Human mesenchymal stromal cells inhibit platelet activation and aggregation involving CD73-converted adenosine

Autor: Netsch, P., Elvers-Hornung, S., Uhlig, S., Klüter, H., Huck, V., Kirschhöfer, F., Weiß, G., Janetzko, K., Solz, H., Wuchter, P., Bugert, P., Bieback, K.

Publikováno v: Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-17 (2018)
Stem cell research & therapy, 9 (1)

Background Mesenchymal stromal cells (MSCs) are promising cell therapy candidates. Clinical application is considered safe. However, minor side effects have included thromboembolism and instant blood-mediated inflammatory reactions suggesting an effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b76df491a0fe4d723fc615a0beb09b
http://link.springer.com/article/10.1186/s13287-018-0936-8

Pooled human bone marrow-derived mesenchymal stromal cells with defined trophic factors cargo promote dermal wound healing in diabetic rats by improved vascularization and dynamic recruitment of M2-like macrophages.

Autor: Willer H; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Donor Service Baden-Württemberg - Hessen, Mannheim, Germany.; Institute for Anatomy, University of Veterinary Medicine Hannover, Hannover, Germany., Spohn G; Institute for Transfusion Medicine and Immunohaematology, German Red Cross Blood Service Baden-Württemberg-Hessen, Frankfurt am Main, Germany., Morgenroth K; Institute for Transfusion Medicine and Immunohaematology, German Red Cross Blood Service Baden-Württemberg-Hessen, Frankfurt am Main, Germany., Thielemann C; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Donor Service Baden-Württemberg - Hessen, Mannheim, Germany., Elvers-Hornung S; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Donor Service Baden-Württemberg - Hessen, Mannheim, Germany., Bugert P; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Donor Service Baden-Württemberg - Hessen, Mannheim, Germany., Delorme B; Macopharma, Mouvaux, France., Giesen M; Macopharma, Mouvaux, France., Schmitz-Rixen T; German Society of Surgery, Berlin, Germany., Seifried E; Institute for Transfusion Medicine and Immunohaematology, German Red Cross Blood Service Baden-Württemberg-Hessen, Frankfurt am Main, Germany., Pfarrer C; Institute for Anatomy, University of Veterinary Medicine Hannover, Hannover, Germany., Schäfer R; Institute for Transfusion Medicine and Immunohaematology, German Red Cross Blood Service Baden-Württemberg-Hessen, Frankfurt am Main, Germany.; Institute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Freiburg, Germany., Bieback K; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Donor Service Baden-Württemberg - Hessen, Mannheim, Germany.; Mannheim Institute for Innate Immunoscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; FlowCore, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Aug 19; Vol. 13, pp. 976511. Date of Electronic Publication: 2022 Aug 19 (Print Publication: 2022).

Repeated administration of human bone marrow derived MSC expanded in virally inactivated human platelet lysate improves wound healing in diabetic rats

Autor: Willer, H., Thielemann, C., Elvers-Hornung, S., Spohn, G., Delorme, Giesen, M., Schäfer, R., Bieback, K.

Publikováno v: In Cytotherapy May 2021 23(5) Supplement:S54-S54

Inter-Laboratory Comparison of Extracellular Vesicle Isolation Based on Ultracentrifugation.

Autor: Torres Crigna A; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Donor Service Baden-Württemberg-Hessen, Mannheim, Germany., Fricke F; Department of Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center, Heidelberg, Germany., Nitschke K; Department of Urology and Urosurgery, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Worst T; Department of Urology and Urosurgery, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Division Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany., Erb U; Department of Pediatrics, Pediatric Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Karremann M; Department of Pediatrics, Pediatric Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Buschmann D; Department of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany., Elvers-Hornung S; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Donor Service Baden-Württemberg-Hessen, Mannheim, Germany., Tucher C; Department of Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Schiller M; Department of Medicine V, Heidelberg University Hospital, Heidelberg, Germany.; Department of Internal Medicine, Kliniken Hochfranken, Naila, Germany., Hausser I; EM-Lab, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Gebert J; Department of Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center, Heidelberg, Germany., Bieback K; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Donor Service Baden-Württemberg-Hessen, Mannheim, Germany.

Publikováno v: Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie [Transfus Med Hemother] 2021 Feb; Vol. 48 (1), pp. 48-59. Date of Electronic Publication: 2020 Jul 08.

Pro-angiogenic Activity Discriminates Human Adipose-Derived Stromal Cells From Retinal Pericytes: Considerations for Cell-Based Therapy of Diabetic Retinopathy.

Autor: Kremer H; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Red Cross Blood Donation Service Baden-Württemberg - Hessen, Mannheim, Germany., Gebauer J; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Red Cross Blood Donation Service Baden-Württemberg - Hessen, Mannheim, Germany., Elvers-Hornung S; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Red Cross Blood Donation Service Baden-Württemberg - Hessen, Mannheim, Germany., Uhlig S; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Red Cross Blood Donation Service Baden-Württemberg - Hessen, Mannheim, Germany.; FlowCore Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Hammes HP; 5th Medical Department, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Beltramo E; Department of Medical Sciences, University of Turin, Turin, Italy., Steeb L; PeloBiotech GmbH, Martinsried, Germany., Harmsen MC; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Sticht C; Center for Medical Research, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Klueter H; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Red Cross Blood Donation Service Baden-Württemberg - Hessen, Mannheim, Germany.; Mannheim Institute for Innate Immunoscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Bieback K; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Red Cross Blood Donation Service Baden-Württemberg - Hessen, Mannheim, Germany.; FlowCore Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Mannheim Institute for Innate Immunoscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; HEiKA-Heidelberg Karlsruhe Strategic Partnership, Karlsruhe Institute of Technology (KIT), Heidelberg University, Heidelberg, Germany., Fiori A; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Red Cross Blood Donation Service Baden-Württemberg - Hessen, Mannheim, Germany.; HEiKA-Heidelberg Karlsruhe Strategic Partnership, Karlsruhe Institute of Technology (KIT), Heidelberg University, Heidelberg, Germany.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2020 Jun 09; Vol. 8, pp. 387. Date of Electronic Publication: 2020 Jun 09 (Print Publication: 2020).