be01f91958a

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Prolonged infection triggered by dormant Mycobacterium tuberculosis: Immune and inflammatory responses in lungs of genetically susceptible and resistant mice

Autor: Elvira I. Rubakova, Arseny S. Kaprelyants, Alexander Dyatlov, Marina A. Kapina, Irina Linge, Tatiana Kondratieva, Elena Kondratieva, M. O. Shleeva, Alexander S. Apt

Publikováno v: PLoS ONE, Vol 15, Iss 9, p e0239668 (2020)
PLoS ONE

We developed an approach for substantial attenuation of Mycobacterium tuberculosis by prolonged culturing under gradually acidifying conditions. Bacteria subjected to acidification lost the capacity to form colonies on solid media, but readily resusc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9fabfc483061e59e8d9fba1f6a99db
https://doaj.org/article/a4801d6e187c481aac302e80e986e003

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A new model for chronic and reactivation tuberculosis: Infection with genetically attenuated Mycobacterium tuberculosis in mice with polar susceptibility

Autor: Alexander S. Apt, Alexander Dyatlov, Marina A. Kapina, Tatiana Kondratieva, Elvira I. Rubakova, Boris Nikonenko, Konstantin B. Majorov, Irina Linge, Elena Kondratieva

Publikováno v: Tuberculosis (Edinburgh, Scotland). 113

TB infection in mice develops relatively rapidly which interferes with experimental dissection of immune responses and lung pathology features that differ between genetically susceptible and resistant hosts. Earlier we have shown that the M. tubercul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785ce8be90886d102fe22faa02b1ca5f
https://pubmed.ncbi.nlm.nih.gov/30514495

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B Cells Delay Neutrophil Migration toward the Site of Stimulus: Tardiness Critical for Effective Bacillus Calmette-Guérin Vaccination against Tuberculosis Infection in Mice

Autor: Vladimir Evstifeev, Konstantin B. Majorov, Elvira I. Rubakova, Alexander S. Apt, Irina Linge, Tatiana Kondratieva

Publikováno v: The Journal of Immunology. 184:1227-1234

Mutations in the btk gene encoding Bruton’s tyrosine kinase cause X-linked immune deficiency, with impaired B lymphocyte function as the major phenotype. Earlier, we demonstrated that CBA/N-xid mice, unlike the wild-type CBA mice, were not protecte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd8d1353fc6f03a4cad477a0bf1017f8
https://doi.org/10.4049/jimmunol.0902011

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Specificity and efficacy of dendritic cell-based vaccination against tuberculosis with complex mycobacterial antigens in a mouse model

Autor: Irina Baturina, Alexander Pichugin, Tatiana Kondratieva, Svetlana N. Petrovskaya, Alexander S. Apt, Valentine Khlebnikov, Elena Kondratieva, Elvira I. Rubakova, David N. McMurray

Publikováno v: Tuberculosis. 87:134-144

Summary Dendritic cells (DC) likely play important and unique roles in the generation of protective immunity to mycobacteria. In order to clarify their contributions, bone marrow-derived DC loaded with Mycobacterium tuberculosis sonicate antigens wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ea3b3f6a8f93876a6b8a1097b0ceb8
https://doi.org/10.1016/j.tube.2006.06.002

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Reactivation of dormant 'non-culturable' Mycobacterium tuberculosis developed in vitro after injection in mice: both the dormancy depth and host genetics influence the outcome

Autor: M. O. Shleeva, Arseny S. Kaprelyants, Alexander S. Apt, Elvira I. Rubakova, G. N. Vostroknutova, Tatiana Kondratieva

Publikováno v: Microbial pathogenesis. 78

Three stocks of Mycobacterium tuberculosis H37Rv were cultured in vitro under prolonged hypoxic or acidified conditions until partial or complete loss of the capacity to form colonies on agar medium was achieved. Such dormant “non-culturable” myc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282bfb5967e92ef77d31f003b93f174d
https://pubmed.ncbi.nlm.nih.gov/25434928

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Capacity of lung stroma to educate dendritic cells inhibiting mycobacteria-specific T-cell response depends upon genetic susceptibility to tuberculosis

Autor: Elvira I. Rubakova, Alexander S. Apt, Nadezhda Logunova, Konstantin B. Majorov, Marina A. Kapina

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 8, p e72773 (2013)

The balance between activation and inhibition of local immune responses in affected tissues during prolonged chronic infections is important for host protection. There is ample evidence that regulatory, tolerogenic dendritic cells (DC) are developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485877d95317f960455077321f1dc577
https://pubmed.ncbi.nlm.nih.gov/23977351

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Mycobacterium tuberculosis attenuated by multiple deletions of rpf genes effectively protects mice against TB infection

Autor: Bavesh D. Kana, Alexander S. Apt, Vasilii Potapov, Elvira I. Rubakova, Sergey Biketov, Tatiana Kondratieva, Arseny S. Kaprelyants

Publikováno v: Tuberculosis (Edinburgh, Scotland). 91(3)

In this study, we investigated the residual virulence of mutants of Mycobacterium tuberculosis that are defective in 4 of the 5 rpf-like genes, their capacity to persist in the murine host and the utility present in these mutants to serve as novel va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0949d150809ddd3801f1bd7a71693e3e
https://pubmed.ncbi.nlm.nih.gov/21419703

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I/St mice hypersusceptible to Mycobacterium tuberculosis are resistant to M. avium

Autor: Alexander S. Apt, Elena Kondratieva, Tatiana Kondratieva, M. M. Averbakh, Svetlana N. Petrovskaya, Alexander Pichugin, Vladimir Evstifeev, Elvira I. Rubakova

Publikováno v: Infection and immunity. 75(10)

We previously demonstrated that mice of the I/St strain are extremely susceptible toMycobacterium tuberculosis, as well as to the taxonomically distant intracellular bacteriaChlamydia pneumoniaeandSalmonella enterica. To broaden our knowledge about t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9bc6186587af774deb4b1ec2a2eff8
https://pubmed.ncbi.nlm.nih.gov/17664269

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Analysis of cellular phenotypes that mediate genetic resistance to tuberculosis using a radiation bone marrow chimera approach

Autor: Elvira I. Rubakova, Evgeny B. Eruslanov, Alexander S. Apt, Konstantin B. Majorov, Tatiana Kondratieva

Publikováno v: Infection and immunity. 73(9)

Adoptive transfer of bone marrow cells from tuberculosis-resistant (I/St × A/Sn)F1donor mice into lethally irradiated susceptible I/St recipients changed their phenotype following infection with virulentMycobacterium tuberculosis. Compared to I/St�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82300c1180914602c8d18c3362297c56
https://pubmed.ncbi.nlm.nih.gov/16113343

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