Výsledky vyhledávání - "Elvia Padilla"

Discovery of GlyT2 Inhibitors Using Structure-Based Pharmacophore Screening and Selectivity Studies by FEP+ Calculations

Autor: Filip Fratev, Ashley Bryan Lopez, Suman Sirimulla, Elvia Padilla, Manuel Miranda-Arango

Publikováno v: ACS Med Chem Lett

[Image: see text] In recent years, mammalian Glycine transporter 2 (GlyT2) has emerged as a promising target for the development of compounds against chronic pain states. In our current work, we discovered a new set of promising hits that inhibit the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3664aa09a99af2877842e7d0e271ad78
https://pubmed.ncbi.nlm.nih.gov/31223446

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Discovery of New Classes of Glycine transporter 2 (GlyT2) Inhibitors and Study of GlyT2 Selectivity by Combination of Novel Structural Based Virtual Screening Approach and Free Energy Perturbation (FEP+) Calculations

Autor: Elvia Padilla, Manuel Miranda-Arango, Filip Fratev, Suman Sirimulla

In recent years, the mammalian GlyT2 transporter have emerged as a promising target for the development of anti-chronic pain agents. In our current work, we discovered a new set of promising hits that inhibit the glycine transport at nano and micromo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59af17ffbfded3478d5a58f87d3d4563
https://doi.org/10.1101/510487

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