Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Elvira De Leonibus"'
Autor:
Nicola Forte, Charlène Roussel, Brenda Marfella, Anna Lauritano, Rosaria Villano, Elvira De Leonibus, Emanuela Salviati, Tina Khalilzadehsabet, Giada Giorgini, Cristoforo Silvestri, Fabiana Piscitelli, Maria Pina Mollica, Vincenzo Di Marzo, Luigia Cristino
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract N-oleoylglycine (OlGly), a lipid derived from the basic component of olive oil, oleic acid, and N-oleoylalanine (OlAla) are endocannabinoid-like mediators. We report that OlGly and OlAla, by activating the peroxisome proliferator-activated r
Externí odkaz:
https://doaj.org/article/f96ca932348846f7b67fb53bcddc64d4
Autor:
Attilio Iemolo, Maria De Risi, Nadia Giordano, Giulia Torromino, Cristina Somma, Diletta Cavezza, Martina Colucci, Maria Mancini, Antonio de Iure, Rocco Granata, Barbara Picconi, Paolo Calabresi, Elvira De Leonibus
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Cognitive deficits, including working memory, and visuospatial deficits are common and debilitating in Parkinson’s disease. α-synucleinopathy in the hippocampus and cortex is considered as the major risk factor. However, little is known a
Externí odkaz:
https://doaj.org/article/3a072074db974ec284798fdb73dbfbf3
Autor:
Maria Rosito, Caterina Sanchini, Giorgio Gosti, Manuela Moreno, Simone De Panfilis, Maria Giubettini, Doriana Debellis, Federico Catalano, Giovanna Peruzzi, Roberto Marotta, Alessia Indrieri, Elvira De Leonibus, Maria Egle De Stefano, Davide Ragozzino, Giancarlo Ruocco, Silvia Di Angelantonio, Francesca Bartolini
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112104- (2023)
Summary: Microglia reactivity entails a large-scale remodeling of cellular geometry, but the behavior of the microtubule cytoskeleton during these changes remains unexplored. Here we show that activated microglia provide an example of microtubule reo
Externí odkaz:
https://doaj.org/article/38d2e4baa9324fc1904b07fb8e77f459
Autor:
Flaminia Pellegrini, Vittorio Padovano, Silvia Biscarini, Tiziana Santini, Adriano Setti, Silvia Giulia Galfrè, Valentina Silenzi, Erika Vitiello, Davide Mariani, Carmine Nicoletti, Giulia Torromino, Elvira De Leonibus, Julie Martone, Irene Bozzoni
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105891- (2023)
Summary: Here, we describe a conserved motor neuron-specific long non-coding RNA, Lhx1os, whose knockout in mice produces motor impairment and postnatal reduction of mature motor neurons (MNs). The ER stress-response pathway result specifically alter
Externí odkaz:
https://doaj.org/article/b48c2dc723174fb2b0106698386bd867
Autor:
Sabrina Carrella, Martina Di Guida, Simona Brillante, Davide Piccolo, Ludovica Ciampi, Irene Guadagnino, Jorge Garcia Piqueras, Mariateresa Pizzo, Elena Marrocco, Marta Molinari, Georgios Petrogiannakis, Sara Barbato, Yulia Ezhova, Alberto Auricchio, Brunella Franco, Elvira De Leonibus, Enrico Maria Surace, Alessia Indrieri, Sandro Banfi
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 11, Pp n/a-n/a (2022)
Abstract Inherited retinal diseases (IRDs) are a group of diseases whose common landmark is progressive photoreceptor loss. The development of gene‐specific therapies for IRDs is hampered by their wide genetic heterogeneity. Mitochondrial dysfuncti
Externí odkaz:
https://doaj.org/article/5ffcd1e1e6b74894ad6d8849c7cb89e8
Autor:
Nicola Forte, Serena Boccella, Lea Tunisi, Alba Clara Fernández-Rilo, Roberta Imperatore, Fabio Arturo Iannotti, Maria De Risi, Monica Iannotta, Fabiana Piscitelli, Raffaele Capasso, Paolo De Girolamo, Elvira De Leonibus, Sabatino Maione, Vincenzo Di Marzo, Luigia Cristino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The authors show that adult hippocampal neurogenesis is altered in the dentate gyrus of obese mice with subsequent inhibition of long-term potentiation and impairment of pattern separation. Inhibition of orexin-A action at orexin-1 receptors rescued
Externí odkaz:
https://doaj.org/article/cc36a8296dcb45b6b3ee6a982be5d94e
Autor:
Anna Scotto Rosato, Einar K Krogsaeter, Dawid Jaślan, Carla Abrahamian, Sandro Montefusco, Chiara Soldati, Barbara Spix, Maria Teresa Pizzo, Giuseppina Grieco, Julia Böck, Amanda Wyatt, Daniela Wünkhaus, Marcel Passon, Marc Stieglitz, Marco Keller, Guido Hermey, Sandra Markmann, Doris Gruber‐Schoffnegger, Susan Cotman, Ludger Johannes, Dennis Crusius, Ulrich Boehm, Christian Wahl‐Schott, Martin Biel, Franz Bracher, Elvira De Leonibus, Elena Polishchuk, Diego L Medina, Dominik Paquet, Christian Grimm
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 9, Pp n/a-n/a (2022)
Abstract Lysosomes are cell organelles that degrade macromolecules to recycle their components. If lysosomal degradative function is impaired, e.g., due to mutations in lysosomal enzymes or membrane proteins, lysosomal storage diseases (LSDs) can dev
Externí odkaz:
https://doaj.org/article/81fb1739060044f693962704d333fab5
Autor:
Maria De Risi, Michele Tufano, Filomena Grazia Alvino, Maria Grazia Ferraro, Giulia Torromino, Ylenia Gigante, Jlenia Monfregola, Elena Marrocco, Salvatore Pulcrano, Lea Tunisi, Claudia Lubrano, Dulce Papy-Garcia, Yaakov Tuchman, Alberto Salleo, Francesca Santoro, Gian Carlo Bellenchi, Luigia Cristino, Andrea Ballabio, Alessandro Fraldi, Elvira De Leonibus
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Lysosomal storage disorders, characterized by altered metabolism of heparan sulfate, cause autistic symptoms followed by dementia in children. Here, the authors show that embryonic dopaminergic neurodevelopmental defects due to altered function of he
Externí odkaz:
https://doaj.org/article/5ebeb3f36eeb489b8e165e8571b181e3
Autor:
Nicolina Cristina Sorrentino, Vincenzo Cacace, Maria De Risi, Veronica Maffia, Sandra Strollo, Novella Tedesco, Edoardo Nusco, Noemi Romagnoli, Domenico Ventrella, Yan Huang, Nan Liu, Susan L. Kalled, Vivian W. Choi, Elvira De Leonibus, Alessandro Fraldi
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 333-342 (2019)
Mucopolysaccharidosis type IIIA (MPS-IIIA) is a lysosomal storage disorder (LSD) caused by inherited defect of sulfamidase, a lysosomal sulfatase. MPS-IIIA is one of the most common and severe forms of LSDs with CNS involvement. Presently there is no
Externí odkaz:
https://doaj.org/article/2d49ccd1afa048a9bc751084b264762d
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Parkinson’s disease (PD) is characterized by motor dysfunctions including bradykinesia, tremor at rest and motor instability. These symptoms are associated with the progressive degeneration of dopaminergic neurons originating in the substantia nigr
Externí odkaz:
https://doaj.org/article/f68cb673c9c24530b2c9eee615311506