Viral burden is associated with age, vaccination, and viral variant in a population-representative study of SARS-CoV-2 that accounts for time-since-infection-related sampling bias.

Autor: Fryer HR; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, United Kingdom., Golubchik T; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, United Kingdom.; Sydney Infectious Diseases Institute (Sydney ID), School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia., Hall M; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, United Kingdom., Fraser C; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, United Kingdom.; Pandemic Sciences Institute, University of Oxford, Old Road Campus, Oxford, United Kingdom., Hinch R; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, United Kingdom., Ferretti L; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, United Kingdom.; Pandemic Sciences Institute, University of Oxford, Old Road Campus, Oxford, United Kingdom., Thomson L; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, United Kingdom., Nurtay A; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, United Kingdom., Pellis L; Department of Mathematics, University of Manchester, Manchester, United Kingdom.; The Alan Turing Institute, London, United Kingdom., House T; Department of Mathematics, University of Manchester, Manchester, United Kingdom., MacIntyre-Cockett G; Wellcome Centre for Human Genetics, Oxford, United Kingdom., Trebes A; Wellcome Centre for Human Genetics, Oxford, United Kingdom., Buck D; Wellcome Centre for Human Genetics, Oxford, United Kingdom., Piazza P; Wellcome Centre for Human Genetics, Oxford, United Kingdom., Green A; Wellcome Centre for Human Genetics, Oxford, United Kingdom., Lonie LJ; Wellcome Centre for Human Genetics, Oxford, United Kingdom., Smith D; The Hub for Biotechnology in the Built Environment, Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom., Bashton M; The Hub for Biotechnology in the Built Environment, Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom., Crown M; The Hub for Biotechnology in the Built Environment, Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom., Nelson A; Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom., McCann CM; Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom., Adnan Tariq M; Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom., Elstob CJ; Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom., Nunes Dos Santos R; Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom., Richards Z; Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom., Xhang X; Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom., Hawley J; Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom., Lee MR; Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom., Carrillo-Barragan P; Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom., Chapman I; Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom., Harthern-Flint S; Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom., Bonsall D; Pandemic Sciences Institute, University of Oxford, Old Road Campus, Oxford, United Kingdom.; Wellcome Centre for Human Genetics, Oxford, United Kingdom., Lythgoe KA; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, United Kingdom.; Pandemic Sciences Institute, University of Oxford, Old Road Campus, Oxford, United Kingdom.; Department of Biology, University of Oxford, Oxford, United Kingdom.

Publikováno v: PLoS pathogens [PLoS Pathog] 2023 Aug 14; Vol. 19 (8), pp. e1011461. Date of Electronic Publication: 2023 Aug 14 (Print Publication: 2023).

Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition.

Autor: Middleton FK; Newcastle University, Northern Institute for Cancer Research, Newcastle upon Tyne, UK., Patterson MJ; Newcastle University, Northern Institute for Cancer Research, Newcastle upon Tyne, UK., Elstob CJ; Newcastle University, Northern Institute for Cancer Research, Newcastle upon Tyne, UK., Fordham S; Newcastle University, Northern Institute for Cancer Research, Newcastle upon Tyne, UK., Herriott A; Newcastle University, Northern Institute for Cancer Research, Newcastle upon Tyne, UK., Wade MA; Newcastle University, Northern Institute for Cancer Research, Newcastle upon Tyne, UK., McCormick A; Newcastle University, Northern Institute for Cancer Research, Newcastle upon Tyne, UK., Edmondson R; Newcastle University, Northern Institute for Cancer Research, Newcastle upon Tyne, UK., May FE; Newcastle University, Northern Institute for Cancer Research, Newcastle upon Tyne, UK., Allan JM; Newcastle University, Northern Institute for Cancer Research, Newcastle upon Tyne, UK., Pollard JR; Vertex Pharmaceuticals (Europe) Limited, Milton Park, Abingdon, Oxfordshire, UK., Curtin NJ; Newcastle University, Northern Institute for Cancer Research, Newcastle upon Tyne, UK.

Publikováno v: Oncotarget [Oncotarget] 2015 Oct 20; Vol. 6 (32), pp. 32396-409.