Chromatin dynamics through mouse preimplantation development revealed by single molecule localisation microscopy

Autor: Marta Portela, Daniel Jimenez-Carretero, Veronica Labrador, Maria Jose Andreu, Elvira Arza, Valeria R. Caiolfa, Miguel Manzanares

Publikováno v: Biology Open, Vol 11, Iss 8 (2022)

Most studies addressing chromatin behaviour during preimplantation development are based on biochemical assays that lack spatial and cell-specific information, crucial during early development. Here, we describe the changes in chromatin taking place

Externí odkaz: https://doaj.org/article/d966c318a29e45bb9f2852aeb93f8382

Cell fusion reprogramming leads to a specific hepatic expression pattern during mouse bone marrow derived hepatocyte formation in vivo.

Autor: Oscar Quintana-Bustamante, Esther Grueso, Ramon Garcia-Escudero, Elvira Arza, Alberto Alvarez-Barrientos, Isabel Fabregat, Maria Garcia-Bravo, Nestor W Meza, Jose C Segovia

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33945 (2012)

The fusion of bone marrow (BM) hematopoietic cells with hepatocytes to generate BM derived hepatocytes (BMDH) is a natural process, which is enhanced in damaged tissues. However, the reprogramming needed to generate BMDH and the identity of the resul

Externí odkaz: https://doaj.org/article/7e5ee3b5815344a4ae5686ff3487d995

Regulation of endothelial dynamics by PGC-1α relies on ROS control of VEGF-A signaling

Autor: Yolanda Olmos, Nieves García-Quintans, Alfonso Luque, Cristina Sánchez-Ramos, María Monsalve, Ignacio Prieto, Elvira Arza

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Peroxisome proliferator activated receptor γ co-activator 1α (PGC-1α) is a regulator of mitochondrial metabolism and reactive oxygen species (ROS) that is known to play a relevant role in angiogenesis. [Aims]: This study aims to investigate the ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed189ce2ef8536c897648d04b3a23aec
https://doi.org/10.1016/j.freeradbiomed.2016.01.021

Number and brightness analysis reveals that NCAM and FGF2 elicit different assembly and dynamics of FGFR1 in live cells

Autor: Moreno, Zamai, Antonio, Trullo, Marco, Giordano, Valeria, Corti, Elvira, Arza Cuesta, Chiara, Francavilla, Ugo, Cavallaro, Valeria R, Caiolfa

Publikováno v: Journal of cell science. 132(1)

Both fibroblast growth factor-2 (FGF2) and neural cell adhesion molecule (NCAM) trigger FGF receptor 1 (FGFR1) signaling; however, they induce remarkably distinct receptor trafficking and cellular responses. The molecular basis of such a dichotomy an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee9dd7832c02f3f61ac755f42ad8d61d
https://pubmed.ncbi.nlm.nih.gov/30478195

Young and Especially Senescent Endothelial Microvesicles Produce NADPH: The Fuel for Their Antioxidant Machinery

Autor: Lilian Puebla, Manuel R. Ramírez, Guillermo Bodega, Miriam Morán, Matilde Alique, Luis Magro, Sergio Ciordia, María Carmen Mena, Lourdes Bohorquez, Elvira Arza

Publikováno v: Oxidative Medicine and Cellular Longevity, Vol 2018 (2018)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Oxidative Medicine and Cellular Longevity

In a previous study, we demonstrated that endothelial microvesicles (eMVs) have a well-developed enzymatic team involved in reactive oxygen species detoxification. In the present paper, we demonstrate that eMVs can synthesize the reducing power (NAD(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f098dff789aaf36da77e8df404abfc